Annotations: 6ZDY

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6zdya_	All alpha proteins	EF Hand-like	EF-hand	automated matches	automated matches	House mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF01023	e6zdyA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: PF01023	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein S100-A9	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding antioxidant activity calcium-dependent protein binding protein binding	regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process regulation of immune effector process multicellular organismal process regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms response to stimulus regulation of response to external stimulus response to biotic stimulus regulation of respiratory burst involved in inflammatory response response to stress regulation of response to stress innate immune response regulation of immune system process regulation of multicellular organismal process response to external biotic stimulus regulation of respiratory burst production of molecular mediator involved in inflammatory response regulation of biological process respiratory burst involved in defense response defense response immune response response to other organism regulation of innate immune response biological regulation defense response to symbiont response to external stimulus regulation of inflammatory response immune effector process respiratory burst regulation of response to stimulus immune system process defense response to other organism respiratory burst involved in inflammatory response regulation of immune response metabolic process inflammatory response regulation of metabolic process positive regulation of biological process positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response positive regulation of defense response regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of primary metabolic process positive regulation of molecular function positive regulation of metabolic process regulation of cysteine-type endopeptidase activity involved in apoptotic process organic substance metabolic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process protein metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity organonitrogen compound metabolic process regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity primary metabolic process regulation of macromolecule metabolic process regulation of molecular function positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis macromolecule metabolic process chronic inflammatory response modulation of process of another organism cellular catabolic process catabolic process cellular metabolic process autophagy cellular process process utilizing autophagic mechanism epithelium migration tissue migration endothelial cell migration ameboidal-type cell migration epithelial cell migration cell migration cell motility cell chemotaxis cellular response to stimulus chemotaxis neutrophil chemotaxis neutrophil migration granulocyte migration leukocyte migration cellular response to chemical stimulus taxis granulocyte chemotaxis response to chemical myeloid leukocyte migration leukocyte chemotaxis locomotion apoptotic process cell death programmed cell death regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process post-transcriptional regulation of gene expression organic substance biosynthetic process regulation of biosynthetic process regulation of cellular metabolic process gene expression translation macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of translation regulation of macromolecule biosynthetic process positive regulation of peptide secretion regulation of localization nitrogen compound transport regulation of peptide secretion regulation of transport transport secretion organic substance transport regulation of peptide transport establishment of localization regulation of secretion peptide transport localization peptide secretion positive regulation of secretion positive regulation of transport amide transport cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization leukocyte migration involved in inflammatory response positive regulation of response to biotic stimulus pattern recognition receptor signaling pathway toll-like receptor signaling pathway regulation of signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of pattern recognition receptor signaling pathway activation of innate immune response regulation of toll-like receptor signaling pathway activation of immune response signaling immune response-regulating signaling pathway regulation of signaling positive regulation of innate immune response regulation of cell communication developmental process cellular developmental process astrocyte differentiation cell development nervous system development glial cell development multicellular organism development neurogenesis astrocyte development central nervous system development gliogenesis glial cell differentiation cell differentiation anatomical structure development system development cell-cell signaling autocrine signaling peptidyl-cysteine modification peptidyl-cysteine S-nitrosylation macromolecule modification peptidyl-amino acid modification protein modification process protein nitrosylation regulation of neuron projection development regulation of cellular component organization positive regulation of cellular component organization cell projection organization neuron projection development neuron differentiation positive regulation of neuron projection development positive regulation of cell projection organization positive regulation of cellular process plasma membrane bounded cell projection organization regulation of cell projection organization generation of neurons neuron development regulation of plasma membrane bounded cell projection organization neutrophil aggregation cell adhesion cell-cell adhesion leukocyte cell-cell adhesion leukocyte aggregation humoral immune response antimicrobial humoral response antimicrobial humoral immune response mediated by antimicrobial peptide positive regulation of cell communication positive regulation of signal transduction regulation of programmed cell death regulation of intrinsic apoptotic signaling pathway intracellular signal transduction positive regulation of apoptotic signaling pathway regulation of intracellular signal transduction intrinsic apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process positive regulation of intracellular signal transduction positive regulation of apoptotic process apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling regulation of body fluid levels positive regulation of coagulation positive regulation of blood coagulation regulation of response to wounding regulation of coagulation coagulation positive regulation of hemostasis regulation of biological quality response to wounding regulation of hemostasis positive regulation of response to wounding wound healing regulation of blood coagulation hemostasis blood coagulation positive regulation of wound healing regulation of wound healing positive regulation of multicellular organismal process plasma membrane organization integrin biosynthetic process endomembrane system organization membrane organization regulation of integrin biosynthetic process response to organic substance response to lipid response to oxygen-containing compound response to lipopolysaccharide response to bacterium response to molecule of bacterial origin	cell periphery plasma membrane membrane cellular anatomical entity cornified envelope protein-containing complex transmembrane transporter complex S100A9 complex membrane protein complex transporter complex intracellular anatomical structure cytoplasm calprotectin complex intracellular organelle cell periphery plasma membrane membrane cellular anatomical entity cornified envelope protein-containing complex transmembrane transporter complex S100A9 complex membrane protein complex transporter complex intracellular anatomical structure cytoplasm calprotectin complex intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle non-membrane-bounded organelle extracellular region extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.