Annotations: 7ABI

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth E]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	WD40 repeat-like	8052534	3001694	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	WD40 repeat-like	8052535	3001694	SCOP2B (2022-06-29)
B [auth E]	SCOP2B Superfamily	WD40 repeat-like	8051197	3001694	SCOP2B (2022-06-29)
C [auth b]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063452	3000419	SCOP2B (2022-06-29)
HA [auth i]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063452	3000419	SCOP2B (2022-06-29)
D [auth W]	SCOP2B Superfamily	L domain-like	8043993	3001010	SCOP2B (2022-06-29)
E [auth w]	SCOP2B Superfamily	RNA-binding domain RBD	8090834	3000110	SCOP2B (2022-06-29)
NA [auth k]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
F [auth d]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063468	3000419	SCOP2B (2022-06-29)
G [auth U]	SCOP2B Superfamily	ARM repeat-like	8090869	3000116	SCOP2B (2022-06-29)
G [auth U]	SCOP2B Superfamily	Upf1 beta-barrel domain-like	8090870	3002168	SCOP2B (2022-06-29)
G [auth U]	SCOP2B Superfamily	RecA-like P-loop NTPases	8090871	3002019	SCOP2B (2022-06-29)
G [auth U]	SCOP2B Superfamily	RecA-like P-loop NTPases	8090872	3002019	SCOP2B (2022-06-29)
J [auth B]	SCOP2B Superfamily	RNA-binding domain RBD	8035327	3000110	SCOP2B (2022-06-29)
K [auth z]	SCOP2B Superfamily	RNA-binding domain RBD	8040695	3000110	SCOP2B (2022-06-29)
L [auth q]	SCOP2B Superfamily	Ubiquitin-like	8038047	3000157	SCOP2B (2022-06-29)
M [auth s]	SCOP2B Superfamily	E set domains	8055093	3000070	SCOP2B (2022-06-29)
M [auth s]	SCOP2B Superfamily	Brl domain-like	8036193	3000115	SCOP2B (2022-06-29)
P [auth 0]	SCOP2B Superfamily	SMAD/FHA domain-like	8100246	3000137	SCOP2B (2022-06-29)
R [auth 1]	SCOP2B Superfamily	RNA-binding domain RBD	8061967	3000110	SCOP2B (2022-06-29)
S [auth L]	SCOP2B Superfamily	Homeodomain-like	8089608	3000001	SCOP2B (2022-06-29)
X [auth Y]	SCOP2B Superfamily	PWI domain	8036462	3000964	SCOP2B (2022-06-29)
Y [auth 7]	SCOP2B Superfamily	Winged helix DNA-binding domain	8052331	3000034	SCOP2B (2022-06-29)
CA [auth y]	SCOP2B Superfamily	Triquetra zinc finger motif	8051848	3002040	SCOP2B (2022-06-29)
FA [auth h]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
ZA [auth a]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041749	3000419	SCOP2B (2022-06-29)
IA [auth t]	SCOP2B Superfamily	Cyclophilin-like	8035793	3000168	SCOP2B (2022-06-29)
JA [auth m]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041747	3000419	SCOP2B (2022-06-29)
VA [auth f]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041747	3000419	SCOP2B (2022-06-29)
LA [auth l]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
BB [auth e]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041751	3000419	SCOP2B (2022-06-29)
MA [auth A]	SCOP2B Superfamily	JAB1/MPN domain-like	8053277	3001105	SCOP2B (2022-06-29)
MA [auth A]	SCOP2B Superfamily	Ribonuclease H-like	8041105	3000143	SCOP2B (2022-06-29)
PA [auth j]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063476	3000419	SCOP2B (2022-06-29)
DB [auth c]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8063476	3000419	SCOP2B (2022-06-29)
XA [auth g]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
RA [auth n]	SCOP2B Superfamily	Sm-like ribonucleoproteins	8041748	3000419	SCOP2B (2022-06-29)
SA [auth P]	SCOP2B Superfamily	RNA-binding domain RBD	8064957	3000110	SCOP2B (2022-06-29)
UA [auth p]	SCOP2B Superfamily	Surp module (SWAP domain)	8033803	3001401	SCOP2B (2022-06-29)
GA [auth o]	SCOP2B Superfamily	RNA-binding domain RBD	8039202	3000110	SCOP2B (2022-06-29)
GA [auth o]	SCOP2B Superfamily	Cyclophilin-like	8035984	3000168	SCOP2B (2022-06-29)
QA [auth I]	SCOP2B Superfamily	PRP38-like	8055808	3002318	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	PF00400	e7abiD1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
B [auth E]	PF03178,PF10433	e7abiE3	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF03178,PF10433	ECOD (1.6)
B [auth E]	PF10433	e7abiE2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF10433	ECOD (1.6)
B [auth E]	PF03178	e7abiE1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF03178	ECOD (1.6)
C [auth b]	PF01423	e7abib1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
HA [auth i]	PF01423	e7abii1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
D [auth W]	PF14580	e7abiW1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: PF14580	ECOD (1.6)
E [auth w]	PF00076	e7abiw1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
NA [auth k]	PF01423	e7abik1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
F [auth d]	PF01423	e7abid1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
G [auth U]	PF21143	e7abiU5	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF21143	ECOD (1.6)
G [auth U]	PF16399	e7abiU3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF16399	ECOD (1.6)
G [auth U]	PF21144	e7abiU2	A: a+b two layers	X: Spliceosomal helicase Aquarius insert domain (From Topology)	H: Spliceosomal helicase Aquarius insert domain (From Topology)	T: Spliceosomal helicase Aquarius insert domain	F: PF21144	ECOD (1.6)
G [auth U]	PF13086	e7abiU4	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF13086	ECOD (1.6)
G [auth U]	PF13087	e7abiU1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF13087	ECOD (1.6)
H [auth x]	PF07189	e7abix1	A: alpha arrays	X: RDS3 complex subunit 10 (From Topology)	H: RDS3 complex subunit 10 (From Topology)	T: RDS3 complex subunit 10	F: PF07189	ECOD (1.6)
J [auth B]	PF00076	e7abiB1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
K [auth z]	PF00076	e7abiz1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
L [auth q]	PF00240	e7abiq1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF00240	ECOD (1.6)
M [auth s]	PF02889	e7abis9	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF02889	ECOD (1.6)
M [auth s]	F_UNCLASSIFIED	e7abis10	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
M [auth s]	F_UNCLASSIFIED	e7abis7	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: F_UNCLASSIFIED	ECOD (1.6)
M [auth s]	PF02889	e7abis3	A: alpha arrays	X: Sec63 N-terminal subdomain-like (From Topology)	H: Sec63 N-terminal subdomain-like (From Topology)	T: Sec63 N-terminal subdomain-like	F: PF02889	ECOD (1.6)
M [auth s]	PF00270	e7abis11	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00270	ECOD (1.6)
M [auth s]	PF00271	e7abis5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
P [auth 0]	PF00498	e7abi01	A: beta sandwiches	X: SMAD/FHA domain (From Topology)	H: SMAD/FHA domain (From Topology)	T: SMAD/FHA domain	F: PF00498	ECOD (1.6)
Q	PF01125	e7abiQ1	A: few secondary structure elements	X: Pre-mRNA-splicing factor BUD31 (From Topology)	H: Pre-mRNA-splicing factor BUD31 (From Topology)	T: Pre-mRNA-splicing factor BUD31	F: PF01125	ECOD (1.6)
R [auth 1]	PF00076	e7abi11	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
S [auth L]	PF00249	e7abiL2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00249	ECOD (1.6)
T [auth N]	PF12171	e7abiN1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PF12171	ECOD (1.6)
U [auth S]	PF08216	e7abiS1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08216	ECOD (1.6)
V [auth r]	PF03144	e7abir2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: Alanine racemase-C	F: PF03144	ECOD (1.6)
V [auth r]	PF03764	e7abir3	A: a+b two layers	X: Ribosomal protein S5 domain 2-like (From Topology)	H: Ribosomal protein S5 domain 2-like (From Topology)	T: Ribosomal protein S5 domain 2-like	F: PF03764	ECOD (1.6)
V [auth r]	PF00679	e7abir1	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF00679	ECOD (1.6)
V [auth r]	PF14492	e7abir4	A: a+b two layers	X: Alpha-beta plaits	H: EF-G C-terminal domain-like (From Topology)	T: EF-G C-terminal domain-like	F: PF14492	ECOD (1.6)
V [auth r]	PF00009,PF16004	e7abir5	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00009,PF16004	ECOD (1.6)
X [auth Y]	PF01480	e7abiY1	A: alpha arrays	X: PWI domain-like	H: PWI domain (From Topology)	T: PWI domain	F: PF01480	ECOD (1.6)
Y [auth 7]	PF18131	e7abi71	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF18131	ECOD (1.6)
Y [auth 7]	PF10357	e7abi72	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF10357	ECOD (1.6)
Z [auth M]	F_UNCLASSIFIED	e7abiM1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: F_UNCLASSIFIED	ECOD (1.6)
BA [auth O]	PF02184	e7abiO1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02184	ECOD (1.6)
CA [auth y]	PF03660	e7abiy1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: PHD finger-like domain-containing protein 5A	F: PF03660	ECOD (1.6)
EA [auth G]	PF00400	e7abiG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: PF00400	ECOD (1.6)
FA [auth h]	PF01423	e7abih1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
ZA [auth a]	PF01423	e7abia1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
IA [auth t]	PF00160	e7abit1	A: beta barrels	X: Cyclophilin-like (From Topology)	H: Cyclophilin-like (From Topology)	T: Cyclophilin-like	F: PF00160	ECOD (1.6)
IA [auth t]	F_UNCLASSIFIED	e7abit2	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: F_UNCLASSIFIED	ECOD (1.6)
IA [auth t]	F_UNCLASSIFIED	e7abit3	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: RING/U-box	F: F_UNCLASSIFIED	ECOD (1.6)
JA [auth m]	PF01423	e7abim1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
VA [auth f]	PF01423	e7abif1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
LA [auth l]	PF01423	e7abil1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
BB [auth e]	PF01423	e7abie1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
MA [auth A]	PF10596,PF10597	e7abiA4	A: alpha bundles	X: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	H: helical bundle domain in reverse transcriptase-like polymerases (From Topology)	T: helical bundle domain in reverse transcriptase-like polymerases	F: PF10596,PF10597	ECOD (1.6)
MA [auth A]	PF08082,PF08083	e7abiA2	A: alpha complex topology	X: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	H: Pre-mRNA-splicing factor 8 N-terminal domain (From Topology)	T: Pre-mRNA-splicing factor 8 N-terminal domain	F: PF08082,PF08083	ECOD (1.6)
MA [auth A]	PF10598	e7abiA6	A: a+b two layers	X: Alpha-beta plaits	H: Adenylyl and guanylyl cyclase catalytic domain-like	T: Adenylyl and guanylyl cyclase catalytic domain-like	F: PF10598	ECOD (1.6)
MA [auth A]	PF01398,PF08084	e7abiA3	A: a+b three layers	X: Cytidine deaminase-like (From Topology)	H: Cytidine deaminase-like (From Topology)	T: Cytidine deaminase-like	F: PF01398,PF08084	ECOD (1.6)
MA [auth A]	PF10596	e7abiA1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: PF10596	ECOD (1.6)
MA [auth A]	PF12134	e7abiA5	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF12134	ECOD (1.6)
PA [auth j]	PF01423	e7abij1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
DB [auth c]	PF01423	e7abic1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
XA [auth g]	PF01423	e7abig1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
RA [auth n]	PF01423	e7abin1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: PF01423	ECOD (1.6)
SA [auth P]	PF00076	e7abiP3	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
SA [auth P]	PF21369	e7abiP1	A: few secondary structure elements	X: RING/U-box-like	H: RING/U-box-like	T: FYVE/PHD zinc finger	F: PF21369	ECOD (1.6)
