6Z9C

Structure of human POLDIP2, a multifaceted adaptor protein in metabolism and genome stability

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF04379	ApaG domain (DUF525)	ApaG domain	-	Family
A	PF08755	Hemimethylated DNA-binding protein YccV like (YccV-like)	Hemimethylated DNA-binding protein YccV like	YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression [1]. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha hel ...	YccV is a hemimethylated DNA binding protein which has been shown to regulate dnaA gene expression [1]. The structure of one of the hypothetical proteins in this family has been solved and it forms a beta sheet structure with a terminating alpha helix.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Polymerase delta-interacting protein 2	DNA binding binding organic cyclic compound binding nucleic acid binding	cellular response to stimulus postreplication repair response to stimulus cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular response to stress response to stress organic substance biosynthetic process DNA repair translesion synthesis cellular metabolic process cellular response to stimulus postreplication repair response to stimulus cellular biosynthetic process DNA synthesis involved in DNA repair nucleobase-containing compound metabolic process nucleic acid biosynthetic process organic substance metabolic process cellular response to stress response to stress organic substance biosynthetic process DNA repair translesion synthesis cellular metabolic process primary metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process error-free translesion synthesis organic cyclic compound metabolic process biosynthetic process DNA damage response organic cyclic compound biosynthetic process metabolic process cellular process macromolecule metabolic process DNA biosynthetic process regulation of cellular process positive regulation of cell division cytoskeleton-dependent cytokinesis positive regulation of mitotic cytokinesis positive regulation of biological process mitotic cytokinesis mitotic cell cycle regulation of cell division regulation of mitotic cytokinesis positive regulation of cytokinesis positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process regulation of cytokinesis regulation of biological process regulation of cell cycle process biological regulation cytokinesis positive regulation of cell cycle mitotic cell cycle process cell division non-membrane-bounded organelle assembly microtubule cytoskeleton organization cellular component organization cellular component biogenesis cellular component assembly mitotic sister chromatid segregation cellular component organization or biogenesis chromosome segregation microtubule cytoskeleton organization involved in mitosis spindle organization mitotic nuclear division organelle assembly organelle fission chromosome organization sister chromatid segregation spindle assembly mitotic spindle organization mitotic spindle assembly organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization negative regulation of cellular catabolic process catabolic process macroautophagy autophagy negative regulation of biological process regulation of autophagy negative regulation of cellular metabolic process cellular catabolic process negative regulation of cellular process process utilizing autophagic mechanism negative regulation of catabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of catabolic process negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy regulation of cellular catabolic process regulation of metabolic process regulation of mitotic cell cycle positive regulation of mitotic cell cycle mitochondrion organization regulation of cellular component organization positive regulation of cellular component organization cell-substrate junction assembly positive regulation of cell-substrate junction organization cell adhesion cell junction assembly positive regulation of cell-substrate adhesion regulation of cell-substrate junction organization focal adhesion assembly positive regulation of focal adhesion assembly positive regulation of cellular component biogenesis regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion positive regulation of cell-matrix adhesion regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly cell junction organization cell-matrix adhesion regulation of cell-matrix adhesion cell-substrate junction organization regulation of focal adhesion assembly regulation of cell-substrate junction assembly cell population proliferation muscle cell proliferation smooth muscle cell proliferation vascular associated smooth muscle cell proliferation	membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle midbody cell-cell junction anchoring junction cell junction membrane-enclosed lumen nucleoid membrane-bounded organelle intracellular organelle intracellular anatomical structure mitochondrion organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle midbody cell-cell junction anchoring junction cell junction membrane-enclosed lumen nucleoid mitochondrial matrix intracellular organelle lumen organelle lumen intracellular non-membrane-bounded organelle mitochondrial nucleoid non-membrane-bounded organelle mitotic spindle cytoskeleton spindle microtubule cytoskeleton nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036623	Hemimethylated DNA-binding domain superfamily	Homologous Superfamily
A	IPR007474	ApaG domain	Domain
A	IPR036767	ApaG domain superfamily	Homologous Superfamily
A	IPR011722	Hemimethylated DNA-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y2S7	age-related macular degeneration lung cancer pancreatic ductal adenocarcinoma amyotrophic lateral sclerosis osteosarcoma wet macular degeneration hypertensive disorder ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.