Annotations: 7APK

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	PF00400	e7apkC1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
J [auth K]	PF00400	e7apkK1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
R [auth c]	PF00400	e7apkc1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
Y [auth k]	PF00400	e7apkk1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
AA [auth n]	PF00400	e7apkn1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
T [auth f]	PF00400	e7apkf1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
E [auth F]	PF00400	e7apkF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
L [auth N]	PF00400	e7apkN1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
CA [auth p]	PF00271	e7apkp1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
G [auth H]	PF00271	e7apkH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
N [auth P]	PF00271	e7apkP1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
V [auth h]	PF00271	e7apkh1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B, I [auth J], Q [auth b], X [auth j]	PF11262	Transcription factor/nuclear export subunit protein 2 (Tho2)	Transcription factor/nuclear export subunit protein 2	-	Family
B, I [auth J], Q [auth b], X [auth j]	PF11732	Transcription- and export-related complex subunit (Thoc2)	Transcription- and export-related complex subunit	-	Family
C, J [auth K], R [auth c], Y [auth k]	PF12894	Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)	Anaphase-promoting complex subunit 4 WD40 domain	-	Repeat
C, J [auth K], R [auth c], Y [auth k]	PF07676	WD40-like Beta Propeller Repeat (PD40)	WD40-like Beta Propeller Repeat	-	Repeat
C, J [auth K], R [auth c], Y [auth k]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
D [auth E], K [auth M], S [auth e], Z [auth m]	PF09766	Fms-interacting protein/Thoc5 (FmiP_Thoc5)	Fms-interacting protein/Thoc5	-	Family
AA [auth n], E [auth F], L [auth N], T [auth f]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
BA [auth o], F [auth G], M [auth O], U [auth g]	PF05615	Tho complex subunit 7 (THOC7)	Tho complex subunit 7	-	Family
CA [auth p], G [auth H], N [auth P], V [auth h]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, H [auth I], P [auth a], W [auth i]	THO complex subunit 1	DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization apoptotic process cell death programmed cell death regulation of cellular process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression DNA-templated transcription elongation organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process mRNA processing mRNA metabolic process cellular response to stimulus response to stimulus signaling signal transduction cell communication	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck nuclear body nucleoplasm protein-containing complex transcription export complex nuclear protein-containing complex THO complex THO complex part of transcription export complex cytoplasm
B, I [auth J], Q [auth b], X [auth j]	THO complex subunit 2	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport poly(A)+ mRNA export from nucleus intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization developmental process anatomical structure morphogenesis anatomical structure development cell morphogenesis regulation of localization regulation of cellular process regulation of mRNA export from nucleus ribonucleoprotein complex localization regulation of intracellular transport regulation of ribonucleoprotein complex localization regulation of biological process regulation of transport regulation of RNA export from nucleus regulation of nucleobase-containing compound transport biological regulation regulation of nucleocytoplasmic transport regulation of cellular localization multicellular organismal process cellular developmental process nervous system development generation of neurons neurogenesis multicellular organism development cell differentiation system development regulation of biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of cellular biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of metabolic process stem cell division cell division embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development blastocyst development mRNA processing mRNA metabolic process regulation of neuron projection development regulation of cellular component organization cell projection organization negative regulation of biological process cell development neuron projection development cellular component organization neuron differentiation negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization negative regulation of neuron projection development neuron development regulation of plasma membrane bounded cell projection organization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription export complex nuclear protein-containing complex THO complex THO complex part of transcription export complex
C, J [auth K], R [auth c], Y [auth k]	THO complex subunit 3	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription export complex nuclear protein-containing complex THO complex THO complex part of transcription export complex
D [auth E], K [auth M], S [auth e], Z [auth m]	THO complex subunit 5 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of DNA-templated transcription elongation regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process DNA-templated transcription elongation positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis cell development mononuclear cell differentiation myeloid cell differentiation cell differentiation anatomical structure development monocyte differentiation leukocyte differentiation multicellular organismal process primitive hemopoiesis animal organ development embryo development multicellular organism development embryonic hemopoiesis embryonic organ development mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular organelle protein-containing complex transcription export complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity THO complex THO complex part of transcription export complex cytoplasm membrane-enclosed lumen membrane-bounded organelle intracellular organelle protein-containing complex transcription export complex intracellular anatomical structure organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity THO complex THO complex part of transcription export complex cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
AA [auth n], E [auth F], L [auth N], T [auth f]	THO complex subunit 6 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization apoptotic process cell death programmed cell death mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex transcription export complex nuclear protein-containing complex THO complex THO complex part of transcription export complex