SA [auth P]	PF18345	e7abiP2	A: few secondary structure elements	X: CCCH zinc finger	H: CCCH zinc finger (From Topology)	T: CCCH zinc finger	F: PF18345	ECOD (1.6)
UA [auth p]	PF01805	e7abip2	A: alpha bundles	X: Surp module (SWAP domain) (From Topology)	H: Surp module (SWAP domain) (From Topology)	T: Surp module (SWAP domain)	F: PF01805	ECOD (1.6)
WA [auth F]	PF16835	e7abiF2	A: beta sandwiches	X: HSP20-like	H: Pre-mRNA-splicing factor PRP11 C-terminal domain (From Topology)	T: Pre-mRNA-splicing factor PRP11 C-terminal domain	F: PF16835	ECOD (1.6)
WA [auth F]	PF12874	e7abiF1	A: few secondary structure elements	X: beta-beta-alpha zinc fingers	H: beta-beta-alpha zinc fingers (From Topology)	T: beta-beta-alpha zinc fingers	F: PF12874	ECOD (1.6)
AB [auth u]	PF08920,PF22646	e7abiu1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08920,PF22646	ECOD (1.6)
GA [auth o]	PF00160	e7abio2	A: beta barrels	X: Cyclophilin-like (From Topology)	H: Cyclophilin-like (From Topology)	T: Cyclophilin-like	F: PF00160	ECOD (1.6)
GA [auth o]	PF00076	e7abio1	A: a+b two layers	X: Alpha-beta plaits	H: RNA-binding domain, RBD (From Topology)	T: RNA-binding domain, RBD	F: PF00076	ECOD (1.6)
QA [auth I]	PF03371	e7abiI1	A: alpha superhelices	X: Repetitive alpha hairpins	H: Pre-mRNA-splicing factor 38A (From Topology)	T: Pre-mRNA-splicing factor 38A	F: PF03371	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
B [auth E]	PF10433	Mono-functional DNA-alkylating methyl methanesulfonate N-term (MMS1_N)	Mono-functional DNA-alkylating methyl methanesulfonate N-term	-	Repeat
B [auth E]	PF03178	CPSF A subunit region (CPSF_A)	CPSF A subunit region	-	Repeat
C [auth b], HA [auth i]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
D [auth W]	PF14580	Leucine-rich repeat (LRR_9)	Leucine-rich repeat	-	Repeat
E [auth w]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
F [auth d], NA [auth k]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
G [auth U]	PF21144	Intron-binding protein aquarius insert domain (Aquarius_N_3rd)	Intron-binding protein aquarius insert domain	This entry represents the insert domain of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly [1,2].	Domain
G [auth U]	PF21143	Intron-binding protein aquarius, beta-barrel (Aquarius_N_2nd)	Intron-binding protein aquarius, beta-barrel	This entry represents the beta-barrel domain found at the N-terminal of intron-binding protein aquarius, a splicing factor which links excision of introns from pre-mRNA with snoRP assembly [1,2].	Domain
G [auth U]	PF13086	AAA domain (AAA_11)	AAA domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	Domain
G [auth U]	PF13087	AAA domain (AAA_12)	AAA domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily. Many of the proteins in this family are conjugative transfer proteins.	Domain
G [auth U]	PF16399	Intron-binding protein aquarius N-terminal (Aquarius_N_1st)	Intron-binding protein aquarius N-terminal	-	Repeat
H [auth x]	PF07189	Splicing factor 3B subunit 10 (SF3b10) (SF3b10)	Splicing factor 3B subunit 10 (SF3b10)	-	Family
J [auth B]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
K [auth z]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
L [auth q]	PF00240	Ubiquitin family (ubiquitin)	Ubiquitin family	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry ...	This family contains a number of ubiquitin-like proteins: SUMO (smt3 homologue) (see Swiss:Q02724), Nedd8 (see Swiss:P29595), Elongin B (see Swiss:Q15370), Rub1 (see Swiss:Q9SHE7), and Parkin (see Swiss:O60260). A number of them are thought to carry a distinctive five-residue motif termed the proteasome-interacting motif (PIM), which may have a biologically significant role in protein delivery to proteasomes and recruitment of proteasomes to transcription sites [5].	Domain
M [auth s]	PF02889	Sec63 Brl domain (Sec63)	Sec63 Brl domain	-	Family
M [auth s]	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
M [auth s]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain
O [auth 3]	PF09736	Pre-mRNA-splicing factor of RES complex (Bud13)	Pre-mRNA-splicing factor of RES complex	-	Family
P [auth 0]	PF00498	FHA domain (FHA)	FHA domain	-	Family
Q	PF01125	Pre-mRNA-splicing factor BUD31 (BUD31)	Pre-mRNA-splicing factor BUD31	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role ...	This entry includes Pre-mRNA-splicing factor BUD31, also known as G10 protein, and its homologues. BUD31 is involved in the pre-mRNA splicing process [1-3] and it is highly conserved in a wide range of eukaryotic species. Human BUD31 may play a role as a regulator of androgen receptor (AR) transcriptional activity, probably increasing the AR transcriptional activity [4].	Domain
R [auth 1]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
S [auth L]	PF13921	Myb-like DNA-binding domain (Myb_DNA-bind_6)	Myb-like DNA-binding domain	This family contains the DNA binding domains from Myb proteins, as well as the SANT domain family [1].	Domain
T [auth N]	PF12171	Zinc-finger double-stranded RNA-binding (zf-C2H2_jaz)	Zinc-finger double-stranded RNA-binding	-	Family
U [auth S]	PF08216	Catenin-beta-like, Arm-motif containing nuclear (CTNNBL)	Catenin-beta-like, Arm-motif containing nuclear	-	Repeat
V [auth r]	PF00679	Elongation factor G C-terminus (EFG_C)	Elongation factor G C-terminus	This domain includes the carboxyl terminal regions of Elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopt a ferredoxin-like fold.	Domain
V [auth r]	PF00009	Elongation factor Tu GTP binding domain (GTP_EFTU)	Elongation factor Tu GTP binding domain	This domain contains a P-loop motif, also found in several other families such as Pfam:PF00071, Pfam:PF00025 and Pfam:PF00063. Elongation factor Tu consists of three structural domains, this plus two C-terminal beta barrel domains.	Domain
V [auth r]	PF14492	Elongation Factor G, domain III (EFG_III)	Elongation Factor G, domain III	This domain is found in Elongation Factor G. It shares a similar structure with domain V (Pfam:PF00679). Structural studies in drosophila indicate this is domain 3 [1].	Domain
V [auth r]	PF16004	116 kDa U5 small nuclear ribonucleoprotein component N-terminus (EFTUD2)	116 kDa U5 small nuclear ribonucleoprotein component N-terminus	-	Family
V [auth r]	PF03144	Elongation factor Tu domain 2 (GTP_EFTU_D2)	Elongation factor Tu domain 2	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as e ...	Elongation factor Tu consists of three structural domains, this is the second domain. This domain adopts a beta barrel structure. This the second domain is involved in binding to charged tRNA [1]. This domain is also found in other proteins such as elongation factor G and translation initiation factor IF-2. This domain is structurally related to Pfam:PF03143, and in fact has weak sequence matches to this domain.	Domain
V [auth r]	PF03764	Elongation factor G, domain IV (EFG_IV)	Elongation factor G, domain IV	This domain is found in elongation factor G, elongation factor 2 and some tetracycline resistance proteins and adopts a ribosomal protein S5 domain 2-like fold.	Domain
W [auth R]	PF04889	Cwf15/Cwc15 cell cycle control protein (Cwf_Cwc_15)	Cwf15/Cwc15 cell cycle control protein	-	Family
X [auth Y]	PF01480	PWI domain (PWI)	PWI domain	-	Family
Y [auth 7]	PF18131	KN17 SH3-like C-terminal domain (KN17_SH3)	KN17 SH3-like C-terminal domain	This domain can be found at the C terminus of the human KIN17 protein and its homologues. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response t ...	This domain can be found at the C terminus of the human KIN17 protein and its homologues. In human cells, over-expression of KIN17 modifies the nuclear morphology and inhibits S-phase progression, thus blocking cell growth as part of the response to genotoxics. The C-terminal domain exhibits an all-beta structure consisting of two tightly packed SH3-like subdomains. It binds to RNA and is generally well conserved. This domain has structural similarity with various SH3-like domains, although it lacks similarities in both primary sequence and charge distribution [1].	Domain
Y [auth 7]	PF10357	Domain of Kin17 curved DNA-binding protein (Kin17_mid)	Domain of Kin17 curved DNA-binding protein	-	Family
Z [auth M]	PF13181	Tetratricopeptide repeat (TPR_8)	Tetratricopeptide repeat	-	Repeat
AA [auth K]	PF06991	Microfibril-associated/Pre-mRNA processing (MFAP1)	Microfibril-associated/Pre-mRNA processing	-	Family
BA [auth O]	PF02184	HAT (Half-A-TPR) repeat (HAT)	HAT (Half-A-TPR) repeat	-	Repeat
CA [auth y]	PF03660	PHF5-like protein (PHF5)	PHF5-like protein	-	Family
EA [auth G]	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
FA [auth h], ZA [auth a]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
IA [auth t]	PF00160	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (Pro_isomerase)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond pr ...	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function [1].	Domain
JA [auth m], VA [auth f]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
BB [auth e], LA [auth l]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
MA [auth A]	PF10597	U5-snRNA binding site 2 of PrP8 (U5_2-snRNA_bdg)	U5-snRNA binding site 2 of PrP8	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that ...	The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis [1]. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [2].	Domain
MA [auth A]	PF10598	RNA recognition motif of the spliceosomal PrP8 (RRM_4)	RNA recognition motif of the spliceosomal PrP8	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molec ...	The large RNA-protein complex of the spliceosome catalyses pre-mRNA splicing. One of the most conserved core proteins is PrP8 which occupies a central position in the catalytic core of the spliceosome, and has been implicated in several crucial molecular rearrangements that occur there, and has recently come under the spotlight for its role in the inherited human disease, Retinitis Pigmentosa [1]. The RNA-recognition motif of PrP8 is highly conserved and provides a possible RNA binding centre for the 5-prime SS, BP, or 3-prime SS of pre-mRNA which are known to contact with Prp8. The most conserved regions of an RRM are defined as the RNP1 and RNP2 sequences. Recognition of RNA targets can also be modulated by a number of other factors, most notably the two loops beta1-alpha1, beta2-beta3 and the amino acid residues C-terminal to the RNP2 domain [2].	Domain
MA [auth A]	PF10596	U6-snRNA interacting domain of PrP8 (U6-snRNA_bdg)	U6-snRNA interacting domain of PrP8	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 ...	This domain incorporates the interacting site for the U6-snRNA as part of the U4/U6.U5 tri-snRNPs complex of the spliceosome, and is the prime candidate for the role of cofactor for the spliceosome's RNA core. The essential spliceosomal protein Prp8 interacts with U5 and U6 snRNAs and with specific pre-mRNA sequences that participate in catalysis. This close association with crucial RNA sequences, together with extensive genetic evidence, suggests that Prp8 could directly affect the function of the catalytic core, perhaps acting as a splicing cofactor [1].	Domain
