6ZFV

Solution NMR structure of human GATA2 N-terminal zinc finger domain

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6zfva_	Small proteins	Glucocorticoid receptor-like (DNA-binding domain)	Glucocorticoid receptor-like (DNA-binding domain)	Erythroid transcription factor GATA-1	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00320	e6zfvA1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: PF00320	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00320	GATA zinc finger (GATA)	GATA zinc finger	This domain uses four cysteine residues to coordinate a zinc ion. This domain binds to DNA. Two GATA zinc fingers are found in the GATA transcription factors. However there are several proteins which only contain a single copy of the domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Endothelial transcription factor GATA-2	transcription factor binding transcription coregulator binding protein binding binding C2H2 zinc finger domain binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding organic cyclic compound binding transcription factor binding transcription coregulator binding protein binding binding C2H2 zinc finger domain binding protein domain specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein-containing complex binding chromatin binding transcription coactivator binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development multicellular organismal process cellular developmental process cell differentiation in spinal cord nervous system development generation of neurons multicellular organism development central nervous system neuron differentiation developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development multicellular organismal process cellular developmental process cell differentiation in spinal cord nervous system development generation of neurons multicellular organism development central nervous system neuron differentiation neurogenesis spinal cord development central nervous system development neuron differentiation cell differentiation ventral spinal cord interneuron differentiation ventral spinal cord development cellular process system development neuroblast proliferation cell population proliferation neural precursor cell proliferation negative regulation of hematopoietic progenitor cell differentiation regulation of biological process regulation of cellular process regulation of developmental process negative regulation of developmental process hemopoiesis biological regulation negative regulation of biological process cell development regulation of cell differentiation negative regulation of cellular process negative regulation of cell differentiation regulation of hematopoietic progenitor cell differentiation hematopoietic progenitor cell differentiation central nervous system neuron development neuron development myeloid leukocyte differentiation eosinophil fate commitment eosinophil differentiation granulocyte differentiation myeloid cell differentiation cell fate commitment leukocyte differentiation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of cell population proliferation endothelial cell proliferation positive regulation of biological process angiogenesis tube morphogenesis positive regulation of endothelial cell proliferation epithelial cell proliferation positive regulation of cellular process blood vessel development positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel morphogenesis tube development blood vessel endothelial cell proliferation involved in sprouting angiogenesis positive regulation of epithelial cell proliferation sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis regulation of endothelial cell proliferation regulation of cell population proliferation anatomical structure formation involved in morphogenesis regulation of epithelial cell proliferation localization import into cell transport phagocytosis endocytosis establishment of localization vesicle-mediated transport cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process establishment of organelle localization regulation of immune effector process regulation of localization regulated exocytosis regulation of myeloid leukocyte mediated immunity response to stimulus cell activation involved in immune response leukocyte degranulation myeloid leukocyte activation myeloid leukocyte mediated immunity positive regulation of leukocyte degranulation positive regulation of regulated secretory pathway establishment of localization in cell leukocyte mediated immunity regulation of immune system process positive regulation of mast cell degranulation positive regulation of immune system process immune response vacuolar localization mast cell degranulation immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis lysosome localization cellular localization positive regulation of secretion by cell positive regulation of exocytosis regulation of mast cell degranulation leukocyte activation regulation of regulated secretory pathway secretion by cell regulation of secretion by cell positive regulation of secretion organelle localization leukocyte activation involved in immune response mast cell activation positive regulation of immune effector process regulation of leukocyte degranulation mast cell mediated immunity secretion regulation of transport cell activation export from cell regulation of vesicle-mediated transport myeloid cell activation involved in immune response mast cell activation involved in immune response positive regulation of transport immune system process regulation of exocytosis regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell development regulation of multicellular organismal process negative regulation of macrophage differentiation regulation of macrophage differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of leukocyte differentiation regulation of myeloid cell differentiation macrophage differentiation regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of immune system process regulation of hemopoiesis negative regulation of multicellular organismal process negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation regulation of neurogenesis negative regulation of neuroblast proliferation regulation of nervous system development negative regulation of neurogenesis negative regulation of nervous system development regulation of neural precursor cell proliferation negative regulation of cell population proliferation forebrain development regulation of forebrain neuron differentiation head development forebrain generation of neurons brain development forebrain neuron differentiation regulation of neuron differentiation positive regulation of cellular component organization regulation of cellular component organization cellular component organization positive regulation of endocytosis cellular component organization or biogenesis regulation of endocytosis regulation of phagocytosis positive regulation of phagocytosis regulation of primary metabolic process nucleobase-containing compound metabolic process DNA-templated transcription regulation of RNA metabolic process regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription