Annotations: 7BU5

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e7bu5B1	A: alpha arrays	X: LEM/SAP HeH motif-like	H: LEM/SAP HeH motif	T: LEM/SAP HeH motif	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e7bu5A1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: F_UNCLASSIFIED	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
B	Structure-specific endonuclease subunit SLX4	DNA binding binding organic cyclic compound binding nucleic acid binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity cation binding ion binding metal ion binding small molecule binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction homologous recombination reproductive process resolution of meiotic recombination intermediates meiotic cell cycle process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process sexual reproduction homologous recombination reproductive process resolution of meiotic recombination intermediates meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle DNA recombination organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process cellular process formation of extrachromosomal circular DNA telomere organization chromosome organization telomere maintenance cellular component biogenesis cellular component assembly telomere maintenance via telomere trimming t-circle formation telomeric loop disassembly telomeric D-loop disassembly positive regulation of organelle organization regulation of telomere maintenance regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization regulation of t-circle formation positive regulation of biological process regulation of primary metabolic process positive regulation of metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of biological process positive regulation of telomere maintenance positive regulation of nucleobase-containing compound metabolic process positive regulation of cellular component biogenesis biological regulation regulation of chromosome organization regulation of macromolecule metabolic process regulation of cellular component biogenesis regulation of organelle organization positive regulation of chromosome organization positive regulation of DNA metabolic process positive regulation of t-circle formation regulation of metabolic process regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair negative regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening negative regulation of biological process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of cellular component organization negative regulation of metabolic process regulation of telomere maintenance via telomere lengthening negative regulation of organelle organization negative regulation of DNA metabolic process nucleotide-excision repair DNA double-strand break processing double-strand break repair via single-strand annealing DNA double-strand break processing involved in repair via single-strand annealing response to endogenous stimulus response to intra-S DNA damage checkpoint signaling response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to DNA integrity checkpoint signaling response to DNA damage checkpoint signaling response to cell cycle checkpoint signaling	cell junction cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen cell junction cellular anatomical entity membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle Slx1-Slx4 complex nuclear lumen non-membrane-bounded organelle cytoplasm cytosol nucleoplasm protein-DNA complex chromatin chromosome, telomeric region chromosomal region
A	MUS81 endonuclease homolog (Yeast), isoform CRA_b	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity catalytic activity, acting on a nucleic acid hydrolase activity 3'-flap endonuclease activity DNA nuclease activity DNA endonuclease activity DNA endonuclease activity, producing 3'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds flap endonuclease activity catalytic activity DNA binding endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters endonuclease activity catalytic activity, acting on a nucleic acid hydrolase activity 3'-flap endonuclease activity DNA nuclease activity DNA endonuclease activity DNA endonuclease activity, producing 3'-phosphomonoesters catalytic activity, acting on DNA nuclease activity hydrolase activity, acting on ester bonds flap endonuclease activity catalytic activity DNA binding binding organic cyclic compound binding nucleic acid binding crossover junction DNA endonuclease activity cation binding ion binding metal ion binding small molecule binding	catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process catabolic process primary metabolic process DNA metabolic process macromolecule catabolic process organic cyclic compound catabolic process nucleic acid metabolic process nucleobase-containing compound catabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process DNA catabolic process nucleic acid catabolic process metabolic process macromolecule metabolic process organic substance catabolic process DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity DNA replication replication fork processing cell population proliferation cellular process osteoblast proliferation sexual reproduction homologous recombination reproductive process resolution of meiotic recombination intermediates meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle DNA recombination organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process cellular response to stimulus double-strand break repair response to stimulus double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA damage checkpoint signaling regulation of cellular process regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction mitotic intra-S DNA damage checkpoint signaling regulation of cell cycle regulation of biological process regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling mitotic cell cycle process signal transduction in response to DNA damage response to endogenous stimulus response to intra-S DNA damage checkpoint signaling response to biotic stimulus cellular response to biotic stimulus cellular response to endogenous stimulus response to DNA integrity checkpoint signaling response to DNA damage checkpoint signaling response to cell cycle checkpoint signaling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex catalytic complex endodeoxyribonuclease complex Holliday junction resolvase complex intracellular protein-containing complex endonuclease complex nucleoplasm replication fork chromosome nuclear replication fork nuclear chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B	IPR000210	BTB/POZ domain	Domain
B	IPR018574	Structure-specific endonuclease subunit Slx4	Family
B	IPR006642	Rad18, zinc finger UBZ4-type	Domain
B	IPR011333	SKP1/BTB/POZ domain superfamily	Homologous Superfamily
A	IPR011335	Restriction endonuclease type II-like	Homologous Superfamily
A	IPR047417	MUS81, winged helix domain	Domain
A	IPR027421	DNA polymerase lambda lyase domain superfamily	Homologous Superfamily
A	IPR006166	ERCC4 domain	Domain
A	IPR047416	MUS81, XPF-like nuclease domain	Domain
A	IPR042530	EME1/EME2, C-terminal domain	Homologous Superfamily
A	IPR033309	Crossover junction endonuclease Mus81	Family
A	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B	Pharos: Q8IY92	Fanconi anemia Fanconi anemia complementation group P aplastic anemia Esophageal atresia with or without tracheoesophageal fistula hereditary breast carcinoma congenital anemia esophageal atresia/tracheoesophageal fistula inherited aplastic anemia neurofibromatosis type 1 hematopoietic and lymphoid system neoplasm intellectual disability osteosarcoma
A	Pharos: Q96NY9	allergic rhinitis Crohn disease ovarian cancer systemic lupus erythematosus atopic eczema inflammatory bowel disease psoriasis breast carcinoma osteosarcoma skin basal cell carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.