6YHM

Crystal structure of the C-terminal domain of CNFy from Yersinia pseudotuberculosis

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad6yhma1 Alpha and beta proteins (a+b) CNF1/YfiH-like putative cysteine hydrolases CNF1/YfiH-like putative cysteine hydrolases Type 1 cytotoxic necrotizing factor, catalytic domain automated matches (Yersinia pseudotuberculosis ) [TaxId: 633 ], SCOPe (2.08)
Ad6yhma2 Artifacts Tags Tags Tags N-terminal Tags (Yersinia pseudotuberculosis ) [TaxId: 633 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APF05785e6yhmA1 A: a+b four layersX: CNF1/YfiH-like putative cysteine hydrolases (From Topology)H: CNF1/YfiH-like putative cysteine hydrolases (From Topology)T: CNF1/YfiH-like putative cysteine hydrolasesF: PF05785ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF05785Rho-activating domain of cytotoxic necrotizing factor (CNF1)Rho-activating domain of cytotoxic necrotizing factorThis family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the acti ...This family consists of several bacterial cytotoxic necrotizing factor proteins as well as related dermonecrotic toxin (DNT) from Bordetella species. Cytotoxic necrotizing factor 1 (CNF1) causes necrosis of rabbit skin and re-organisation of the actin cytoskeleton in cultured cells [1]. Bordetella dermonecrotic toxin (DNT) stimulates the assembly of actin stress fibres and focal adhesions by deamidating or polyaminating Gln63 of the small GTPase Rho. DNT is an A-B toxin which is composed of an N-terminal receptor-binding (B) domain and a C-terminal enzymatically active (A) domain [2].
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR046673Dermonecrotic toxin, N-terminal domainDomain
IPR037040Cytotoxic necrotizing factor, Rho-activating domain superfamilyHomologous Superfamily
IPR011324Cytotoxic necrotizing factor-like, catalyticHomologous Superfamily
IPR008430Cytotoxic necrotizing factor, Rho-activating domainDomain
IPR031886Domain of unknown function DUF4765Domain