Annotations: 7BV7

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C	PF15300	INTS6/SAGE1/DDX26B/CT45 C-terminus (INT_SG_DDX_CT_C)	INTS6/SAGE1/DDX26B/CT45 C-terminus	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Integrator complex subunit 3	-	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to ionizing radiation response to radiation response to abiotic stimulus double-strand break repair DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process recombinational repair metabolic process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression macromolecule biosynthetic process snRNA metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process RNA processing regulation of cellular process regulation of cell cycle phase transition signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle mitotic G2/M transition checkpoint cell communication regulation of mitotic cell cycle negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition transcription elongation by RNA polymerase II regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity integrator complex cytoplasm site of double-strand break intracellular non-membrane-bounded organelle membrane-bounded organelle intracellular organelle protein-containing complex SOSS complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity integrator complex cytoplasm site of double-strand break intracellular non-membrane-bounded organelle site of DNA damage chromosome non-membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C	Integrator complex subunit 6	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process snRNA metabolic process organic substance metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process snRNA metabolic process organic substance metabolic process biosynthetic process snRNA processing organic substance biosynthetic process nucleic acid catabolic process metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR045334	Integrator complex subunit 3	Family
A, B	IPR019333	Integrator complex subunit 3, N-terminal	Domain
C	IPR002035	von Willebrand factor, type A	Domain
C	IPR029307	INTS6/SAGE1/DDX26B/CT45, C-terminal	Domain
C	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C	Pharos: Q9UL03	lung cancer ovarian cancer tuberculosis malignant mesothelioma Pick disease osteosarcoma sarcoidosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.