Annotations: 6ZNL

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
K	SCOP2B Superfamily	Subunits of heterodimeric actin filament capping protein Capz	8077311	3001499	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00022	e6znlA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
B	PF00022	e6znlB2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
C	PF00022	e6znlC1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
D	PF00022	e6znlD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
E	PF00022	e6znlE2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
F	PF00022	e6znlF2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
G	PF00022	e6znlG2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
I	PF00022	e6znlI2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
H	PF00022	e6znlH1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
J	PF00022	e6znlJ1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: PF00022	ECOD (1.6)
K	PF01267	e6znlK2	A: alpha bundles	X: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	H: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	T: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz	F: PF01267	ECOD (1.6)
K	PF01267	e6znlK1	A: a+b two layers	X: a+b domain in Capz (From Topology)	H: a+b domain in Capz (From Topology)	T: a+b domain in Capz	F: PF01267	ECOD (1.6)
K	PF01267	e6znlK3	A: few secondary structure elements	X: beta-barrel domain in Capz (From Topology)	H: beta-barrel domain in Capz (From Topology)	T: beta-barrel domain in Capz	F: PF01267	ECOD (1.6)
L	PF01115	e6znlL2	A: alpha bundles	X: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	H: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz (From Topology)	T: alpha-helical domain in subunits of heterodimeric actin filament capping protein Capz	F: PF01115	ECOD (1.6)
L	PF01115	e6znlL1	A: a+b two layers	X: a+b domain in Capz (From Topology)	H: a+b domain in Capz (From Topology)	T: a+b domain in Capz	F: PF01115	ECOD (1.6)
L	PF01115	e6znlL3	A: few secondary structure elements	X: beta-barrel domain in Capz (From Topology)	H: beta-barrel domain in Capz (From Topology)	T: beta-barrel domain in Capz	F: PF01115	ECOD (1.6)
P [auth U]	F_UNCLASSIFIED	e6znlU1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: F_UNCLASSIFIED	ECOD (1.6)
Q [auth V]	PF21711	e6znlV1	A: beta duplicates or obligate multimers	X: Single-stranded left-handed beta-helix	H: Trimeric LpxA-like enzymes (From Topology)	T: Trimeric LpxA-like enzymes	F: PF21711	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, I	PF00022	Actin (Actin)	Actin	-	Family
R [auth Y]	PF05502	Dynactin p62 family (Dynactin_p62)	Dynactin p62 family	-	Family
H	PF00022	Actin (Actin)	Actin	-	Family
J	PF00022	Actin (Actin)	Actin	-	Family
K	PF01267	F-actin capping protein alpha subunit (F-actin_cap_A)	F-actin capping protein alpha subunit	-	Family
L	PF01115	F-actin capping protein, beta subunit (F_actin_cap_B)	F-actin capping protein, beta subunit	-	Family
M, N, T [auth m], U [auth n]	PF04912	Dynamitin (Dynamitin)	Dynamitin	-	Family
O, V [auth o]	PF07426	Dynactin subunit p22 (Dynactin_p22)	Dynactin subunit p22	-	Family
Q [auth V]	PF21711	Dynactin subunit 5 (DCTN5)	Dynactin subunit 5	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, I	ARP1 actin related protein 1 homolog A	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	-	cell periphery cell cortex intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle centrosome microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle
R [auth Y]	Dynactin subunit 4	-	-	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle sarcomere contractile muscle fiber protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle sarcomere contractile muscle fiber cytoplasm supramolecular fiber myofibril supramolecular polymer supramolecular complex cell periphery cell cortex centrosome microtubule organizing center actin filament bundle actomyosin stress fiber contractile actin filament bundle
S [auth Z], W [auth z]	Dynactin subunit 1	cytoskeletal protein binding microtubule binding protein binding binding tubulin binding kinase binding enzyme binding protein kinase binding	cellular process cell division establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration cellular component organization cell junction organization cellular process cell division establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration cellular component organization cell junction organization neuromuscular junction development synapse organization cellular component organization or biogenesis positive regulation of organelle organization regulation of cytoskeleton organization regulation of microtubule polymerization or depolymerization regulation of cellular process regulation of cellular component organization positive regulation of cellular component organization microtubule cytoskeleton organization positive regulation of biological process cellular component biogenesis regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly microtubule polymerization or depolymerization cellular component assembly positive regulation of protein polymerization protein-containing complex assembly positive regulation of cellular process protein polymerization regulation of biological process positive regulation of microtubule nucleation positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization biological regulation regulation of microtubule-based process microtubule polymerization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of microtubule nucleation regulation of organelle organization organelle organization microtubule nucleation regulation of microtubule polymerization regulation of protein polymerization positive regulation of microtubule polymerization regulation of supramolecular fiber organization microtubule-based process supramolecular fiber organization cytoskeleton organization regulation of microtubule cytoskeleton organization multicellular organismal process