RNA metabolic process positive regulation of miRNA transcription positive regulation of miRNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process miRNA transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA biosynthetic process regulation of miRNA transcription positive regulation of developmental process positive regulation of cell differentiation myeloid cell homeostasis erythrocyte homeostasis erythrocyte differentiation regulation of erythrocyte differentiation positive regulation of erythrocyte differentiation positive regulation of myeloid cell differentiation fat cell differentiation hematopoietic stem cell homeostasis glandular epithelial cell development epithelium development glandular epithelial cell maturation developmental maturation tissue development epithelial cell differentiation glandular epithelial cell differentiation epithelial cell development columnar/cuboidal epithelial cell development anatomical structure maturation columnar/cuboidal epithelial cell differentiation epithelial cell maturation cell maturation columnar/cuboidal epithelial cell maturation brown fat cell differentiation somatic stem cell population maintenance maintenance of cell number stem cell population maintenance definitive hemopoiesis response to organic substance response to lipid response to chemical negative regulation of cellular metabolic process negative regulation of RNA biosynthetic process transcription by RNA polymerase II negative regulation of nucleobase-containing compound metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of cellular biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process negative regulation of macromolecule metabolic process negative regulation of biosynthetic process positive regulation of transcription by RNA polymerase II positive regulation of locomotion regulation of cell motility cell migration involved in sprouting angiogenesis regulation of blood vessel endothelial cell migration endothelial cell migration positive regulation of cell migration positive regulation of epithelial cell migration tissue migration ameboidal-type cell migration positive regulation of cell motility regulation of cell migration blood vessel endothelial cell migration regulation of endothelial cell migration epithelial cell migration cell migration positive regulation of cell migration involved in sprouting angiogenesis cell motility regulation of epithelial cell migration locomotion regulation of cell migration involved in sprouting angiogenesis positive regulation of blood vessel endothelial cell migration epithelium migration regulation of locomotion positive regulation of endothelial cell migration GABAergic neuron differentiation positive regulation of cytosolic calcium ion concentration regulation of biological quality regulation of megakaryocyte differentiation megakaryocyte differentiation positive regulation of megakaryocyte differentiation positive regulation of membrane invagination regulation of phagocytosis, engulfment membrane invagination plasma membrane invagination membrane organization phagocytosis, engulfment positive regulation of phagocytosis, engulfment regulation of membrane invagination ear morphogenesis embryonic organ morphogenesis embryonic morphogenesis embryo development sensory organ morphogenesis inner ear morphogenesis animal organ morphogenesis embryonic organ development neuron maturation semicircular canal development urogenital system development placenta development chordate embryonic development in utero embryonic development embryonic placenta development embryo development ending in birth or egg hatching cellular response to stimulus negative regulation of signaling signaling regulation of signal transduction negative regulation of cell communication cell communication signal transduction regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus negative regulation of signal transduction Notch signaling pathway negative regulation of Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication gland development thyroid-stimulating hormone-secreting cell differentiation neuroepithelial cell differentiation neuroendocrine cell differentiation endocrine system development pituitary gland development diencephalon development adenohypophysis development cell fate determination negative regulation of fat cell differentiation regulation of brown fat cell differentiation negative regulation of brown fat cell differentiation regulation of fat cell differentiation positive regulation of neuron differentiation regulation of vasculature development regulation of anatomical structure morphogenesis positive regulation of angiogenesis positive regulation of vasculature development regulation of angiogenesis positive regulation of multicellular organismal process commitment of neuronal cell to specific neuron type in forebrain forebrain neuron fate commitment neuron fate commitment wound healing angiogenesis involved in wound healing vascular wound healing response to stress response to wounding neuron migration negative regulation of endothelial cell apoptotic process regulation of epithelial cell apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death epithelial cell apoptotic process negative regulation of apoptotic process negative regulation of epithelial cell apoptotic process endothelial cell apoptotic process apoptotic process programmed cell death regulation of endothelial cell apoptotic process negative regulation of gene expression hindbrain development cell differentiation in hindbrain primitive hemopoiesis regulation of primitive erythrocyte differentiation embryonic hemopoiesis primitive erythrocyte differentiation	protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle protein-containing complex transcription regulator complex intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR000679	Zinc finger, GATA-type	Domain
A	IPR016374	Transcription factor, GATA-2/3	Family
A	IPR013088	Zinc finger, NHR/GATA-type	Homologous Superfamily
A	IPR039355	Transcription factor GATA	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P23769	myelodysplastic syndrome acute myeloid leukemia monocytopenia with susceptibility to infections deafness-lymphedema-leukemia syndrome lymphedema juvenile myelomonocytic leukemia chondromalacia Cardiovascular Abnormalities cartilage disease medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer psoriasis glioblastoma myelodysplastic syndrome acute myeloid leukemia monocytopenia with susceptibility to infections deafness-lymphedema-leukemia syndrome lymphedema juvenile myelomonocytic leukemia chondromalacia Cardiovascular Abnormalities cartilage disease medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia breast cancer psoriasis glioblastoma lung carcinoma malignant glioma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer interstitial cystitis large cell medulloblastoma lymphatic system disease malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm prostate carcinoma hematopoietic and lymphoid system neoplasm invasive ductal breast carcinoma lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.