MA [auth A]	PF08082	PRO8NT (NUC069), PrP8 N-terminal domain (PRO8NT)	PRO8NT (NUC069), PrP8 N-terminal domain	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly va ...	The PRO8NT domain is found at the N-terminus of pre-mRNA splicing factors of PRO8 family [1]. The NLS or nuclear localisation signal for these spliceosome proteins begins at the start and runs for 60 residues. N-terminal to this domain is a highly variable proline-rich region [4].	Domain
MA [auth A]	PF08083	PROCN (NUC071) domain (PROCN)	PROCN (NUC071) domain	The PROCN domain is the central domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
MA [auth A]	PF01398	JAB1/Mov34/MPN/PAD-1 ubiquitin protease (JAB)	JAB1/Mov34/MPN/PAD-1 ubiquitin protease	-	Family
MA [auth A]	PF08084	PROCT (NUC072) domain (PROCT)	PROCT (NUC072) domain	The PROCT domain is the C-terminal domain in pre-mRNA splicing factors of PRO8 family [1].	Domain
DB [auth c], PA [auth j]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
RA [auth n], XA [auth g]	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain
SA [auth P]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
UA [auth p]	PF01805	Surp module (Surp)	Surp module	-	Family
WA [auth F]	PF12874	Zinc-finger of C2H2 type (zf-met)	Zinc-finger of C2H2 type	This is a zinc-finger domain with the CxxCx(12)Hx(6)H motif, found in multiple copies in a wide range of proteins from plants to metazoans. Some member proteins, particularly those from plants, are annotated as being RNA-binding.	Domain
YA [auth 4]	PF16837	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 (SF3A3)	Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp2 ...	SF3A3 is one of the components of the SF3a splicing factor complex of the mature U2 snRNP (small nuclear ribonucleoprotein particle). In yeast, SF3a shows a bifurcated assembly structure of three subunits, Prp9 (subunit 3), Prp11 (subunit 2) and Prp21 (subunit 1). Prp9 and Prp21 were not thought to interact with each other but the alpha1 helix of Prp9 does make important contacts with the SURP2 domain of Prp21, thus the two do interact via a bidentate-binding mode. Prp9 harbours a major binding site for stem-loop IIa of U2 snRNA [1].	Domain
YA [auth 4]	PF13297	Replication stress response SDE2 C-terminal (SDE2_2C)	Replication stress response SDE2 C-terminal	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved fr ...	This domain represents the C-terminal region of the Replication stress response SDE2, a genome surveillance factor. It contains the DNA-binding SAP domain, frequently found in proteins involved in DNA repair. SDE2 C-terminal domain must be cleaved from its N-terminal at a diglycine motif within the ubiquitin-like fold, after Proliferating cell nuclear antigen (PCNA) interaction. This generates a functional protein that negatively regulates damage-inducible PCNA monoubiquitination, which then is proteolytically degraded to allow S phase progression and replication fork recovery in response to DNA damage [1].	Domain
YA [auth 4]	PF12108	Splicing factor SF3a60 binding domain (SF3a60_bindingd)	Splicing factor SF3a60 binding domain	This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is th ...	This domain is found in eukaryotes. This domain is about 30 amino acids in length. This domain has a single completely conserved residue Y that may be functionally important. SF3a60 makes up the SF3a complex with SF3a66 and SF3a120. This domain is the binding site of SF3a60 for SF3a120. The SF3a complex is part of the spliceosome, a protein complex involved in splicing mRNA after transcription.	Domain
GA [auth o]	PF00160	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD (Pro_isomerase)	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond pr ...	The peptidyl-prolyl cis-trans isomerases, also known as cyclophilins, share this domain of about 109 amino acids. Cyclophilins have been found in all organisms studied so far and catalyse peptidyl-prolyl isomerisation during which the peptide bond preceding proline (the peptidyl-prolyl bond) is stabilised in the cis conformation. Mammalian cyclophilin A (CypA) is a major cellular target for the immunosuppressive drug cyclosporin A (CsA). Other roles for cyclophilins may include chaperone and cell signalling function [1].	Domain
GA [auth o]	PF00076	RNA recognition motif (RRM_1)	RNA recognition motif	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and pro ...	The RRM motif (a.k.a. RRM, RBD, or RNP domain) is probably diagnostic of an RNA binding protein. RRMs are found in a variety of RNA binding proteins, including various hnRNP proteins, proteins implicated in regulation of alternative splicing, and protein components of snRNPs. The motif also appears in a few single stranded DNA binding proteins. The RRM structure consists of four strands and two helices arranged in an alpha/beta sandwich, with a third helix present during RNA binding in some cases The C-terminal beta strand (4th strand) and final helix are hard to align and have been omitted in the SEED alignment The LA proteins (Swiss:P05455) have an N terminal rrm which is included in the seed. There is a second region towards the C terminus that has some features characteristic of a rrm but does not appear to have the important structural core of a rrm. The LA proteins (Swiss:P05455) are one of the main autoantigens in Systemic lupus erythematosus (SLE), an autoimmune disease.	Domain
QA [auth I]	PF03371	PRP38 family (PRP38)	PRP38 family	-	Family
CB [auth T]	PF04037	Domain of unknown function (DUF382) (DUF382)	Domain of unknown function (DUF382)	-	Family
CB [auth T]	PF04046	PSP (PSP)	PSP	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	U5 small nuclear ribonucleoprotein 40 kDa protein	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol sno(s)RNA-containing ribonucleoprotein complex U5 snRNP spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
B [auth E]	Splicing factor 3B subunit 3	protein-containing complex binding binding RNA binding snRNA binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly catabolic process negative regulation of biological process macromolecule catabolic process negative regulation of protein catabolic process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process organonitrogen compound catabolic process negative regulation of catabolic process organonitrogen compound metabolic process regulation of protein metabolic process negative regulation of metabolic process protein catabolic process regulation of catabolic process organic substance catabolic process regulation of protein catabolic process cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex nucleoplasm
C [auth b], HA [auth i]	Small nuclear ribonucleoprotein F	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
D [auth W]	U2 small nuclear ribonucleoprotein A'	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U2 snRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen Sm-like protein family complex small nuclear ribonucleoprotein complex spliceosomal snRNP complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
E [auth w]	Splicing factor 3B subunit 4	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly regulation of cellular process regulation of mRNA splicing, via spliceosome positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process positive regulation of mRNA metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of mRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process positive regulation of mRNA splicing, via spliceosome positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of biosynthetic process regulation of mRNA processing biological regulation regulation of macromolecule metabolic process regulation of RNA splicing regulation of cellular biosynthetic process positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing positive regulation of cellular biosynthetic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
F [auth d], NA [auth k]	Small nuclear ribonucleoprotein G	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex P granule cytoplasmic ribonucleoprotein granule germ plasm ribonucleoprotein granule pole plasm intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
G [auth U]	Intron-binding protein aquarius	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding RNA binding nucleic acid binding mRNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity single-stranded RNA binding catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity 3'-5' RNA helicase activity RNA helicase activity ATP-dependent activity, acting on RNA	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
H [auth x]	Splicing factor 3B subunit 5	splicing factor binding protein binding binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly cellular response to stimulus response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process regulation of RNA splicing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic complex peptidase complex protein-DNA complex chromatin chromosome transferase complex histone acetyltransferase complex acetyltransferase complex intracellular non-membrane-bounded organelle protein acetyltransferase complex SAGA-type complex SAGA complex intracellular protein-containing complex non-membrane-bounded organelle precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
I [auth 6]	U6 snRNA	-	-	-
J [auth B]	U2 small nuclear ribonucleoprotein B''	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cytoplasmic ribonucleoprotein granule cellular anatomical entity cytoplasm supramolecular complex non-membrane-bounded organelle ribonucleoprotein granule membrane-bounded organelle U2-type spliceosomal complex protein-containing complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle spliceosomal complex ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome nucleolus fibrillar center U1 snRNP U2-type catalytic step 2 spliceosome
K [auth z]	Splicing factor 3B subunit 6	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process developmental process multicellular organismal process chordate embryonic development embryo development in utero embryonic development multicellular organism development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure development anatomical structure formation involved in morphogenesis blastocyst development RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U12-type spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
