Annotations: 7B1C

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF13855	e7b1cC1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
B [auth A]	PF13855	e7b1cA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
E [auth B]	PF13855	e7b1cB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF13855	ECOD (1.6)
C [auth D]	PF16077	e7b1cD1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF16077	ECOD (1.6)
D [auth P]	PF16077	e7b1cP1	A: few secondary structure elements	X: Cystine-knot cytokines (From Topology)	H: Cystine-knot cytokines (From Topology)	T: Cystine-knot cytokines	F: PF16077	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], E [auth B]	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
C [auth D], D [auth P]	PF16077	Spaetzle (Spaetzle)	Spaetzle	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], E [auth B]	Toll-like receptor	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	response to stimulus immune response immune system process cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway signaling positive regulation of biological process response to stimulus immune response immune system process cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway signaling positive regulation of biological process response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of innate immune response defense response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response cellular process activation of immune response	membrane cellular anatomical entity
C [auth D], D [auth P]	AAEL013433-PA	-	-	extracellular region extracellular space cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], E [auth B]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A [auth C], B [auth A], E [auth B]	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A [auth C], B [auth A], E [auth B]	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A [auth C], B [auth A], E [auth B]	IPR001611	Leucine-rich repeat	Repeat
A [auth C], B [auth A], E [auth B]	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A [auth C], B [auth A], E [auth B]	IPR017241	Toll-like receptor	Family
C [auth D], D [auth P]	IPR032104	Spaetzle	Domain
C [auth D], D [auth P]	IPR029034	Cystine-knot cytokine	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.