Annotations: 6YGB

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Acetyltransf_10_5	e6ygbA1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)
C	LSM	e6ygbC1	A: beta barrels	X: SH3	H: SH3	T: SH3	F: LSM	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family
B	PF04112	Mak10 subunit, NatC N(alpha)-terminal acetyltransferase (Mak10)	Mak10 subunit, NatC N(alpha)-terminal acetyltransferase	-	Family
C	PF01423	LSM domain (LSM)	LSM domain	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) i ...	The LSM domain contains Sm proteins as well as other related LSM (Like Sm) proteins. The U1, U2, U4/U6, and U5 small nuclear ribonucleoprotein particles (snRNPs) involved in pre-mRNA splicing contain seven Sm proteins (B/B', D1, D2, D3, E, F and G) in common, which assemble around the Sm site present in four of the major spliceosomal small nuclear RNAs. The U6 snRNP binds to the LSM (Like Sm) proteins [3]. Sm proteins are also found in archaebacteria, which do not have any splicing apparatus suggesting a more general role for Sm proteins. All Sm proteins contain a common sequence motif in two segments, Sm1 and Sm2, separated by a short variable linker. This family also includes the bacterial Hfq (host factor Q) proteins. Hfq are also RNA-binding proteins, that form hexameric rings.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	N-alpha-acetyltransferase 30	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process protein localization regulation of localization regulation of biological process cellular localization regulation of cellular process regulation of protein localization biological regulation localization regulation of cellular localization cellular macromolecule localization macromolecule localization	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex NatC complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex NatC complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	N-alpha-acetyltransferase 35, NatC auxiliary subunit	-	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process cellular catabolic process catabolic process macroautophagy autophagy process utilizing autophagic mechanism	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex NatC complex intracellular protein-containing complex
C	N-alpha-acetyltransferase 38, NatC auxiliary subunit	RNA binding binding organic cyclic compound binding nucleic acid binding	organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation organic substance metabolic process biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process RNA splicing RNA metabolic process mRNA processing mRNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex NatC complex intracellular protein-containing complex membrane-bounded organelle nucleus intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex NatC complex intracellular protein-containing complex membrane-bounded organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex precatalytic spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex U6 snRNP

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A	IPR044542	N-alpha-acetyltransferase 30-like	Family
A	IPR000182	GNAT domain	Domain
B	IPR007244	-alpha-acetyltransferase 35, NatC auxiliary subunit	Family
C	IPR001163	Sm domain, eukaryotic/archaea-type	Domain
C	IPR010920	LSM domain superfamily	Homologous Superfamily
C	IPR034110	LSM domain containing 1, Sm domain	Domain
C	IPR047575	Sm domain	Domain

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.