Annotations: 7AWT

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth I]	SCOP2B Superfamily	4Fe-4S ferredoxins	8103951	3000020	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF01058	e7awtB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: CheY-like	F: PF01058	ECOD (1.6)
C [auth E]	PF01257	e7awtE1	A: alpha bundles	X: NQO2 helical bundle domain (From Topology)	H: NQO2 helical bundle domain (From Topology)	T: NQO2 helical bundle domain	F: PF01257	ECOD (1.6)
C [auth E]	PF01257	e7awtE2	A: a+b three layers	X: Thioredoxin-like	H: Thioredoxin-like (From Topology)	T: Thioredoxin-like	F: PF01257	ECOD (1.6)
D [auth F]	PF10589	e7awtF2	A: alpha bundles	X: Bromodomain-like	H: Nqo1C-terminal domain-like (From Topology)	T: Nqo1C-terminal domain-like	F: PF10589	ECOD (1.6)
D [auth F]	F_UNCLASSIFIED	e7awtF3	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Nqo1 middle domain-like	F: F_UNCLASSIFIED	ECOD (1.6)
D [auth F]	PF01512	e7awtF1	A: a/b three-layered sandwiches	X: Nqo1 FMN-binding domain-like (From Topology)	H: Nqo1 FMN-binding domain-like (From Topology)	T: Nqo1 FMN-binding domain-like	F: PF01512	ECOD (1.6)
E [auth G]	PF01568	e7awtG2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: PF01568	ECOD (1.6)
E [auth G]	PF22117	e7awtG3	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF22117	ECOD (1.6)
E [auth G]	PF13510	e7awtG4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF13510	ECOD (1.6)
E [auth G]	PF04879	e7awtG5	A: a+b two layers	X: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	H: Formate dehydrogenase/DMSO reductase, domain 1 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domain 1	F: PF04879	ECOD (1.6)
E [auth G]	F_UNCLASSIFIED	e7awtG7	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth G]	PF00384	e7awtG1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Formate dehydrogenase/DMSO reductase, domains 2 and 3 (From Topology)	T: Formate dehydrogenase/DMSO reductase, domains 2 and 3	F: PF00384	ECOD (1.6)
E [auth G]	PF10588	e7awtG6	A: extended segments	X: iron-sulfur center-binding helical hairpin (From Topology)	H: iron-sulfur center-binding helical hairpin (From Topology)	T: iron-sulfur center-binding helical hairpin	F: PF10588	ECOD (1.6)
F [auth I]	PF00037	e7awtI1	A: a+b two layers	X: 4Fe-4S ferredoxin (From Topology)	H: 4Fe-4S ferredoxin (From Topology)	T: 4Fe-4S ferredoxin	F: PF00037	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF01058	NADH ubiquinone oxidoreductase, 20 Kd subunit (Oxidored_q6)	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	Family
B [auth D]	PF00329	Respiratory-chain NADH dehydrogenase, 30 Kd subunit (Complex1_30kDa)	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	Family
B [auth D]	PF00346	Respiratory-chain NADH dehydrogenase, 49 Kd subunit (Complex1_49kDa)	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	Family
C [auth E]	PF01257	Thioredoxin-like [2Fe-2S] ferredoxin (2Fe-2S_thioredx)	Thioredoxin-like [2Fe-2S] ferredoxin	-	Family
D [auth F]	PF01512	Respiratory-chain NADH dehydrogenase 51 Kd subunit (Complex1_51K)	Respiratory-chain NADH dehydrogenase 51 Kd subunit	-	Family
D [auth F]	PF10589	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region (NADH_4Fe-4S)	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	Domain
E [auth G]	PF01568	Molydopterin dinucleotide binding domain (Molydop_binding)	Molydopterin dinucleotide binding domain	This domain is found in various molybdopterin - containing oxidoreductases and tungsten formylmethanofuran dehydrogenase subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where the domain constitutes almost the entir ...	This domain is found in various molybdopterin - containing oxidoreductases and tungsten formylmethanofuran dehydrogenase subunit d (FwdD) and molybdenum formylmethanofuran dehydrogenase subunit (FmdD); where the domain constitutes almost the entire subunit. The formylmethanofuran dehydrogenase catalyses the first step in methane formation from CO2 in methanogenic archaea and has a molybdopterin dinucleotide cofactor [1]. This domain corresponds to the C-terminal domain IV in dimethyl sulfoxide (DMSO)reductase which interacts with the 2-amino pyrimidone ring of both molybdopterin guanine dinucleotide molecules [2].	Domain
E [auth G]	PF04879	Molybdopterin oxidoreductase Fe4S4 domain (Molybdop_Fe4S4)	Molybdopterin oxidoreductase Fe4S4 domain	This domain is found in formate dehydrogenase H for which the structure is known. This first domain (residues 1 to 60) of PDB:1aa6 is an Fe4S4 cluster just below the protein surface [1].	Domain