L [auth q]	Ubiquitin-like protein 5	protein tag activity molecular tag activity	organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing organic substance metabolic process organonitrogen compound metabolic process macromolecule modification metabolic process primary metabolic process protein metabolic process macromolecule metabolic process protein modification process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing protein localization regulation of localization establishment of protein localization cellular localization regulation of cellular process regulation of protein localization protein targeting regulation of protein targeting to mitochondrion positive regulation of biological process positive regulation of establishment of protein localization localization cellular macromolecule localization positive regulation of protein targeting to mitochondrion positive regulation of cellular process regulation of biological process regulation of establishment of protein localization biological regulation establishment of localization regulation of establishment of protein localization to mitochondrion establishment of protein localization to organelle regulation of protein targeting regulation of cellular localization macromolecule localization protein localization to organelle protein localization to mitochondrion positive regulation of protein localization protein targeting to mitochondrion establishment of protein localization to mitochondrion positive regulation of establishment of protein localization to mitochondrion	membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle Cajal body intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm
M [auth s]	U5 small nuclear ribonucleoprotein 200 kDa helicase	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA RNA helicase activity ATP-dependent activity, acting on RNA identical protein binding protein binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA cis splicing, via spliceosome cis assembly of pre-catalytic spliceosome	membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle membrane cellular anatomical entity membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP
N [auth v]	SNW domain-containing protein 1	protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear vitamin D receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein binding binding signaling receptor binding Notch binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding DNA-binding transcription factor binding nuclear vitamin D receptor binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity nuclear retinoic acid receptor binding RNA binding organic cyclic compound binding nucleic acid binding nuclear androgen receptor binding transcription corepressor activity SMAD binding enzyme binding	regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process regulation of cellular process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of DNA-templated transcription regulation of biological process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular biosynthetic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process negative regulation of cellular process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process negative regulation of biosynthetic process cellular process cellular response to stimulus regulation of signaling intracellular receptor signaling pathway response to stimulus signaling regulation of retinoic acid receptor signaling pathway regulation of signal transduction retinoic acid receptor signaling pathway cell communication regulation of response to stimulus regulation of cell communication signal transduction regulation of vitamin D receptor signaling pathway response to nutrient levels response to organic substance regulation of response to nutrient levels response to lipid response to vitamin cellular response to vitamin D response to vitamin D cellular response to organic substance response to organic cyclic compound response to nutrient cellular response to organic cyclic compound response to oxygen-containing compound cellular response to oxygen-containing compound vitamin D receptor signaling pathway cellular response to nutrient levels cellular response to chemical stimulus cellular response to vitamin response to chemical cellular response to lipid cellular response to nutrient positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway positive regulation of signal transduction cellular response to growth factor stimulus cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of biological process regulation of transforming growth factor beta receptor signaling pathway positive regulation of response to stimulus cellular response to endogenous stimulus enzyme-linked receptor protein signaling pathway positive regulation of cellular process cell surface receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus positive regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to growth factor stimulus positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway positive regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway positive regulation of signaling response to retinoic acid cellular response to retinoic acid positive regulation of vitamin D receptor signaling pathway viral gene expression biological process involved in interspecies interaction between organisms modulation by host of symbiont process viral process biological process involved in interaction with symbiont viral transcription positive regulation by host of viral transcription biological process involved in symbiotic interaction RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing positive regulation of nervous system development multicellular organismal process regulation of developmental process cellular developmental process cell development regulation of cell differentiation regulation of neurogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process multicellular organism development neurogenesis positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of neurogenesis regulation of multicellular organismal process system development developmental process regulation of multicellular organismal development positive regulation of cell development nervous system development positive regulation of multicellular organismal process signal transduction by p53 class mediator cell death intracellular signal transduction intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator apoptotic signaling pathway cellular response to stress DNA damage response response to stress intrinsic apoptotic signaling pathway by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage apoptotic process intrinsic apoptotic signaling pathway programmed cell death transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of mRNA splicing, via spliceosome positive regulation of mRNA metabolic process positive regulation of mRNA processing positive regulation of mRNA splicing, via spliceosome regulation of mRNA processing regulation of RNA splicing positive regulation of gene expression regulation of mRNA metabolic process positive regulation of RNA splicing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck nuclear body nucleoplasm catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
O [auth 3]	BUD13 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex RES complex spliceosomal snRNP complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex RES complex spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome
P [auth 0]	Smad nuclear-interacting protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding molecular function inhibitor activity molecular function regulator activity transcription regulator inhibitor activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular response to stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process negative regulation of canonical NF-kappaB signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette negative regulation of cellular process signal transduction regulation of biological process regulation of signaling negative regulation of response to stimulus biological regulation negative regulation of signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly negative regulation of cellular metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of cellular biosynthetic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process miRNA processing regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Q	Protein BUD31 homolog	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding nuclear receptor binding protein binding binding DNA-binding transcription factor binding transcription coactivator activity transcription regulator activity transcription coregulator activity nuclear receptor coactivator activity protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus regulation of cellular process response to stimulus regulation of signal transduction cell communication regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process signal transduction regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II cellular response to stimulus regulation of cellular process response to stimulus regulation of signal transduction cell communication regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II organic substance biosynthetic process signal transduction regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II regulation of biological process positive regulation of signaling receptor activity cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of molecular function organic cyclic compound metabolic process regulation of gene expression biosynthetic process regulation of response to stimulus regulation of DNA-binding transcription factor activity organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process positive regulation of androgen receptor activity positive regulation of DNA-binding transcription factor activity signaling cellular biosynthetic process regulation of signaling receptor activity RNA metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process organic substance metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of signaling biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of cell communication cellular process RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex protein-DNA complex intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle U2-type spliceosomal complex catalytic step 2 spliceosome catalytic complex nuclear protein-containing complex U2-type catalytic step 2 spliceosome spliceosomal complex ribonucleoprotein complex
R [auth 1]	RNA-binding motif protein, X-linked 2	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome nucleoplasm endoplasmic reticulum cytoplasm
S [auth L]	Cell division cycle 5-like protein	RNA binding binding organic cyclic compound binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity RNA binding binding organic cyclic compound binding nucleic acid binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity WD40-repeat domain binding protein binding protein domain specific binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding	cellular process cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process cellular process cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing regulation of cellular process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process positive regulation of biosynthetic process positive regulation of cellular process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling signal transduction in response to DNA damage	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex cytoplasm U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
T [auth N]	Zinc finger matrin-type protein 2	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex organelle membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome spliceosomal complex precatalytic spliceosome
