Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
Y [auth k]PF00400e7apkk1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
CPF00400e7apkC1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
J [auth K]PF00400e7apkK1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
R [auth c]PF00400e7apkc1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
AA [auth n]PF00400e7apkn1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
L [auth N]PF00400e7apkN1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
T [auth f]PF00400e7apkf1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
E [auth F]PF00400e7apkF1 A: beta duplicates or obligate multimersX: beta-propeller-likeH: beta-propellerT: 7-bladedF: PF00400ECOD (1.6)
CA [auth p]PF00271e7apkp1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00271ECOD (1.6)
N [auth P]PF00271e7apkP1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00271ECOD (1.6)
V [auth h]PF00271e7apkh1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00271ECOD (1.6)
G [auth H]PF00271e7apkH1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: PF00271ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B,
I [auth J],
Q [auth b],
X [auth j]
PF11262Transcription factor/nuclear export subunit protein 2 (Tho2)Transcription factor/nuclear export subunit protein 2- Family
B,
I [auth J],
Q [auth b],
X [auth j]
PF11732Transcription- and export-related complex subunit (Thoc2)Transcription- and export-related complex subunit- Family
C,
J [auth K],
R [auth c],
Y [auth k]
PF12894Anaphase-promoting complex subunit 4 WD40 domain (ANAPC4_WD40)Anaphase-promoting complex subunit 4 WD40 domain- Repeat
C,
J [auth K],
R [auth c],
Y [auth k]
PF07676WD40-like Beta Propeller Repeat (PD40)WD40-like Beta Propeller Repeat- Repeat
C,
J [auth K],
R [auth c],
Y [auth k]
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
D [auth E],
K [auth M],
S [auth e],
Z [auth m]
PF09766Fms-interacting protein/Thoc5 (FmiP_Thoc5)Fms-interacting protein/Thoc5- Family
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
PF00400WD domain, G-beta repeat (WD40)WD domain, G-beta repeat- Repeat
BA [auth o],
F [auth G],
M [auth O],
U [auth g]
PF05615Tho complex subunit 7 (THOC7)Tho complex subunit 7- Family
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
PF00271Helicase conserved C-terminal domain (Helicase_C)Helicase conserved C-terminal domainThe Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
H [auth I],
P [auth a],
W [auth i]
THO complex subunit 1
B,
I [auth J],
Q [auth b],
X [auth j]
THO complex subunit 2
C,
J [auth K],
R [auth c],
Y [auth k]
THO complex subunit 3
D [auth E],
K [auth M],
S [auth e],
Z [auth m]
THO complex subunit 5 homolog
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
THO complex subunit 6 homolog
BA [auth o],
F [auth G],
M [auth O],
U [auth g]
THO complex subunit 7 homolog
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
Spliceosome RNA helicase DDX39B
DA [auth x],
O [auth X]
THOC2 anchor (putative)---

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
H [auth I],
P [auth a],
W [auth i]
IPR011029Death-like domain superfamilyHomologous Superfamily
A,
H [auth I],
P [auth a],
W [auth i]
IPR000488Death domainDomain
A,
H [auth I],
P [auth a],
W [auth i]
IPR021861THO complex, subunit THOC1Family
B,
I [auth J],
Q [auth b],
X [auth j]
IPR040007THO complex subunit 2Family
B,
I [auth J],
Q [auth b],
X [auth j]
IPR032302THO complex subunit 2, N-terminal domainDomain
B,
I [auth J],
Q [auth b],
X [auth j]
IPR021418THO complex, subunitTHOC2, C-terminalDomain
B,
I [auth J],
Q [auth b],
X [auth j]
IPR021726THO complex, subunitTHOC2, N-terminalDomain
C,
J [auth K],
R [auth c],
Y [auth k]
IPR024977Anaphase-promoting complex subunit 4-like, WD40 domainDomain
C,
J [auth K],
R [auth c],
Y [auth k]
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
C,
J [auth K],
R [auth c],
Y [auth k]
IPR011659WD40-like beta propellerRepeat
C,
J [auth K],
R [auth c],
Y [auth k]
IPR001680WD40 repeatRepeat
C,
J [auth K],
R [auth c],
Y [auth k]
IPR020472G-protein beta WD-40 repeatRepeat
C,
J [auth K],
R [auth c],
Y [auth k]
IPR040132TREX component Tex1/THOC3Family
C,
J [auth K],
R [auth c],
Y [auth k]
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
D [auth E],
K [auth M],
S [auth e],
Z [auth m]
IPR019163THO complex, subunit 5Family
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
IPR019775WD40 repeat, conserved siteConserved Site
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
IPR042626THO complex subunit 6Family
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
IPR036322WD40-repeat-containing domain superfamilyHomologous Superfamily
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
IPR001680WD40 repeatRepeat
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
IPR015943WD40/YVTN repeat-like-containing domain superfamilyHomologous Superfamily
BA [auth o],
F [auth G],
M [auth O],
U [auth g]
IPR008501THO complex subunit 7/Mft1Family
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
IPR014014RNA helicase, DEAD-box type, Q motifDomain
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
IPR011545DEAD/DEAH box helicase domainDomain
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
IPR027417P-loop containing nucleoside triphosphate hydrolaseHomologous Superfamily
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
IPR001650Helicase, C-terminal domain-likeDomain
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
IPR014001Helicase superfamily 1/2, ATP-binding domainDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A,
H [auth I],
P [auth a],
W [auth i]
PharosQ96FV9
B,
I [auth J],
Q [auth b],
X [auth j]
PharosQ8NI27
D [auth E],
K [auth M],
S [auth e],
Z [auth m]
PharosQ13769
AA [auth n],
E [auth F],
L [auth N],
T [auth f]
PharosQ86W42
BA [auth o],
F [auth G],
M [auth O],
U [auth g]
PharosQ6I9Y2
CA [auth p],
G [auth H],
N [auth P],
V [auth h]
PharosQ13838