system process nervous system process neuromuscular process membrane organization cellular component disassembly nuclear membrane disassembly membrane disassembly nuclear membrane organization nucleus organization nuclear envelope organization endomembrane system organization organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly non-motile cilium assembly cilium organization cell projection assembly regulation of mitotic spindle organization mitotic cell cycle cell cycle regulation of cell cycle microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process regulation of cell cycle process regulation of spindle organization mitotic spindle organization mitotic cell cycle process spindle localization establishment or maintenance of cell polarity establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation establishment of cell polarity establishment of mitotic spindle orientation developmental process multicellular organism development spinal cord development central nervous system development anatomical structure development ventral spinal cord development nervous system development system development vesicle localization establishment of melanosome localization establishment of vesicle localization cellular pigmentation pigment granule transport establishment of pigment granule localization pigmentation pigment granule localization melanosome transport melanosome localization vesicle-mediated transport endosomal transport cytosolic transport retrograde transport, endosome to Golgi behavior motor behavior microtubule organizing center organization centriole-centriole cohesion centrosome cycle positive regulation of neuromuscular junction development regulation of synapse organization regulation of synapse structure or activity regulation of biological quality regulation of neuromuscular junction development neuron projection maintenance neuron projection organization microtubule anchoring at microtubule organizing center microtubule anchoring at centrosome microtubule anchoring cellular homeostasis neuron cellular homeostasis homeostatic process	protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton protein-containing complex membrane membrane protein complex cellular anatomical entity retromer complex endomembrane system intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle cell periphery cell cortex cytoplasm membrane-bounded organelle organelle envelope nuclear envelope nucleus intracellular membrane-bounded organelle centrosome microtubule organizing center polymeric cytoskeletal fiber microtubule end supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule plus-end centriole cytosol cell projection cilium intracellular protein-containing complex centriolar subdistal appendage plasma membrane bounded cell projection cell leading edge mitotic spindle intercellular bridge chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome somatodendritic compartment cell body neuronal cell body axon neuron projection microtubule associated complex catalytic complex dynein complex ciliary basal body
H	Actin, cytoplasmic 1	hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding hydrolase activity catalytic activity structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding nitric-oxide synthase binding protein binding enzyme binding identical protein binding cytoskeletal protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding	cellular response to stimulus cellular response to nitrogen compound response to cytochalasin B response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound cellular response to stimulus cellular response to nitrogen compound response to cytochalasin B response to organic substance response to stimulus response to endogenous stimulus response to organonitrogen compound cellular response to organic cyclic compound response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to chemical cellular process cellular response to organic substance response to organic cyclic compound regulation of localization import into cell cellular localization regulation of cellular process regulation of cellular component organization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse cellular component organization localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell cellular component organization or biogenesis regulation of endocytosis synaptic vesicle endocytosis regulation of biological process regulation of transport biological regulation regulation of vesicle-mediated transport establishment of localization endocytosis multicellular organismal process axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development system development developmental process plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process organic substance metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination positive regulation of cellular process DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination organic cyclic compound metabolic process positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic substance transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane localization within membrane regulation of protein localization to cell periphery protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane cell motility adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction organization cell-cell junction assembly transepithelial transport regulation of transepithelial transport apical protein localization protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction cell cycle regulation of cell cycle	cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cell projection cell leading edge cellular anatomical entity plasma membrane bounded cell projection lamellipodium membrane intracellular organelle intracellular anatomical structure cytoskeleton organelle intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytoplasm cytosol cluster of actin-based cell projections brush border synapse cell junction glutamatergic synapse apical junction complex cell-cell junction anchoring junction adherens junction axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton protein-containing complex catalytic complex protein-DNA complex NuA4 histone acetyltransferase complex chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex dense body plasma membrane nucleosome cytoplasmic ribonucleoprotein granule ribonucleoprotein granule Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex membrane-bounded organelle nucleus intracellular membrane-bounded organelle
