Annotations: 7AAH

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF11938	e7aahA1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: PF11938	ECOD (1.6)
B	PF11938	e7aahB1	A: alpha arrays	X: Saposin-like	H: Saposin-like (From Topology)	T: Saposin-like	F: PF11938	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF11938	TLR4 regulator and MIR-interacting MSAP (DUF3456)	TLR4 regulator and MIR-interacting MSAP	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Marginal zone B- and B1-cell-specific protein	-	regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process apoptotic process cell death programmed cell death regulation of immune effector process immunoglobulin production regulation of biological process cell population proliferation regulation of cellular process positive regulation of cell population proliferation regulation of cell population proliferation biological regulation positive regulation of biological process cellular process positive regulation of cellular process apoptotic process cell death programmed cell death regulation of immune effector process immunoglobulin production cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of immune effector process regulation of immune system process positive regulation of macromolecule metabolic process positive regulation of immune system process positive regulation of immunoglobulin production regulation of biosynthetic process production of molecular mediator of immune response cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process immune effector process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of immunoglobulin production positive regulation of gene expression immune system process positive regulation of production of molecular mediator of immune response regulation of macromolecule biosynthetic process metabolic process regulation of production of molecular mediator of immune response macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly integrin activation cellular component organization or biogenesis multicellular organismal process regulation of leukocyte activation regulation of cell activation lymphocyte activation leukocyte proliferation leukocyte activation regulation of B cell proliferation lymphocyte proliferation regulation of B cell activation regulation of multicellular organismal process regulation of lymphocyte proliferation regulation of leukocyte proliferation B cell activation cell activation B cell proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular response to stimulus cellular response to nitrogen compound response to organic substance response to stimulus signaling response to peptide hormone regulation of signal transduction insulin receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway cell communication cellular response to endogenous stimulus response to hormone cellular response to organic substance signal transduction enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus regulation of signaling cell surface receptor signaling pathway regulation of insulin receptor signaling pathway response to endogenous stimulus response to organonitrogen compound response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus cellular response to organonitrogen compound regulation of response to stimulus response to chemical response to insulin regulation of cell communication cellular response to insulin stimulus	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum extracellular region intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum extracellular region protein-containing complex endoplasmic reticulum chaperone complex endoplasmic reticulum protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR021852	Domain of unknown function DUF3456	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q8WU39	chronic obstructive pulmonary disease exocrine pancreatic carcinoma malignant pancreatic neoplasm sinusitis cystic fibrosis interstitial cystitis osteosarcoma tuberculosis esophageal squamous cell carcinoma lung adenocarcinoma periodontitis ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.