U [auth S]	Beta-catenin-like protein 1	protein binding binding enzyme binding	response to stimulus immune response immune system process adaptive immune response RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process response to stimulus immune response immune system process adaptive immune response RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of biological process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process apoptotic process programmed cell death positive regulation of cellular process immune system development developmental process production of molecular mediator of immune response multicellular organismal process immunoglobulin production somatic diversification of immunoglobulins multicellular organism development anatomical structure development somatic diversification of immune receptors system development	membrane cellular anatomical entity intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex Prp19 complex membrane-bounded organelle membrane cellular anatomical entity intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex Prp19 complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle spliceosomal complex ribonucleoprotein complex cytoplasm cytosol membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
V [auth r]	116 kDa U5 small nuclear ribonucleoprotein component	RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding RNA binding binding organic cyclic compound binding nucleic acid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding snRNA binding U5 snRNA binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus response to organic substance response to organonitrogen compound response to oxygen-containing compound response to nitrogen compound response to organic cyclic compound response to cocaine response to alkaloid	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex Cajal body U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U2-type catalytic step 2 spliceosome
W [auth R]	Spliceosome-associated protein CWC15 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome Prp19 complex
X [auth Y]	Serine/arginine repetitive matrix protein 1	DNA binding binding organic cyclic compound binding nucleic acid binding RNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process regulation of cellular process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process regulation of mRNA processing regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing mRNA metabolic process regulation of cellular biosynthetic process regulation of gene expression RNA splicing, via transesterification reactions mRNA splicing, via spliceosome regulation of macromolecule biosynthetic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile regulation of mRNA metabolic process regulation of metabolic process localization	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix nuclear speck nuclear body nucleoplasm catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol
Y [auth 7]	DNA/RNA-binding protein KIN17	DNA binding binding organic cyclic compound binding nucleic acid binding double-stranded DNA binding RNA binding cation binding ion binding metal ion binding small molecule binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA repair cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process biosynthetic process organic substance biosynthetic process RNA processing DNA recombination	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoplasm membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoplasm nucleoplasm protein-containing complex
Z [auth M]	Pre-mRNA-splicing factor SYF1	-	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing generation of catalytic spliceosome for first transesterification step protein-containing complex organization cellular metabolic process spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development blastocyst development cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair nucleobase-containing compound biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process organic cyclic compound biosynthetic process	membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane cellular anatomical entity membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex Prp19 complex post-mRNA release spliceosomal complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
AA [auth K]	Microfibrillar-associated protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cell periphery extracellular matrix membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex cell periphery extracellular matrix external encapsulating structure microfibril supramolecular fiber supramolecular polymer supramolecular complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome centrosome microtubule organizing center cytoskeleton intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
BA [auth O]	Crooked neck-like protein 1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex post-mRNA release spliceosomal complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
CA [auth y]	PHD finger-like domain-containing protein 5A	DNA binding binding organic cyclic compound binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding RNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly developmental process stem cell differentiation cellular developmental process cell differentiation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix U2-type spliceosomal complex protein-containing complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex precatalytic spliceosome nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP U2-type precatalytic spliceosome U12-type spliceosomal complex
DA [auth 2]	U2 snRNA	-	-	-
EA [auth G]	Pleiotropic regulator 1	-	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing regulation of cell cycle phase transition regulation of cellular process positive regulation of biological process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of biological process regulation of cell cycle process biological regulation positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to nucleus	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex Prp19 complex nucleolus fibrillar center intracellular non-membrane-bounded organelle non-membrane-bounded organelle U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
FA [auth h], ZA [auth a]	Small nuclear ribonucleoprotein Sm D2	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U2-type catalytic step 2 spliceosome
IA [auth t]	RING-type E3 ubiquitin-protein ligase PPIL2	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-ubiquitin ligase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process organonitrogen compound metabolic process protein polyubiquitination protein ubiquitination macromolecule modification protein metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal protein maturation protein folding protein localization localization protein localization to cell periphery cellular localization protein localization to plasma membrane cellular macromolecule localization macromolecule localization localization within membrane protein localization to membrane mRNA processing mRNA metabolic process	membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm catalytic step 2 spliceosome membrane-bounded organelle intracellular anatomical structure Golgi apparatus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen Golgi lumen intracellular organelle organelle lumen organelle cytoplasm catalytic step 2 spliceosome protein-containing complex catalytic complex nucleus nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cell periphery plasma membrane membrane nucleoplasm nuclear lumen
JA [auth m], VA [auth f]	Small nuclear ribonucleoprotein-associated proteins B and B'	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding U1 snRNP binding ribonucleoprotein complex binding snRNP binding protein-containing complex binding telomerase RNA binding U2 snRNP binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome spliceosomal complex histone pre-mRNA 3'end processing complex cytoplasm cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP prespliceosome U2-type prespliceosome U2-type catalytic step 2 spliceosome
KA [auth Z]	MINX M3 pre-mRNA	-	-	-
BB [auth e], LA [auth l]	Small nuclear ribonucleoprotein Sm D3	RNA binding binding organic cyclic compound binding nucleic acid binding histone pre-mRNA DCP binding snRNA binding U7 snRNA binding telomerase RNA binding protein binding enzyme binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation organonitrogen compound metabolic process protein methylation protein alkylation protein metabolic process protein modification process	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP commitment complex nuclear body U2-type catalytic step 2 spliceosome
MA [auth A]	Pre-mRNA-processing-splicing factor 8	RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding RNA binding snRNA binding binding organic cyclic compound binding nucleic acid binding U1 snRNA binding U6 snRNA binding polyubiquitin modification-dependent protein binding protein binding modification-dependent protein binding K63-linked polyubiquitin modification-dependent protein binding U5 snRNA binding U2 snRNA binding pre-mRNA binding pre-mRNA intronic binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process RNA splicing, via transesterification reactions biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process ribonucleoprotein complex biogenesis mRNA processing spliceosomal tri-snRNP complex assembly protein-RNA complex assembly cellular component organization cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization spliceosomal snRNP assembly mRNA metabolic process mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile cellular response to stimulus response to organic substance biological process involved in interspecies interaction between organisms response to stimulus response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus cellular response to chemical stimulus response to chemical response to bacterium cellular response to lipid cellular response to organic substance response to external biotic stimulus response to molecule of bacterial origin response to cytokine cellular response to tumor necrosis factor cellular response to cytokine stimulus response to tumor necrosis factor	membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP U2-type catalytic step 2 spliceosome
OA [auth 8]	Pre-mRNA-processing factor 17	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing developmental process multicellular organism development multicellular organismal process embryonic brain development anatomical structure development animal organ development embryonic organ development embryo development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
DB [auth c], PA [auth j]	Small nuclear ribonucleoprotein E	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome catalytic complex telomerase holoenzyme complex U2 snRNP catalytic step 2 spliceosome cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP U7 snRNP U2-type catalytic step 2 spliceosome