BA [auth o], F [auth G], M [auth O], U [auth g]	THO complex subunit 7 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex transcription export complex nuclear protein-containing complex THO complex THO complex part of transcription export complex
CA [auth p], G [auth H], N [auth P], V [auth h]	Spliceosome RNA helicase DDX39B	RNA binding U6 snRNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U4 snRNA binding protein binding ATP-dependent protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding RNA binding U6 snRNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U4 snRNA binding protein binding ATP-dependent protein binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ATP-dependent activity, acting on RNA ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity RNA helicase activity identical protein binding	nucleobase-containing compound metabolic process RNA secondary structure unwinding organic cyclic compound metabolic process organic substance metabolic process RNA metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nucleobase-containing compound metabolic process RNA secondary structure unwinding organic cyclic compound metabolic process organic substance metabolic process RNA metabolic process metabolic process primary metabolic process macromolecule metabolic process nucleic acid metabolic process cellular localization nitrogen compound transport nucleocytoplasmic transport transport cellular biosynthetic process nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell organic substance biosynthetic process RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport cellular metabolic process nucleic acid transport intracellular transport gene expression establishment of localization macromolecule biosynthetic process RNA export from nucleus establishment of RNA localization biosynthetic process macromolecule localization cellular process RNA splicing RNA processing ribonucleoprotein complex biogenesis mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen U6 snRNP transcription export complex cytoplasm spliceosomal complex
DA [auth x], O [auth X]	THOC2 anchor (putative)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, H [auth I], P [auth a], W [auth i]	IPR011029	Death-like domain superfamily	Homologous Superfamily
A, H [auth I], P [auth a], W [auth i]	IPR000488	Death domain	Domain
A, H [auth I], P [auth a], W [auth i]	IPR021861	THO complex, subunit THOC1	Family
B, I [auth J], Q [auth b], X [auth j]	IPR040007	THO complex subunit 2	Family
B, I [auth J], Q [auth b], X [auth j]	IPR032302	THO complex subunit 2, N-terminal domain	Domain
B, I [auth J], Q [auth b], X [auth j]	IPR021418	THO complex, subunitTHOC2, C-terminal	Domain
B, I [auth J], Q [auth b], X [auth j]	IPR021726	THO complex, subunitTHOC2, N-terminal	Domain
C, J [auth K], R [auth c], Y [auth k]	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
C, J [auth K], R [auth c], Y [auth k]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C, J [auth K], R [auth c], Y [auth k]	IPR011659	WD40-like beta propeller	Repeat
C, J [auth K], R [auth c], Y [auth k]	IPR001680	WD40 repeat	Repeat
C, J [auth K], R [auth c], Y [auth k]	IPR020472	G-protein beta WD-40 repeat	Repeat
C, J [auth K], R [auth c], Y [auth k]	IPR040132	TREX component Tex1/THOC3	Family
C, J [auth K], R [auth c], Y [auth k]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
D [auth E], K [auth M], S [auth e], Z [auth m]	IPR019163	THO complex, subunit 5	Family
AA [auth n], E [auth F], L [auth N], T [auth f]	IPR019775	WD40 repeat, conserved site	Conserved Site
AA [auth n], E [auth F], L [auth N], T [auth f]	IPR042626	THO complex subunit 6	Family
AA [auth n], E [auth F], L [auth N], T [auth f]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
AA [auth n], E [auth F], L [auth N], T [auth f]	IPR001680	WD40 repeat	Repeat
AA [auth n], E [auth F], L [auth N], T [auth f]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
BA [auth o], F [auth G], M [auth O], U [auth g]	IPR008501	THO complex subunit 7/Mft1	Family
CA [auth p], G [auth H], N [auth P], V [auth h]	IPR014014	RNA helicase, DEAD-box type, Q motif	Domain
CA [auth p], G [auth H], N [auth P], V [auth h]	IPR011545	DEAD/DEAH box helicase domain	Domain
CA [auth p], G [auth H], N [auth P], V [auth h]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
CA [auth p], G [auth H], N [auth P], V [auth h]	IPR001650	Helicase, C-terminal domain-like	Domain
CA [auth p], G [auth H], N [auth P], V [auth h]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, H [auth I], P [auth a], W [auth i]	Pharos: Q96FV9	malignant mesothelioma medulloblastoma
B, I [auth J], Q [auth b], X [auth j]	Pharos: Q8NI27	X-linked intellectual disability-short stature-overweight syndrome intellectual disability ulcerative colitis adenoma glioblastoma lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor malignant ependymoma MENTAL RETARDATION, X-LINKED 35 pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia X-linked intellectual disability-short stature-overweight syndrome intellectual disability ulcerative colitis adenoma glioblastoma lung cancer medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor astrocytic tumor malignant ependymoma MENTAL RETARDATION, X-LINKED 35 pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia rheumatoid arthritis atypical teratoid rhabdoid tumor large cell medulloblastoma malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma
D [auth E], K [auth M], S [auth e], Z [auth m]	Pharos: Q13769	lung cancer medulloblastoma malignant mesothelioma osteosarcoma Malignant neoplasm of breast ovarian cancer
AA [auth n], E [auth F], L [auth N], T [auth f]	Pharos: Q86W42	THOC6-related developmental delay-microcephaly-facial dysmorphism syndrome intellectual disability malignant mesothelioma medulloblastoma
BA [auth o], F [auth G], M [auth O], U [auth g]	Pharos: Q6I9Y2	astrocytic tumor hereditary spastic paraplegia psoriasis breast cancer lymphoplasmacytic lymphoma diabetes mellitus plasma cell myeloma
CA [auth p], G [auth H], N [auth P], V [auth h]	Pharos: Q13838	psoriasis Stevens-Johnson syndrome AIDS cancer Crohn disease herpes zoster hypertensive disorder lung carcinoma myasthenia gravis psoriatic arthritis ulcerative colitis allergic rhinitis carpal tunnel syndrome Dengue hemorrhagic fever HIV infectious disease psoriasis Stevens-Johnson syndrome AIDS cancer Crohn disease herpes zoster hypertensive disorder lung carcinoma myasthenia gravis psoriatic arthritis ulcerative colitis allergic rhinitis carpal tunnel syndrome Dengue hemorrhagic fever HIV infectious disease laryngeal squamous cell carcinoma membranous glomerulonephritis myositis squamous cell lung carcinoma autism spectrum disorder cervical cancer Hashimoto thyroiditis Hodgkins lymphoma liver disease metabolic syndrome X