Annotations: 6ZO4

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth G]	PF00022	e6zo4G1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
E [auth I]	PF00022	e6zo4I1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
D [auth H]	PF00022	e6zo4H1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
F [auth J]	PF00022	e6zo4J2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
H [auth U]	F_UNCLASSIFIED	e6zo4U1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth V]	PF21711	e6zo4V1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF21711	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth G], E [auth I]	PF00022	Actin (Actin)	Actin	-	Family
D [auth H]	PF00022	Actin (Actin)	Actin	-	Family
F [auth J]	PF00022	Actin (Actin)	Actin	-	Family
G [auth M]	PF04912	Dynamitin (Dynamitin)	Dynamitin	-	Family
I [auth V]	PF21711	Dynactin subunit 5 (DCTN5)	Dynactin subunit 5	-	Repeat
J [auth Y]	PF05502	Dynactin p62 family (Dynactin_p62)	Dynactin p62 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 5], B [auth 6]	BICD2	-	-	-
C [auth G], E [auth I]	ARP1 actin related protein 1 homolog A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	-	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
D [auth H]	Actin, cytoplasmic 1	hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nitric-oxide synthase binding protein binding enzyme binding identical protein binding cytoskeletal protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding	cellular response to stimulus cellular response to nitrogen compound response to cytochalasin B response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to stimulus cellular response to nitrogen compound response to cytochalasin B response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process cellular response to organic substance response to organic cyclic compound regulation of localization import into cell cellular localization regulation of cellular process regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of biological process regulation of transport biological regulation regulation of vesicle-mediated transport establishment of localization endocytosis multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process organic substance metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination positive regulation of cellular process DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic substance transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane cell motility adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction organization cell-cell junction assembly transepithelial transport regulation of transepithelial transport apical protein localization protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction cell cycle regulation of cell cycle	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cluster of actin-based cell projections brush border synapse cell junction glutamatergic synapse apical junction complex cell-cell junction anchoring junction adherens junction axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton protein-containing complex catalytic complex protein-DNA complex NuA4 histone acetyltransferase complex chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex dense body plasma membrane nucleosome cytoplasmic ribonucleoprotein granule ribonucleoprotein granule Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle
F [auth J]	Arp11	-	establishment of organelle localization cellular localization organelle transport along microtubule transport localization mitochondrion localization mitochondrion transport along microtubule organelle localization establishment of localization in cell transport along microtubule axonal transport of mitochondrion establishment of mitochondrion localization retrograde axonal transport intracellular transport establishment of organelle localization cellular localization organelle transport along microtubule transport localization mitochondrion localization mitochondrion transport along microtubule organelle localization establishment of localization in cell transport along microtubule axonal transport of mitochondrion establishment of mitochondrion localization retrograde axonal transport intracellular transport axonal transport establishment of localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport microtubule-based transport cytoskeleton-dependent intracellular transport cellular process microtubule-based movement microtubule-based process retrograde axonal transport of mitochondrion	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle neuron projection cytoplasm axon protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cytoplasm
G [auth M]	Dynactin subunit 2	-	microtubule-based process cellular process	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle membrane cytoplasm protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle membrane cytoplasm catalytic complex dynein complex centrosome microtubule organizing center polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
H [auth U]	Dynactin 6	protein-containing complex binding binding dynein complex binding	microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process cellular process microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm centrosome microtubule organizing center
I [auth V]	Dynactin subunit 5	-	developmental process heart development multicellular organismal process animal organ development ventricular septum development circulatory system development multicellular organism development cardiac septum development cardiac chamber development anatomical structure development cardiac ventricle development system development coronary vasculature development vasculature development developmental process heart development multicellular organismal process animal organ development ventricular septum development circulatory system development multicellular organism development cardiac septum development cardiac chamber development anatomical structure development cardiac ventricle development system development coronary vasculature development vasculature development blood vessel development artery development aorta development	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm membrane-bounded organelle nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen centrosome microtubule organizing center
J [auth Y]	Dynactin subunit 4	-	-	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle sarcomere contractile muscle fiber protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle sarcomere contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell periphery cell cortex centrosome microtubule organizing center actin filament bundle actomyosin stress fiber contractile actin filament bundle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth G], E [auth I]	IPR020902	Actin/actin-like conserved site	Conserved Site
C [auth G], E [auth I]	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
C [auth G], E [auth I]	IPR004000	Actin family	Family
D [auth H]	IPR020902	Actin/actin-like conserved site	Conserved Site
D [auth H]	IPR004001	Actin, conserved site	Conserved Site
D [auth H]	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
D [auth H]	IPR004000	Actin family	Family
F [auth J]	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
F [auth J]	IPR004000	Actin family	Family
G [auth M]	IPR028133	Dynamitin	Family
H [auth U]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
H [auth U]	IPR027777	Dynactin subunit 6	Family
I [auth V]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
I [auth V]	IPR047125	Dynactin subunit 5	Family
J [auth Y]	IPR008603	Dynactin subunit 4	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.