Annotations: 6YTU

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF19284	Arc MA domain (Arc_MA)	Arc MA domain	This is the N-terminal matrix-like domain (MA) of Activity-Regulated Cytoskeleton-Associated protein (Arc). This domain might be involved in stabilising the relative domain orientations of the capside-like domain (CA) upon capsid assembly. Arc is a r ...	This is the N-terminal matrix-like domain (MA) of Activity-Regulated Cytoskeleton-Associated protein (Arc). This domain might be involved in stabilising the relative domain orientations of the capside-like domain (CA) upon capsid assembly. Arc is a regulator of synaptic scaling and dendrite remodelling [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Activity-regulated cytoskeleton-associated protein	RNA binding binding organic cyclic compound binding nucleic acid binding mRNA binding	localization intercellular transport transport cellular process establishment of localization vesicle-mediated intercellular transport vesicle-mediated transport behavior multicellular organismal process system process learning learning or memory nervous system process cognition localization intercellular transport transport cellular process establishment of localization vesicle-mediated intercellular transport vesicle-mediated transport behavior multicellular organismal process system process learning learning or memory nervous system process cognition positive regulation of cell communication regulation of cellular process modulation of chemical synaptic transmission signaling positive regulation of biological process cell communication long-term synaptic potentiation synaptic signaling regulation of biological quality positive regulation of cellular process regulation of synaptic plasticity trans-synaptic signaling regulation of biological process regulation of signaling biological regulation cell-cell signaling positive regulation of synaptic transmission chemical synaptic transmission regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of long-term synaptic potentiation regulation of cell communication positive regulation of signaling RNA transport nitrogen compound transport organic substance transport nucleic acid transport mRNA transport establishment of RNA localization macromolecule localization RNA localization nucleobase-containing compound transport cell projection organization neuron projection development multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation anatomical structure development regulation of synapse structure or activity dendritic spine morphogenesis synapse organization system development developmental process dendritic spine development dendritic spine organization postsynapse organization regulation of cell projection organization regulation of postsynapse organization nervous system development generation of neurons regulation of neuron projection development regulation of cellular component organization regulation of developmental process cellular developmental process plasma membrane bounded cell projection morphogenesis cell development cell morphogenesis cellular component organization neurogenesis dendrite development cellular component organization or biogenesis regulation of anatomical structure morphogenesis plasma membrane bounded cell projection organization dendrite morphogenesis cell morphogenesis involved in neuron differentiation anatomical structure morphogenesis regulation of synapse organization cell junction organization neuron development regulation of dendritic spine morphogenesis neuron projection organization regulation of plasma membrane bounded cell projection organization import into cell endocytosis regulation of cell morphogenesis endoderm development tissue development cell migration cell motility long-term memory memory organelle organization cytoskeleton organization regulation of neuronal synaptic plasticity negative regulation of signaling negative regulation of biological process negative regulation of synaptic transmission negative regulation of cell communication negative regulation of cellular process long-term synaptic depression regulation of long-term synaptic depression cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization anterior/posterior pattern specification pattern specification process regionalization regulation of localization cellular localization receptor internalization postsynaptic neurotransmitter receptor internalization regulation of receptor internalization vesicle-mediated transport in synapse establishment of localization in cell regulation of postsynaptic neurotransmitter receptor internalization regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport protein-containing complex localization neurotransmitter receptor internalization regulation of postsynaptic membrane neurotransmitter receptor levels postsynaptic endocytosis receptor-mediated endocytosis	postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic specialization membrane postsynaptic specialization synapse membrane plasma membrane cellular anatomical entity postsynaptic density membrane synaptic membrane cell periphery postsynaptic density postsynapse neuron to neuron synapse organelle cell junction postsynaptic membrane asymmetric synapse plasma membrane region cell cortex intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton intracellular non-membrane-bounded organelle actin cytoskeleton non-membrane-bounded organelle cytosol membrane microdomain membrane raft membrane-bounded organelle intracellular vesicle intracellular membrane-bounded organelle coated vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle clathrin-coated vesicle coated vesicle vesicle organelle membrane clathrin-coated vesicle membrane glutamatergic synapse neuron projection cytoplasm cytoplasmic ribonucleoprotein granule neuron projection cytoplasmic region plasma membrane bounded cell projection cytoplasm plasma membrane bounded cell projection ribonucleoprotein granule cell projection neuronal ribonucleoprotein granule supramolecular complex endosome postsynaptic endosome endomembrane system endosome membrane early endosome early endosome membrane neuron spine dendritic spine somatodendritic compartment dendrite dendritic tree extracellular vesicle extracellular organelle extracellular region extracellular membrane-bounded organelle cell body neuronal cell body acrosomal vesicle secretory granule secretory vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR023263	Activity-regulated cytoskeleton-associated protein	Family
A, B	IPR048965	Activity-regulated cytoskeleton-associated protein, capsid domain	Domain
A, B	IPR045557	Activity-regulated cytoskeleton-associated protein, N-terminal domain	Domain
A, B	IPR040814	Activity-regulated cytoskeleton-associated protein, C-terminal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q7LC44	Alzheimer disease cocaine abuse cocaine dependence medulloblastoma non-small cell lung carcinoma Presenile dementia atypical teratoid rhabdoid tumor Down syndrome lung adenocarcinoma movement disorder osteosarcoma schizophrenia breast cancer duodenal ulcer gastric carcinoma Alzheimer disease cocaine abuse cocaine dependence medulloblastoma non-small cell lung carcinoma Presenile dementia atypical teratoid rhabdoid tumor Down syndrome lung adenocarcinoma movement disorder osteosarcoma schizophrenia breast cancer duodenal ulcer gastric carcinoma malignant ependymoma pituitary cancer chronic atrophic gastritis invasive ductal breast carcinoma

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B	ACE	RESID: AA0041 , AA0042 , AA0043 , AA0044 , AA0045 , AA0046 , AA0049 , AA0050 , AA0051 , AA0052 , AA0053 , AA0054 , AA0354 PSI-MOD : N-acetyl-L-alanine MOD:00050 , N-acetyl-L-aspartic acid MOD:00051 , N-acetyl-L-cysteine MOD:00052 , N-acetyl-S-archeol-cysteine MOD:00897 , N-acetyl-L-glutamic acid MOD:00053 , N-acetyl-L-glutamine MOD:00054 , N-acetylglycine MOD:00055 , N-acetyl-L-methionine MOD:00058 , N-acetyl-L-proline MOD:00059 , N-acetyl-L-serine MOD:00060 , N,O-diacetylated L-serine MOD:00648 , N-acetyl-L-threonine MOD:00061 , N-acetyl-L-tyrosine MOD:00062 , N-acetyl-L-valine MOD:00063 , N2-acetyl-L-arginine MOD:00359

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.