RA [auth n], XA [auth g]	Small nuclear ribonucleoprotein Sm D1	RNA binding binding organic cyclic compound binding nucleic acid binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal snRNP assembly RNA capping 7-methylguanosine cap hypermethylation macromolecule methylation RNA modification methylation macromolecule modification RNA 5'-end processing RNA methylation	membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex membrane-bounded organelle spliceosomal snRNP complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex Sm-like protein family complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle U4 snRNP small nuclear ribonucleoprotein complex organelle ribonucleoprotein complex pICln-Sm protein complex cytoplasm spliceosomal complex precatalytic spliceosome U2 snRNP catalytic step 2 spliceosome catalytic complex cytosol U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex U1 snRNP membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen SMN-Sm protein complex U2-type spliceosomal complex U2-type precatalytic spliceosome methylosome methyltransferase complex transferase complex U12-type spliceosomal complex U5 snRNP commitment complex U2-type catalytic step 2 spliceosome
SA [auth P]	Pre-mRNA-splicing factor RBM22	pre-mRNA binding RNA binding binding organic cyclic compound binding nucleic acid binding U6 snRNA binding snRNA binding calcium-dependent protein binding protein binding cation binding ion binding metal ion binding small molecule binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process protein localization regulation of localization establishment of protein localization regulation of cellular process nitrogen compound transport nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization localization import into nucleus cellular macromolecule localization establishment of localization in cell regulation of intracellular transport regulation of biological process positive regulation of protein localization to nucleus organic substance transport positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus establishment of localization establishment of protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport cellular localization regulation of protein localization transport positive regulation of nucleocytoplasmic transport positive regulation of biological process regulation of protein localization to nucleus positive regulation of protein transport regulation of protein import into nucleus protein import into nucleus positive regulation of intracellular transport positive regulation of cellular process regulation of transport biological regulation regulation of establishment of protein localization regulation of protein transport positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process regulation of RNA metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biosynthetic process positive regulation of nucleobase-containing compound metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process regulation of RNA splicing positive regulation of RNA metabolic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of RNA splicing regulation of metabolic process positive regulation of cellular biosynthetic process nuclear export regulation of protein export from nucleus protein export from nucleus positive regulation of protein export from nucleus cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome Prp19 complex cytoplasm membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type catalytic step 2 spliceosome
TA [auth 5]	U5 snRNA	-	-	-
UA [auth p]	Splicing factor 3A subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding	cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process cellular biosynthetic process RNA metabolic process mRNA processing nucleobase-containing compound metabolic process organic substance metabolic process organic substance biosynthetic process RNA processing RNA splicing cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA cis splicing, via spliceosome mRNA splicing, via spliceosome metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
WA [auth F]	Splicing factor 3A subunit 2	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development regulation of neuron projection development multicellular organismal process regulation of cellular component organization regulation of cellular process positive regulation of cellular component organization cellular developmental process cell projection organization positive regulation of biological process cell development neuron projection development cellular component organization neurogenesis multicellular organism development neuron differentiation positive regulation of neuron projection development cell differentiation anatomical structure development positive regulation of cell projection organization cellular component organization or biogenesis positive regulation of cellular process system development developmental process regulation of biological process plasma membrane bounded cell projection organization regulation of cell projection organization biological regulation nervous system development generation of neurons neuron development cellular process regulation of plasma membrane bounded cell projection organization ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome prespliceosome U2-type prespliceosome
YA [auth 4]	Splicing factor 3A subunit 3	cation binding transition metal ion binding zinc ion binding ion binding binding metal ion binding small molecule binding RNA binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly mRNA splice site recognition mRNA 3'-splice site recognition	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome precatalytic spliceosome
AB [auth u]	Splicing factor 3B subunit 1	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding splicing factor binding protein binding	ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process ribonucleoprotein complex biogenesis cellular biosynthetic process RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process spliceosomal complex assembly protein-RNA complex organization cellular component assembly organic substance metabolic process protein-containing complex assembly organic substance biosynthetic process cellular component organization or biogenesis RNA processing RNA splicing protein-containing complex organization cellular metabolic process primary metabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions U2-type prespliceosome assembly mRNA splicing, via spliceosome cellular process metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process regulation of cellular process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase I positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological process positive regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase I regulation of cellular metabolic process positive regulation of RNA metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of biosynthetic process positive regulation of transcription by RNA polymerase I positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process biological regulation regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process regulation of transcription by RNA polymerase III positive regulation of transcription by RNA polymerase III transcription by RNA polymerase III transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II protein-DNA complex organization chromatin organization chromatin remodeling	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle nuclear speck nuclear body nucleoplasm spliceosomal snRNP complex protein-containing complex nuclear protein-containing complex Sm-like protein family complex small nuclear ribonucleoprotein complex ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex spliceosomal complex U11/U12 snRNP U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome U12-type spliceosomal complex ATPase complex B-WICH complex chromosome SWI/SNF superfamily-type complex protein-DNA complex chromatin prespliceosome U2-type prespliceosome
GA [auth o]	Peptidyl-prolyl cis-trans isomerase E	isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding amide binding isomerase activity catalytic activity, acting on a protein peptidyl-prolyl cis-trans isomerase activity catalytic activity cis-trans isomerase activity RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding poly(A) binding poly-purine tract binding single-stranded RNA binding amide binding cyclosporin A binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process macromolecule modification peptidyl-amino acid modification peptidyl-proline modification protein modification process protein peptidyl-prolyl isomerization regulation of cellular process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression organic cyclic compound biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of viral genome replication positive regulation of viral process positive regulation of biological process viral life cycle regulation of viral process regulation of viral life cycle viral genome replication viral process regulation of viral genome replication RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen catalytic step 2 spliceosome protein-containing complex catalytic complex nuclear protein-containing complex spliceosomal complex ribonucleoprotein complex cytoplasm cytosol intracellular vesicle ficolin-1-rich granule endomembrane system cytoplasmic vesicle ficolin-1-rich granule lumen secretory granule secretory vesicle vesicle extracellular region vesicle lumen cytoplasmic vesicle lumen secretory granule lumen U2-type spliceosomal complex U2-type catalytic step 2 spliceosome
QA [auth I]	Pre-mRNA-splicing factor 38A	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process metabolic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process RNA processing	membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome
CB [auth T]	Splicing factor 3B subunit 2	RNA binding binding organic cyclic compound binding nucleic acid binding	RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process primary metabolic process gene expression macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process RNA processing macromolecule metabolic process mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile ribonucleoprotein complex biogenesis protein-RNA complex assembly cellular component organization cellular component biogenesis spliceosomal complex assembly protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization U2-type prespliceosome assembly	membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome membrane-enclosed lumen intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen spliceosomal snRNP complex Sm-like protein family complex small nuclear ribonucleoprotein complex U2 snRNP catalytic step 2 spliceosome catalytic complex U2-type precatalytic spliceosome U12-type spliceosomal complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR019775	WD40 repeat, conserved site	Conserved Site
A [auth D]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A [auth D]	IPR001680	WD40 repeat	Repeat
A [auth D]	IPR020472	G-protein beta WD-40 repeat	Repeat
A [auth D]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
