Annotations: 6YVH

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F [auth H]	d6yvhh_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G [auth J]	d6yvhj_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I [auth L]	d6yvhl_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H [auth K]	d6yvhk_	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	Tandem AAA-ATPase domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth H]	SCOP2B Superfamily	RecA-like P-loop NTPases	8042951	3002019	SCOP2B (2022-06-29)
G [auth J]	SCOP2B Superfamily	RecA-like P-loop NTPases	8042951	3002019	SCOP2B (2022-06-29)
I [auth L]	SCOP2B Superfamily	RecA-like P-loop NTPases	8042951	3002019	SCOP2B (2022-06-29)
H [auth K]	SCOP2B Superfamily	RecA-like P-loop NTPases	8042951	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth F]	PF02854	e6yvhF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
A	PF02854	e6yvhA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
B	PF02854	e6yvhB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
D	PF02854	e6yvhD1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF02854	ECOD (1.6)
F [auth H]	PF00271	e6yvhH1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
G [auth J]	PF00271	e6yvhJ1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
I [auth L]	PF00271	e6yvhL1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)
H [auth K]	PF00271	e6yvhK1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00271	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
E [auth F]	1.25.40.180	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (utative)
A	1.25.40.180	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (utative)
B	1.25.40.180	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (utative)
D	1.25.40.180	Mainly Alpha	Alpha Horseshoe	Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat		CATH (utative)
F [auth H]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
G [auth J]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
I [auth L]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
H [auth K]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, D, E [auth F]	PF02854	MIF4G domain (MIF4G)	MIF4G domain	-	Repeat
F [auth H], G [auth J], H [auth K], I [auth L]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, D, E [auth F]	Pre-mRNA-splicing factor CWC22 homolog	RNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process RNA processing regulation of biosynthetic process regulation of mRNA processing regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of mRNA splicing, via spliceosome mRNA processing regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process RNA processing regulation of biosynthetic process regulation of mRNA processing regulation of biological process RNA splicing cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of RNA splicing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process cellular process regulation of macromolecule biosynthetic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process regulation of mRNA metabolic process regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome U2-type precatalytic spliceosome precatalytic spliceosome cytoplasm cytosol U2-type catalytic step 2 spliceosome
C, J [auth I], K [auth E], L [auth G]	Spliceosome-associated protein CWC27 homolog	-	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process RNA splicing RNA metabolic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen membrane-bounded organelle catalytic step 2 spliceosome protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle spliceosomal complex organelle ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type spliceosomal complex U2-type precatalytic spliceosome precatalytic spliceosome
F [auth H], G [auth J], H [auth K], I [auth L]	Eukaryotic initiation factor 4A-III	selenocysteine insertion sequence binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding ribonucleoprotein complex binding protein-containing complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding selenocysteine insertion sequence binding RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding ribonucleoprotein complex binding protein-containing complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding poly(A) binding poly-purine tract binding single-stranded RNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid helicase activity RNA helicase activity ATP-dependent activity, acting on RNA RNA stem-loop binding	regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of cellular process cellular biosynthetic process organonitrogen compound biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process regulation of primary metabolic process post-transcriptional regulation of gene expression negative regulation of translation organic substance metabolic process organic substance biosynthetic process negative regulation of cellular process protein metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process organonitrogen compound metabolic process cellular metabolic process regulation of protein metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression translation macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process regulation of translation negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process behavior multicellular organismal process exploration behavior modulation of chemical synaptic transmission signaling regulation of translation at synapse, modulating synaptic transmission cell communication synaptic signaling postsynaptic modulation of chemical synaptic transmission trans-synaptic signaling regulation of signaling cell-cell signaling regulation of translation at postsynapse regulation of translation at synapse chemical synaptic transmission regulation of translation at postsynapse, modulating synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of cell communication cellular response to endogenous stimulus cellular response to growth factor stimulus response to stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus cellular response to brain-derived neurotrophic factor stimulus response to nerve growth factor response to growth factor cellular localization nitrogen compound transport nucleocytoplasmic transport transport nuclear transport mRNA transport localization mRNA export from nucleus establishment of localization in cell RNA localization nuclear export nucleobase-containing compound transport RNA transport organic substance transport nucleic acid transport intracellular transport establishment of localization RNA export from nucleus establishment of RNA localization macromolecule localization developmental process embryonic organ morphogenesis embryonic cranial skeleton morphogenesis chordate embryonic development embryonic morphogenesis animal organ development embryo development multicellular organism development anatomical structure morphogenesis embryo development ending in birth or egg hatching skeletal system development anatomical structure development cranial skeletal system development animal organ morphogenesis embryonic skeletal system development skeletal system morphogenesis embryonic organ development embryonic skeletal system morphogenesis system development ribonucleoprotein complex biogenesis RNA metabolic process rRNA processing nucleobase-containing compound metabolic process cellular component biogenesis ribosome biogenesis cellular component organization or biogenesis RNA processing rRNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process nucleic acid catabolic process regulation of translational elongation translational readthrough negative regulation of translational elongation selenocysteine incorporation regulation of selenocysteine incorporation negative regulation of selenocysteine incorporation translational elongation positive regulation of protein metabolic process positive regulation of biological process positive regulation of translation positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of gene expression positive regulation of cellular biosynthetic process RNA splicing mRNA processing mRNA metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process RNA catabolic process mRNA catabolic process nucleobase-containing compound catabolic process catabolic process macromolecule catabolic process regulation of mRNA catabolic process nuclear-transcribed mRNA catabolic process regulation of catabolic process organic cyclic compound catabolic process regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay regulation of mRNA metabolic process organic substance catabolic process system process learning learning or memory nervous system process cognition associative learning cellular response to stimulus regulation of postsynaptic membrane potential regulation of system process regulation of signal transduction chemical synaptic transmission, postsynaptic modulation of excitatory postsynaptic potential regulation of multicellular organismal process signal transduction regulation of biological quality cell surface receptor signaling pathway regulation of nervous system process regulation of response to stimulus negative regulation of excitatory postsynaptic potential excitatory postsynaptic potential regulation of membrane potential response to organic substance response to chemical response to organic cyclic compound cellular response to inorganic substance cellular response to chemical stimulus response to selenite ion cellular response to selenite ion response to inorganic substance	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane nuclear speck nuclear body nucleoplasm U2-type spliceosomal complex protein-containing complex catalytic complex nuclear protein-containing complex U2-type catalytic step 1 spliceosome spliceosomal complex ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse exon-exon junction complex cell body neuronal cell body postsynapse

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, D, E [auth F]	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, D, E [auth F]	IPR003891	Initiation factor eIF-4 gamma, MA3	Domain
A, B, D, E [auth F]	IPR003890	MIF4G-like, type 3	Domain
C, J [auth I], K [auth E], L [auth G]	IPR029000	Cyclophilin-like domain superfamily	Homologous Superfamily
C, J [auth I], K [auth E], L [auth G]	IPR002130	Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain	Domain
C, J [auth I], K [auth E], L [auth G]	IPR044666	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, cyclophilin A-like	Family
C, J [auth I], K [auth E], L [auth G]	IPR020892	Cyclophilin-type peptidyl-prolyl cis-trans isomerase, conserved site	Conserved Site
F [auth H], G [auth J], H [auth K], I [auth L]	IPR000629	ATP-dependent RNA helicase DEAD-box, conserved site	Conserved Site
F [auth H], G [auth J], H [auth K], I [auth L]	IPR014014	RNA helicase, DEAD-box type, Q motif	Domain
F [auth H], G [auth J], H [auth K], I [auth L]	IPR011545	DEAD/DEAH box helicase domain	Domain
F [auth H], G [auth J], H [auth K], I [auth L]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth H], G [auth J], H [auth K], I [auth L]	IPR001650	Helicase, C-terminal domain-like	Domain
F [auth H], G [auth J], H [auth K], I [auth L]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, D, E [auth F]	Pharos: Q9HCG8	osteosarcoma ovarian cancer
C, J [auth I], K [auth E], L [auth G]	Pharos: Q6UX04	metaphyseal chondrodysplasia-retinitis pigmentosa syndrome atypical teratoid rhabdoid tumor large cell medulloblastoma rheumatoid arthritis glioblastoma malignant glioma ovarian cancer tuberculosis intellectual disability medulloblastoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
F [auth H], G [auth J], H [auth K], I [auth L]	Pharos: P38919	Richieri Costa-Pereira syndrome psoriasis adrenal cortex carcinoma glioblastoma large cell medulloblastoma ovarian cancer astrocytic tumor intellectual disability lung cancer diabetes mellitus invasive ductal breast carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.