6YBB

Crystal structure of a native BcsE (217-523) - BcsR-BcsQ (R156E mutant) complex with c-di-GMP and ATP bound

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06564	e6ybbA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF06564	ECOD (1.6)
B	PF06564	e6ybbB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF06564	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06564	Cellulose biosynthesis protein BcsQ (CBP_BcsQ)	Cellulose biosynthesis protein BcsQ	This is a family of bacterial proteins involved in cellulose biosynthesis. (Roemling U. and Galperin M.Y. "Bacterial cellulose biosynthesis. Diversity of operons and subunits" (manuscript in preparation)). A second component of the extracellular matr ...	This is a family of bacterial proteins involved in cellulose biosynthesis. (Roemling U. and Galperin M.Y. "Bacterial cellulose biosynthesis. Diversity of operons and subunits" (manuscript in preparation)). A second component of the extracellular matrix of the multicellular morphotype (rdar) of Salmonella typhimurium and Escherichia coli is cellulose. The family does contain a P-loop sequence motif suggesting a nucleotide binding function, but this has not been confirmed.	Domain
C, D	PF10945	Cellulose biosynthesis protein BcsR-like (CBP_BcsR)	Cellulose biosynthesis protein BcsR-like	-	Family
E, F	PF10995	Cellulose biosynthesis protein BcsE (CBP_BcsE)	Cellulose biosynthesis protein BcsE	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Bacterial cellulose secretion regulator BcsQ, R156E mutant	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	-	intracellular anatomical structure cytoplasm cellular anatomical entity
C, D	Bacterial cellulose secretion regulator BcsR	-	carbohydrate metabolic process glucan biosynthetic process beta-glucan metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process beta-glucan biosynthetic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process biosynthetic process bacterial cellulose biosynthetic process carbohydrate metabolic process glucan biosynthetic process beta-glucan metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process beta-glucan biosynthetic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process biosynthetic process bacterial cellulose biosynthetic process organic substance biosynthetic process metabolic process cellular process cellulose biosynthetic process macromolecule metabolic process cellulose metabolic process	-
E, F	Bacterial cellulose secretion regulator BcsE, residues 217-523	guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding guanyl nucleotide binding binding cyclic nucleotide binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding nucleoside phosphate binding ion binding cyclic-di-GMP binding purine nucleotide binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	carbohydrate metabolic process glucan biosynthetic process beta-glucan metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process beta-glucan biosynthetic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process biosynthetic process organic substance biosynthetic process carbohydrate metabolic process glucan biosynthetic process beta-glucan metabolic process polysaccharide biosynthetic process cellular biosynthetic process carbohydrate biosynthetic process cellular metabolic process primary metabolic process macromolecule biosynthetic process beta-glucan biosynthetic process polysaccharide metabolic process organic substance metabolic process glucan metabolic process biosynthetic process organic substance biosynthetic process metabolic process cellular process cellulose biosynthetic process macromolecule metabolic process cellulose metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR017746	Cellulose synthase operon protein BcsQ	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C, D	IPR024487	Cellulose biosynthesis protein BcsR-like	Family
E, F	IPR017745	Cellulose biosynthesis protein BcsE	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.