E [auth G]	PF00384	Molybdopterin oxidoreductase (Molybdopterin)	Molybdopterin oxidoreductase	-	Family
E [auth G]	PF13510	2Fe-2S iron-sulfur cluster binding domain (Fer2_4)	2Fe-2S iron-sulfur cluster binding domain	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. Th ...	The 2Fe-2S ferredoxin family have a general core structure consisting of beta(2)-alpha-beta(2) which a beta-grasp type fold. The domain is around one hundred amino acids with four conserved cysteine residues to which the 2Fe-2S cluster is ligated. This cluster appears within sarcosine oxidase proteins.	Domain
E [auth G]	PF10588	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region (NADH-G_4Fe-4S_3)	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	-	Domain
F [auth I]	PF00037	4Fe-4S binding domain (Fer4)	4Fe-4S binding domain	Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	NADH-quinone oxidoreductase subunit B	cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding	electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport electron transport coupled proton transport transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization energy coupled proton transmembrane transport, against electrochemical gradient monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration energy derivation by oxidation of organic compounds cellular metabolic process metabolic process generation of precursor metabolites and energy respiratory electron transport chain electron transport chain	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex plasma membrane respiratory chain complex I
B [auth D]	NADH-quinone oxidoreductase subunit C/D	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding NAD binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity binding quinone binding small molecule binding NAD binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding adenyl nucleotide binding nucleotide binding heterocyclic compound binding	cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain cellular metabolic process electron transport chain metabolic process cellular process generation of precursor metabolites and energy	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex plasma membrane respiratory chain complex I intracellular anatomical structure cytoplasm
C [auth E]	NADH-quinone oxidoreductase subunit E	oxidoreductase activity catalytic activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding quinone binding cation binding ion binding metal ion binding	cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain cellular metabolic process electron transport chain metabolic process cellular process generation of precursor metabolites and energy	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex plasma membrane respiratory chain complex I
D [auth F]	NADH-quinone oxidoreductase subunit F	binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity quinone binding NAD binding purine nucleotide binding adenyl nucleotide binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding cation binding metal ion binding	aerobic respiration cellular respiration energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy respiratory electron transport chain electron transport chain	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex plasma membrane respiratory chain complex I
E [auth G]	NADH-quinone oxidoreductase	electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding quinone binding electron transfer activity NADH dehydrogenase (ubiquinone) activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity primary active transmembrane transporter activity transporter activity transmembrane transporter activity iron-sulfur cluster binding binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding 2 iron, 2 sulfur cluster binding quinone binding organic cyclic compound binding molybdopterin cofactor binding cation binding ion binding metal ion binding	aerobic respiration cellular respiration energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy oxidative phosphorylation ATP synthesis coupled electron transport electron transport chain respiratory electron transport chain	membrane cellular anatomical entity cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex catalytic complex membrane protein complex oxidoreductase complex NADH dehydrogenase complex respiratory chain complex plasma membrane protein complex plasma membrane respirasome membrane cellular anatomical entity cell periphery plasma membrane intracellular anatomical structure cytoplasm protein-containing complex catalytic complex membrane protein complex oxidoreductase complex NADH dehydrogenase complex respiratory chain complex plasma membrane protein complex plasma membrane respirasome transporter complex transmembrane transporter complex respiratory chain complex I respirasome plasma membrane respiratory chain complex I