J	Arp11	-	establishment of organelle localization cellular localization organelle transport along microtubule transport localization mitochondrion localization mitochondrion transport along microtubule organelle localization establishment of localization in cell transport along microtubule axonal transport of mitochondrion establishment of mitochondrion localization retrograde axonal transport intracellular transport establishment of organelle localization cellular localization organelle transport along microtubule transport localization mitochondrion localization mitochondrion transport along microtubule organelle localization establishment of localization in cell transport along microtubule axonal transport of mitochondrion establishment of mitochondrion localization retrograde axonal transport intracellular transport axonal transport establishment of localization establishment of mitochondrion localization, microtubule-mediated axo-dendritic transport microtubule-based transport cytoskeleton-dependent intracellular transport cellular process microtubule-based movement microtubule-based process retrograde axonal transport of mitochondrion	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle neuron projection cytoplasm axon protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle neuron projection cytoplasm axon axon cytoplasm neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection cell projection cytoplasm
K	Capping protein (Actin filament) muscle Z-line, alpha 1	cytoskeletal protein binding actin binding protein binding binding	regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization regulation of cellular process regulation of cellular component size negative regulation of biological process protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly regulation of biological process barbed-end actin filament capping negative regulation of cellular component organization actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of cellular component organization regulation of actin filament-based process cellular component organization regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization cellular component organization or biogenesis regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization biological regulation regulation of actin polymerization or depolymerization regulation of cellular component biogenesis organelle organization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization cellular process negative regulation of actin filament depolymerization protein depolymerization cytoskeleton organization regulation of anatomical structure size	intracellular anatomical structure cytoplasm cellular anatomical entity intracellular organelle protein-containing complex cytoskeleton organelle intracellular non-membrane-bounded organelle F-actin capping protein complex actin cytoskeleton non-membrane-bounded organelle
L	F-actin capping protein beta subunit	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding	filopodium assembly regulation of cellular component organization regulation of cellular process cell projection organization negative regulation of filopodium assembly negative regulation of biological process regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis negative regulation of plasma membrane bounded cell projection assembly cellular component assembly negative regulation of cellular process cellular component organization or biogenesis filopodium assembly regulation of cellular component organization regulation of cellular process cell projection organization negative regulation of filopodium assembly negative regulation of biological process regulation of filopodium assembly plasma membrane bounded cell projection assembly cellular component organization cellular component biogenesis negative regulation of plasma membrane bounded cell projection assembly cellular component assembly negative regulation of cellular process cellular component organization or biogenesis negative regulation of cell projection organization regulation of biological process plasma membrane bounded cell projection organization negative regulation of cellular component organization regulation of cell projection organization regulation of cell projection assembly biological regulation regulation of cellular component biogenesis regulation of plasma membrane bounded cell projection assembly cellular process cell projection assembly regulation of plasma membrane bounded cell projection organization organelle organization cytoskeleton organization developmental process anatomical structure morphogenesis anatomical structure development cell morphogenesis regulation of developmental process regulation of cell morphogenesis regulation of anatomical structure morphogenesis lamellipodium assembly regulation of lamellipodium assembly regulation of lamellipodium organization lamellipodium organization regulation of cellular component size protein-containing complex disassembly regulation of protein-containing complex disassembly actin filament depolymerization regulation of actin filament depolymerization actin filament capping actin filament-based process negative regulation of supramolecular fiber organization regulation of biological quality negative regulation of actin filament polymerization cellular component disassembly