B [auth E]	IPR018846	Cleavage/polyadenylation specificity factor, A subunit, N-terminal	Domain
B [auth E]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
B [auth E]	IPR004871	Cleavage/polyadenylation specificity factor, A subunit, C-terminal	Domain
B [auth E]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
C [auth b], HA [auth i]	IPR016487	Sm-like protein Lsm6/SmF	Family
C [auth b], HA [auth i]	IPR034100	Small nuclear ribonucleoprotein F	Family
C [auth b], HA [auth i]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
C [auth b], HA [auth i]	IPR047575	Sm domain	Domain
C [auth b], HA [auth i]	IPR010920	LSM domain superfamily	Homologous Superfamily
D [auth W]	IPR001611	Leucine-rich repeat	Repeat
D [auth W]	IPR003603	U2A'/phosphoprotein 32 family A, C-terminal	Domain
D [auth W]	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
E [auth w]	IPR034159	SF3B4, RNA recognition motif 2	Domain
E [auth w]	IPR000504	RNA recognition motif domain	Domain
E [auth w]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
E [auth w]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
E [auth w]	IPR034158	SF3B4, RNA recognition motif 1	Domain
F [auth d], NA [auth k]	IPR044641	Sm-like protein Lsm7/SmG	Family
F [auth d], NA [auth k]	IPR034098	Small nuclear ribonucleoprotein G	Family
F [auth d], NA [auth k]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
F [auth d], NA [auth k]	IPR047575	Sm domain	Domain
F [auth d], NA [auth k]	IPR010920	LSM domain superfamily	Homologous Superfamily
G [auth U]	IPR048966	RNA helicase aquarius, beta-barrel	Domain
G [auth U]	IPR048967	RNA helicase aquarius, insertion domain	Domain
G [auth U]	IPR041677	DNA2/NAM7 helicase, helicase domain	Domain
G [auth U]	IPR026300	CWF11 family	Family
G [auth U]	IPR045055	DNA2/NAM7-like helicase	Family
G [auth U]	IPR032174	RNA helicase aquarius, N-terminal domain	Domain
G [auth U]	IPR041679	DNA2/NAM7 helicase-like, C-terminal	Domain
G [auth U]	IPR047187	Upf1-like, C-terminal helicase domain	Domain
G [auth U]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
H [auth x]	IPR017089	Splicing factor 3B, subunit 5	Family
H [auth x]	IPR009846	Splicing factor 3B subunit 5/RDS3 complex subunit 10	Family
J [auth B]	IPR034562	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 2	Domain
J [auth B]	IPR000504	RNA recognition motif domain	Domain
J [auth B]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
J [auth B]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
J [auth B]	IPR034564	U2 small nuclear ribonucleoprotein B'', RNA recognition motif 1	Domain
K [auth z]	IPR000504	RNA recognition motif domain	Domain
K [auth z]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
K [auth z]	IPR034150	SF3B6, RNA recognition motif	Domain
K [auth z]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
L [auth q]	IPR039732	Ubiquitin-like modifier Hub1/Ubl5	Family
L [auth q]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
L [auth q]	IPR000626	Ubiquitin-like domain	Domain
M [auth s]	IPR048863	Pre-mRNA-splicing helicase BRR2-like, plug domain	Domain
M [auth s]	IPR041094	Brr2, N-terminal helicase PWI domain	Domain
M [auth s]	IPR004179	Sec63 domain	Domain
M [auth s]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
M [auth s]	IPR011545	DEAD/DEAH box helicase domain	Domain
M [auth s]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
M [auth s]	IPR001650	Helicase, C-terminal domain-like	Domain
M [auth s]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
M [auth s]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
M [auth s]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
M [auth s]	IPR035892	C2 domain superfamily	Homologous Superfamily
N [auth v]	IPR017862	SKI-interacting protein, SKIP	Family
N [auth v]	IPR004015	SKI-interacting protein SKIP, SNW domain	Domain
O [auth 3]	IPR018609	Bud13	Family
P [auth 0]	IPR008984	SMAD/FHA domain superfamily	Homologous Superfamily
P [auth 0]	IPR000253	Forkhead-associated (FHA) domain	Domain
Q	IPR001748	Pre-mRNA-splicing factor BUD31	Family
Q	IPR018230	BUD31/G10-related, conserved site	Conserved Site
R [auth 1]	IPR000504	RNA recognition motif domain	Domain
R [auth 1]	IPR045844	Ist3-like, RNA recognition motif	Domain
R [auth 1]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
R [auth 1]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
S [auth L]	IPR047240	Pre-mRNA splicing factor component CDC5L/Cef1, second SANT/myb-like domain	Domain
S [auth L]	IPR017930	Myb domain	Domain
S [auth L]	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily
S [auth L]	IPR047242	Pre-mRNA splicing factor component CDC5L/Cef1	Family
S [auth L]	IPR001005	SANT/Myb domain	Domain
S [auth L]	IPR021786	Pre-mRNA splicing factor component Cdc5p/Cef1, C-terminal	Domain
T [auth N]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
T [auth N]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
T [auth N]	IPR040107	U4/U6.U5 small nuclear ribonucleoprotein component Snu23	Family
T [auth N]	IPR022755	Zinc finger, double-stranded RNA binding	Domain
U [auth S]	IPR016024	Armadillo-type fold	Homologous Superfamily
U [auth S]	IPR039678	Beta-catenin-like protein 1	Family
U [auth S]	IPR011989	Armadillo-like helical	Homologous Superfamily
U [auth S]	IPR013180	Beta-catenin-like protein 1, N-terminal	Domain
V [auth r]	IPR005517	Translation elongation factor EFG/EF2, domain IV	Domain
V [auth r]	IPR000795	Translational (tr)-type GTP-binding domain	Domain
V [auth r]	IPR035647	EF-G domain III/V-like	Homologous Superfamily
V [auth r]	IPR035655	116kDa U5 small nuclear ribonucleoprotein component, C-terminal	Domain
V [auth r]	IPR041095	Elongation Factor G, domain II	Domain
V [auth r]	IPR004161	Translation elongation factor EFTu-like, domain 2	Domain
V [auth r]	IPR009000	Translation protein, beta-barrel domain superfamily	Homologous Superfamily
V [auth r]	IPR020568	Ribosomal protein uS5 domain 2-type superfamily	Homologous Superfamily
V [auth r]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
V [auth r]	IPR014721	Small ribosomal subunit protein uS5 domain 2-type fold, subgroup	Homologous Superfamily
V [auth r]	IPR031950	116kDa U5 small nuclear ribonucleoprotein component, N-terminal	Domain
V [auth r]	IPR000640	Elongation factor EFG, domain V-like	Domain
V [auth r]	IPR044121	Snu114, GTP-binding domain	Domain
V [auth r]	IPR005225	Small GTP-binding protein domain	Domain
W [auth R]	IPR006973	Pre-mRNA-splicing factor Cwf15/Cwc15	Family
X [auth Y]	IPR002483	PWI domain	Domain
X [auth Y]	IPR036483	PWI domain superfamily	Homologous Superfamily
Y [auth 7]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
Y [auth 7]	IPR019447	DNA/RNA-binding protein Kin17, WH-like domain	Domain
Y [auth 7]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
Y [auth 7]	IPR041995	Kin17, KOW domain	Domain
Y [auth 7]	IPR041330	KN17, SH3-like C-terminal domain	Domain
Y [auth 7]	IPR037321	KIN17-like protein	Family
Y [auth 7]	IPR038254	DNA/RNA-binding protein KIN17, WH-like domain superfamily	Homologous Superfamily
Z [auth M]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
Z [auth M]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
Z [auth M]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
Z [auth M]	IPR019734	Tetratricopeptide repeat	Repeat
AA [auth K]	IPR033194	Microfibrillar-associated protein 1	Family
AA [auth K]	IPR009730	Micro-fibrillar-associated protein 1, C-terminal	Domain
BA [auth O]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
BA [auth O]	IPR003107	HAT (Half-A-TPR) repeat	Repeat
BA [auth O]	IPR045075	Pre-mRNA-splicing factor Syf1-like	Family
CA [auth y]	IPR005345	PHF5-like	Family
EA [auth G]	IPR019775	WD40 repeat, conserved site	Conserved Site
EA [auth G]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
EA [auth G]	IPR045241	WD repeat Prp46/PLRG1-like	Family
EA [auth G]	IPR001680	WD40 repeat	Repeat
EA [auth G]	IPR020472	G-protein beta WD-40 repeat	Repeat
EA [auth G]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
FA [auth h], ZA [auth a]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
FA [auth h], ZA [auth a]	IPR047575	Sm domain	Domain
FA [auth h], ZA [auth a]	IPR027248	Small nuclear ribonucleoprotein Sm D2	Family
FA [auth h], ZA [auth a]	IPR010920	LSM domain superfamily	Homologous Superfamily
IA [auth t]	IPR003613	U-box domain	Domain
IA [auth t]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
IA [auth t]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
IA [auth t]	IPR044666	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like	Family
IA [auth t]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
IA [auth t]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
IA [auth t]	IPR026951	Peptidyl-prolyl cis-trans isomerase like 2, U-box domain	Domain
JA [auth m], VA [auth f]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
JA [auth m], VA [auth f]	IPR017131	Small ribonucleoprotein associated, SmB/SmN	Family
JA [auth m], VA [auth f]	IPR047575	Sm domain	Domain
JA [auth m], VA [auth f]	IPR010920	LSM domain superfamily	Homologous Superfamily
BB [auth e], LA [auth l]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
BB [auth e], LA [auth l]	IPR034099	Small nuclear ribonucleoprotein Sm D3	Family
BB [auth e], LA [auth l]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
BB [auth e], LA [auth l]	IPR047575	Sm domain	Domain
BB [auth e], LA [auth l]	IPR010920	LSM domain superfamily	Homologous Superfamily
MA [auth A]	IPR012984	PROCT domain	Domain
MA [auth A]	IPR012591	PRO8NT domain	Domain
MA [auth A]	IPR019580	Pre-mRNA-processing-splicing factor 8, U6-snRNA-binding	Domain
MA [auth A]	IPR027652	Pre-mRNA-processing-splicing factor 8	Family
MA [auth A]	IPR043172	Prp8 RNase domain IV, palm region	Homologous Superfamily
MA [auth A]	IPR012592	PROCN domain	Domain
MA [auth A]	IPR012337	Ribonuclease H-like superfamily	Homologous Superfamily
MA [auth A]	IPR043173	Prp8 RNase domain IV, fingers region	Homologous Superfamily
MA [auth A]	IPR021983	PRP8 domain IV core	Domain
MA [auth A]	IPR019581	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding	Domain
MA [auth A]	IPR037518	MPN domain	Domain
MA [auth A]	IPR019582	RNA recognition motif, spliceosomal PrP8	Domain
MA [auth A]	IPR042516	Pre-mRNA-processing-splicing factor 8, U5-snRNA-binding domain superfamily	Homologous Superfamily
MA [auth A]	IPR000555	JAB1/MPN/MOV34 metalloenzyme domain	Domain
OA [auth 8]	IPR019775	WD40 repeat, conserved site	Conserved Site
OA [auth 8]	IPR032847	Pre-mRNA-processing factor 17	Family
OA [auth 8]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
OA [auth 8]	IPR001680	WD40 repeat	Repeat
OA [auth 8]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
DB [auth c], PA [auth j]	IPR027078	Small nuclear ribonucleoprotein E	Family
DB [auth c], PA [auth j]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
DB [auth c], PA [auth j]	IPR047575	Sm domain	Domain
DB [auth c], PA [auth j]	IPR010920	LSM domain superfamily	Homologous Superfamily
RA [auth n], XA [auth g]	IPR027141	Like-Sm (LSM) domain containing protein, LSm4/SmD1/SmD3	Family
RA [auth n], XA [auth g]	IPR034102	Small nuclear ribonucleoprotein D1	Domain
RA [auth n], XA [auth g]	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
RA [auth n], XA [auth g]	IPR047575	Sm domain	Domain
RA [auth n], XA [auth g]	IPR010920	LSM domain superfamily	Homologous Superfamily