F [auth I]	NADH-quinone oxidoreductase subunit I	cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding quinone binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H cation binding transition metal ion binding iron ion binding ion binding binding metal ion binding small molecule binding quinone binding iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding oxidoreductase activity NADH:ubiquinone reductase (non-electrogenic) activity oxidoreductase activity, acting on NAD(P)H catalytic activity oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor NADH dehydrogenase activity	aerobic respiration cellular respiration energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy respiratory electron transport chain electron transport chain	membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I membrane cellular anatomical entity respiratory chain complex protein-containing complex catalytic complex plasma membrane protein complex plasma membrane respirasome plasma membrane membrane protein complex transporter complex NADH dehydrogenase complex cell periphery transmembrane transporter complex respiratory chain complex I respirasome oxidoreductase complex plasma membrane respiratory chain complex I

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR006137	NADH:ubiquinone oxidoreductase-like, 20kDa subunit	Domain
A [auth B]	IPR006138	NADH-ubiquinone oxidoreductase, 20 Kd subunit	Family
B [auth D]	IPR037232	NADH:ubiquinone oxidoreductase, 30kDa subunit superfamily	Homologous Superfamily
B [auth D]	IPR023062	NADH dehydrogenase, subunit CD	Family
B [auth D]	IPR014029	NADH:ubiquinone oxidoreductase, 49kDa subunit, conserved site	Conserved Site
B [auth D]	IPR029014	[NiFe]-hydrogenase, large subunit	Homologous Superfamily
B [auth D]	IPR022885	NAD(P)H-quinone oxidoreductase subunit D/H	Family
B [auth D]	IPR001268	NADH:ubiquinone oxidoreductase, 30kDa subunit	Domain
B [auth D]	IPR001135	NADH-quinone oxidoreductase, subunit D	Domain
B [auth D]	IPR020396	NADH:ubiquinone oxidoreductase, 30kDa subunit, conserved site	Conserved Site
B [auth D]	IPR010218	NADH dehydrogenase, subunit C	Family
C [auth E]	IPR041921	NADH-quinone oxidoreductase subunit E, N-terminal	Homologous Superfamily
C [auth E]	IPR042128	NuoE domain	Domain
C [auth E]	IPR002023	NADH-quinone oxidoreductase subunit E-like	Family
C [auth E]	IPR036249	Thioredoxin-like superfamily	Homologous Superfamily
D [auth F]	IPR019575	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain	Domain
D [auth F]	IPR011537	NADH ubiquinone oxidoreductase, F subunit	Family
D [auth F]	IPR001949	NADH:ubiquinone oxidoreductase, 51kDa subunit, conserved site	Conserved Site
D [auth F]	IPR037225	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain superfamily	Homologous Superfamily
D [auth F]	IPR037207	NADH-ubiquinone oxidoreductase 51kDa subunit, iron-sulphur binding domain superfamily	Homologous Superfamily
D [auth F]	IPR011538	NADH-ubiquinone oxidoreductase 51kDa subunit, FMN-binding domain	Domain
E [auth G]	IPR006963	Molybdopterin oxidoreductase, 4Fe-4S domain	Domain
E [auth G]	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
E [auth G]	IPR010228	NADH:ubiquinone oxidoreductase, subunit G	Family
E [auth G]	IPR009010	Aspartate decarboxylase-like domain superfamily	Homologous Superfamily
E [auth G]	IPR006657	Molybdopterin dinucleotide-binding domain	Domain
E [auth G]	IPR006656	Molybdopterin oxidoreductase	Domain
E [auth G]	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
E [auth G]	IPR000283	NADH:ubiquinone oxidoreductase, 75kDa subunit, conserved site	Conserved Site
E [auth G]	IPR019574	NADH:ubiquinone oxidoreductase, subunit G, iron-sulphur binding	Domain
F [auth I]	IPR010226	NADH-quinone oxidoreductase, chain I	Family
F [auth I]	IPR017900	4Fe-4S ferredoxin, iron-sulphur binding, conserved site	Conserved Site
F [auth I]	IPR017896	4Fe-4S ferredoxin-type, iron-sulphur binding domain	Domain

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth B], B [auth D], E [auth G], F [auth I]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Electron Transport Chain Complexes: Complex I	Complex I peripheral arm