barbed-end actin filament capping actin filament organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization actin polymerization or depolymerization protein polymerization regulation of actin filament organization actin cytoskeleton organization actin filament polymerization protein-containing complex organization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization protein depolymerization regulation of anatomical structure size	protein-containing complex intracellular anatomical structure WASH complex cytoplasm cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex protein-containing complex intracellular anatomical structure WASH complex cytoplasm cellular anatomical entity sarcomere intracellular organelle organelle intracellular non-membrane-bounded organelle contractile muscle fiber supramolecular fiber myofibril supramolecular polymer supramolecular complex non-membrane-bounded organelle cytoskeleton F-actin capping protein complex actin cytoskeleton
M, N, T [auth m], U [auth n]	Dynactin subunit 2	-	microtubule-based process cellular process	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle membrane cytoplasm protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle membrane cytoplasm catalytic complex dynein complex centrosome microtubule organizing center polymeric cytoskeletal fiber supramolecular fiber microtubule supramolecular polymer supramolecular complex
O, V [auth o]	Dynactin subunit 3	-	cytoskeleton-dependent cytokinesis cellular process cytokinesis cell division cell cycle cell cycle process	midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex actin cytoskeleton dynactin complex microtubule associated complex midbody cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex actin cytoskeleton dynactin complex microtubule associated complex chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm cell division site cell periphery cleavage furrow membrane plasma membrane plasma membrane region centrosome microtubule organizing center
P [auth U]	Dynactin 6	protein-containing complex binding binding dynein complex binding	microtubule cytoskeleton organization mitotic cell cycle mitotic spindle organization cellular component organization organelle organization mitotic cell cycle process cellular process microtubule-based process cell cycle cellular component organization or biogenesis cytoskeleton organization microtubule cytoskeleton organization involved in mitosis spindle organization cell cycle process	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm centrosome microtubule organizing center
Q [auth V]	Dynactin subunit 5	-	developmental process heart development multicellular organismal process animal organ development ventricular septum development circulatory system development multicellular organism development cardiac septum development cardiac chamber development anatomical structure development cardiac ventricle development system development coronary vasculature development vasculature development developmental process heart development multicellular organismal process animal organ development ventricular septum development circulatory system development multicellular organism development cardiac septum development cardiac chamber development anatomical structure development cardiac ventricle development system development coronary vasculature development vasculature development blood vessel development artery development aorta development	protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region protein-containing complex intracellular anatomical structure cellular anatomical entity actin cytoskeleton dynactin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule associated complex microtubule cytoskeleton non-membrane-bounded organelle chromosome chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome cytoplasm membrane-bounded organelle nuclear membrane membrane nucleus intracellular membrane-bounded organelle endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen centrosome microtubule organizing center

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, I	IPR020902	Actin/actin-like conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, I	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, I	IPR004000	Actin family	Family
R [auth Y]	IPR008603	Dynactin subunit 4	Family
S [auth Z], W [auth z]	IPR000938	CAP Gly-rich domain	Domain
S [auth Z], W [auth z]	IPR036859	CAP Gly-rich domain superfamily	Homologous Superfamily
S [auth Z], W [auth z]	IPR022157	Dynein associated protein	Domain
H	IPR020902	Actin/actin-like conserved site	Conserved Site
H	IPR004001	Actin, conserved site	Conserved Site
H	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
H	IPR004000	Actin family	Family
J	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
J	IPR004000	Actin family	Family
K	IPR002189	F-actin-capping protein subunit alpha	Family
K	IPR042489	F-actin capping protein, alpha subunit, domain 1	Homologous Superfamily
K	IPR037282	F-actin-capping protein subunit alpha/beta	Homologous Superfamily
K	IPR017865	F-actin capping protein, alpha subunit, conserved site	Conserved Site
K	IPR042276	F-actin-capping protein subunit alpha/beta, domain 2	Homologous Superfamily
L	IPR019771	F-actin capping protein, beta subunit, conserved site	Conserved Site
L	IPR001698	F-actin-capping protein subunit beta	Family
L	IPR043175	F-actin-capping protein subunit beta, N-terminal domain	Homologous Superfamily
L	IPR037282	F-actin-capping protein subunit alpha/beta	Homologous Superfamily
L	IPR042276	F-actin-capping protein subunit alpha/beta, domain 2	Homologous Superfamily
M, N, T [auth m], U [auth n]	IPR028133	Dynamitin	Family
O, V [auth o]	IPR009991	Dynactin subunit 3	Family
P [auth U]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
P [auth U]	IPR027777	Dynactin subunit 6	Family
Q [auth V]	IPR011004	Trimeric LpxA-like superfamily	Homologous Superfamily
Q [auth V]	IPR047125	Dynactin subunit 5	Family