SA [auth P]	IPR036855	Zinc finger, CCCH-type superfamily	Homologous Superfamily
SA [auth P]	IPR039171	Pre-mRNA-splicing factor Cwc2/Slt11	Family
SA [auth P]	IPR000504	RNA recognition motif domain	Domain
SA [auth P]	IPR000571	Zinc finger, CCCH-type	Domain
SA [auth P]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
SA [auth P]	IPR048995	STL11/RBM22-like, N-terminal domain	Domain
SA [auth P]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
UA [auth p]	IPR045146	Splicing factor 3A subunit 1	Family
UA [auth p]	IPR035967	SWAP/Surp superfamily	Homologous Superfamily
UA [auth p]	IPR000061	SWAP/Surp	Domain
UA [auth p]	IPR000626	Ubiquitin-like domain	Domain
UA [auth p]	IPR035563	Splicing factor 3A subunit 1, ubiquitin domain	Domain
UA [auth p]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
UA [auth p]	IPR022030	Splicing factor 3A subunit 1, conserved domain	Domain
WA [auth F]	IPR031781	SF3A2 domain	Domain
WA [auth F]	IPR003604	Matrin/U1-C-like, C2H2-type zinc finger	Domain
WA [auth F]	IPR013087	Zinc finger C2H2-type	Domain
WA [auth F]	IPR036236	Zinc finger C2H2 superfamily	Homologous Superfamily
WA [auth F]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
YA [auth 4]	IPR021966	Splicing factor SF3a60 binding domain	Domain
YA [auth 4]	IPR031774	SF3A3 domain	Domain
YA [auth 4]	IPR024598	Splicing factor SF3a60 /Prp9 subunit, C-terminal	Domain
YA [auth 4]	IPR000690	Matrin/U1-C, C2H2-type zinc finger	Domain
YA [auth 4]	IPR025086	SDE2-like, C-terminal domain	Domain
AB [auth u]	IPR016024	Armadillo-type fold	Homologous Superfamily
AB [auth u]	IPR011989	Armadillo-like helical	Homologous Superfamily
AB [auth u]	IPR015016	Splicing factor 3B subunit 1	Domain
AB [auth u]	IPR038737	Splicing factor 3B subunit 1-like	Family
GA [auth o]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
GA [auth o]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
GA [auth o]	IPR034168	Peptidyl-prolyl cis-trans isomerase E, RNA recognition motif	Domain
GA [auth o]	IPR016304	Peptidyl-prolyl cis-trans isomerase E	Family
GA [auth o]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
GA [auth o]	IPR000504	RNA recognition motif domain	Domain
GA [auth o]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
GA [auth o]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily
QA [auth I]	IPR024767	Pre-mRNA-splicing factor 38, C-terminal	Domain
QA [auth I]	IPR005037	Pre-mRNA-splicing factor 38	Family
CB [auth T]	IPR006568	PSP, proline-rich	Domain
CB [auth T]	IPR007180	Domain of unknown function DUF382	Domain
CB [auth T]	IPR003034	SAP domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth D]	Pharos: Q96DI7	large cell medulloblastoma medulloblastoma subependymal giant cell astrocytoma lung cancer pituitary cancer malignant mesothelioma primitive neuroectodermal tumor
B [auth E]	Pharos: Q15393	astrocytic tumor Intractable Eczema lung cancer atopic eczema large cell medulloblastoma malignant colon neoplasm atypical teratoid rhabdoid tumor ovarian cancer
C [auth b], HA [auth i]	Pharos: P62306	atypical teratoid rhabdoid tumor glioblastoma malignant ependymoma primitive neuroectodermal tumor chronic obstructive pulmonary disease large cell medulloblastoma malignant glioma squamous cell carcinoma cutaneous melanoma lung cancer medulloblastoma
E [auth w]	Pharos: Q15427	Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis Nager acrofacial dysostosis acrofacial dysostosis Rodriguez type breast carcinoma intellectual disability malignant glioma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm astrocytic tumor glioblastoma large cell medulloblastoma malignant mesothelioma ovarian cancer Radial club hand atypical teratoid rhabdoid tumor idiopathic scoliosis malignant ependymoma pancreatic ductal adenocarcinoma
F [auth d], NA [auth k]	Pharos: P62308	Adenocarcinoma of Lung lung adenocarcinoma
G [auth U]	Pharos: O60306	atypical teratoid rhabdoid tumor hepatocellular carcinoma medulloblastoma psoriasis gastric cancer large cell medulloblastoma oligodendroglioma gastric carcinoma malignant mesothelioma ovarian cancer
H [auth x]	Pharos: Q9BWJ5	diabetes mellitus pancreatic ductal adenocarcinoma glioblastoma Sjogren syndrome ovarian cancer
J [auth B]	Pharos: P08579	breast carcinoma medulloblastoma colorectal cancer lung cancer
K [auth z]	Pharos: Q9Y3B4	breast cancer ovarian cancer endogenous depression medulloblastoma
L [auth q]	Pharos: Q9BZL1	plasma cell myeloma psoriasis
M [auth s]	Pharos: O75643	retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer diabetes mellitus malignant ependymoma oligodendroglioma primitive neuroectodermal tumor
N [auth v]	Pharos: Q13573	lung cancer plasma cell myeloma medulloblastoma psoriasis ovarian cancer
O [auth 3]	Pharos: Q9BRD0	metabolic syndrome X abdominal aortic aneurysm medulloblastoma non-alcoholic fatty liver disease heart disease metabolic disease hypertrophic pyloric stenosis
P [auth 0]	Pharos: Q8TAD8	psychomotor retardation, epilepsy, and craniofacial dysmorphism endometrial carcinoma oligodendroglioma psoriasis epilepsy osteosarcoma intellectual disability ovarian carcinoma tuberculosis
Q	Pharos: P41223	attention deficit hyperactivity disorder, inattentive type plasma cell myeloma glioblastoma ovarian cancer
S [auth L]	Pharos: Q99459	breast cancer ossification of the posterior longitudinal ligament of the spine psoriasis dermatomyositis osteosarcoma lymphoplasmacytic lymphoma plasma cell myeloma
T [auth N]	Pharos: Q96NC0	atypical teratoid rhabdoid tumor ovarian cancer glioblastoma large cell medulloblastoma
U [auth S]	Pharos: Q8WYA6	lung cancer ovarian cancer medulloblastoma osteosarcoma
V [auth r]	Pharos: Q15029	mandibulofacial dysostosis-microcephaly syndrome intellectual disability choanal atresia large cell medulloblastoma Nager acrofacial dysostosis diabetes mellitus ovarian cancer microcephaly Primary microcephaly
W [auth R]	Pharos: Q9P013	ovarian cancer
X [auth Y]	Pharos: Q8IYB3	acute myeloid leukemia pancreatic intraductal papillary-mucinous neoplasm myopathy plasma cell myeloma ovarian cancer
Y [auth 7]	Pharos: O60870	Alzheimer disease ovarian cancer medulloblastoma osteosarcoma
Z [auth M]	Pharos: Q9HCS7	diabetes mellitus osteosarcoma psoriasis
AA [auth K]	Pharos: P55081	metabolic syndrome X ovarian cancer psoriasis
BA [auth O]	Pharos: Q9BZJ0	exocrine pancreatic carcinoma malignant pancreatic neoplasm tuberculosis hepatocellular carcinoma myopathy invasive ductal breast carcinoma ovarian cancer
CA [auth y]	Pharos: Q7RTV0	allergic rhinitis vitiligo Crohn disease osteosarcoma
EA [auth G]	Pharos: O43660	juvenile dermatomyositis vascular disease myopathy ovarian cancer
FA [auth h], ZA [auth a]	Pharos: P62316	chronic obstructive pulmonary disease lung cancer ovarian cancer diabetes mellitus lymphoplasmacytic lymphoma plasma cell myeloma heart disease medulloblastoma
IA [auth t]	Pharos: Q13356	astrocytic tumor hepatitis B virus infection large cell medulloblastoma osteosarcoma psoriasis celiac disease inflammatory bowel disease myositis pancreatic intraductal papillary-mucinous carcinoma systemic lupus erythematosus Crohn disease juvenile idiopathic arthritis oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia systemic sclerosis
JA [auth m], VA [auth f]	Pharos: P14678	cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma cerebrocostomandibular syndrome intellectual disability ovarian cancer atypical teratoid rhabdoid tumor dermatomyositis Disease Progression glioblastoma invasive ductal breast carcinoma malignant glioma medulloblastoma plasma cell myeloma diabetes mellitus gastric cancer hereditary diffuse gastric adenocarcinoma large cell medulloblastoma malignant mesothelioma osteosarcoma psoriasis gastric neoplasm lymphoplasmacytic lymphoma
BB [auth e], LA [auth l]	Pharos: P62318	carcinoma Mammary Neoplasms, Experimental HIV infectious disease sarcomatoid carcinoma acne lymphoplasmacytic lymphoma ovarian cancer undifferentiated carcinoma medulloblastoma plasma cell myeloma dermatomyositis lung cancer mammary neoplasms, animal non-alcoholic fatty liver disease
MA [auth A]	Pharos: Q6P2Q9	retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma retinitis pigmentosa retinitis pigmentosa 13 HIV infectious disease Acute Cerebrovascular Accidents brain aneurysm cone-rod dystrophy malignant ependymoma pancreatic ductal adenocarcinoma acute myeloid leukemia diabetes mellitus oligodendroglioma retinal degeneration astrocytic tumor cerebrovascular disorder glioblastoma Hodgkins lymphoma ovarian cancer
OA [auth 8]	Pharos: O60508	adenoma glioblastoma ovarian cancer atypical teratoid rhabdoid tumor large cell medulloblastoma psoriasis Gaucher disease malignant ependymoma tuberculosis
DB [auth c], PA [auth j]	Pharos: P62304	hypotrichosis hypotrichosis 11 hypotrichosis simplex breast carcinoma
RA [auth n], XA [auth g]	Pharos: P62314	acute myeloid leukemia gastric carcinoma medulloblastoma plasma cell myeloma psoriasis atypical teratoid rhabdoid tumor large cell medulloblastoma non-small cell lung carcinoma pneumonia dermatomyositis lung cancer ovarian cancer polycystic ovary syndrome
SA [auth P]	Pharos: Q9NW64	astrocytic tumor oligodendroglioma plasma cell myeloma malignant mesothelioma osteosarcoma subependymal giant cell astrocytoma medulloblastoma ovarian cancer
UA [auth p]	Pharos: Q15459	astrocytic tumor heart disease oligodendroglioma psoriasis colorectal cancer large cell medulloblastoma osteosarcoma rheumatoid arthritis glioblastoma myopathy ovarian cancer subependymal giant cell astrocytoma
WA [auth F]	Pharos: Q15428	astrocytic tumor glioblastoma medulloblastoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor large cell medulloblastoma myocardial infarction psoriasis Gaucher disease malignant mesothelioma ovarian cancer
YA [auth 4]	Pharos: Q12874	HIV infectious disease astrocytic tumor diabetes mellitus HIV Coinfection ovarian cancer colorectal adenoma Hashimoto thyroiditis colorectal cancer heart disease malignant mesothelioma
AB [auth u]	Pharos: O75533	B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor abdominal aortic aneurysm Prostatic Neoplasms anorexia nervosa thoracic aortic aneurysm autism spectrum disorder brain aneurysm malignant ependymoma B-cell chronic lymphocytic leukemia uveal melanoma myelodysplastic syndrome malignant mesothelioma prostate cancer ocular melanoma ovarian cancer primitive neuroectodermal tumor abdominal aortic aneurysm Prostatic Neoplasms anorexia nervosa thoracic aortic aneurysm autism spectrum disorder brain aneurysm malignant ependymoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma progressive supranuclear palsy acute myeloid leukemia psoriasis astrocytic tumor cancer Gaucher disease large cell medulloblastoma osteosarcoma Pick disease allergic rhinitis atypical teratoid rhabdoid tumor bipolar disorder congenital anemia glioblastoma malignant choroid melanoma
GA [auth o]	Pharos: Q9UNP9	attention deficit hyperactivity disorder, inattentive type chronic obstructive pulmonary disease ovarian cancer
QA [auth I]	Pharos: Q8NAV1	non-small cell lung carcinoma tuberculosis osteosarcoma ovarian cancer
CB [auth T]	Pharos: Q13435	astrocytic tumor ovarian cancer bipolar I disorder plasma cell myeloma obesity disorder