6XZW

Crystal structure of the meningococcal vaccine antigen fHbp in complex with a cross-reactive human Fab.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B [auth L]	d6xzwl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth L]	d6xzwl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C [auth H]	d6xzwh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth D]	Lipoprot_C_1st	e6xzwD1	A: beta barrels	X: Outer membrane meander beta-barrels	H: OMPA-like (From Topology)	T: OMPA-like	F: Lipoprot_C_1st	ECOD (1.6)
A [auth D]	Lipoprot_C_2nd	e6xzwD2	A: beta barrels	X: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	H: Factor H-binding protein (fHbp) N-terminal beta-barrel domain (From Topology)	T: Factor H-binding protein (fHbp) N-terminal beta-barrel domain	F: Lipoprot_C_2nd	ECOD (1.6)
B [auth L]	C1-set_4	e6xzwL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_4	ECOD (1.6)
B [auth L]	V-set	e6xzwL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set	ECOD (1.6)
C [auth H]	V-set_8	e6xzwH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
C [auth H]	C1-set_1	e6xzwH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: C1-set_1	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
B [auth L]	-	L-KAPPA	Homo sapiens (human)	IGKV3-2001, IGKJ202, IGKC*01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)
C [auth H]	-	VH-CH1	Homo sapiens (human)	IGHV3-1101, IGHV3-1104, IGHJ301, IGHJ401, IGHJ501, IGHJ502, IGHJ402, IGHJ403, IGHG103, IGHG108, IGHG1*06	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202415-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth L]	Light Chain	IGKV3	Kappa	lipoprot_c domain-containing protein	SAbDab (2024-04-19)
C [auth H]	Heavy Chain	IGHV3	-	lipoprot_c domain-containing protein	SAbDab (2024-04-19)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth D]	PF08794	Factor H binding protein, C-terminal (FHBP_C)	Factor H binding protein, C-terminal	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain c ...	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1-4]. The structure of the C-terminal domain consists of an anti-parallel beta barrel overlaid by a short alpha helical region [1,5]. This domain is highly similar to Transferrin-binding protein B beta barrel (Pfam:PF01298).	Domain
A [auth D]	PF20937	Factor H binding protein, N-terminal (FHBP_N)	Factor H binding protein, N-terminal	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1,2,3]. The structure of the N-terminal domain ...	Factor H binding protein (also known as GNA1870) is a surface exposed lipoprotein in Neisseria meningitidis that is a potent antigen and a potential candidate for a vaccine against meningococcal disease [1,2,3]. The structure of the N-terminal domain consists of a more unusual taco-shaped beta-barrel fold characterised by higher intrinsic flexibility than the C-terminal one [4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	Lipoprot_C domain-containing protein	-	-	membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle cellular anatomical entity bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle cell periphery cell outer membrane external encapsulating structure membrane cell envelope membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle cellular anatomical entity bacterial extracellular vesicle vesicle extracellular membrane-bounded organelle cell periphery cell outer membrane external encapsulating structure membrane cell envelope outer membrane
B [auth L]	Fab 4B3 (light chain)	-	-	-
C [auth H]	Fab 4B3 (heavy chain)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR011250	Outer membrane protein/outer membrane enzyme PagP, beta-barrel	Homologous Superfamily
A [auth D]	IPR014902	Factor H binding protein-like, C-terminal	Domain
A [auth D]	IPR049377	Factor H binding protein, N-terminal	Domain
A [auth D]	IPR049378	Factor H binding protein	Family

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.