6XVI

Crystal structure of Megabody Mb-Nb207-c7HopQ_A12

External Resource: Annotation

Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF07686	e6xviA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
A	PF18304	e6xviA1	A: alpha bundles	X: SabA N-terminal extracellular adhesion domain (From Topology)	H: SabA N-terminal extracellular adhesion domain (From Topology)	T: SabA N-terminal extracellular adhesion domain	F: PF18304	ECOD (1.6)
B	PF07686	e6xviB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B	PF18304	e6xviB1	A: alpha bundles	X: SabA N-terminal extracellular adhesion domain (From Topology)	H: SabA N-terminal extracellular adhesion domain (From Topology)	T: SabA N-terminal extracellular adhesion domain	F: PF18304	ECOD (1.6)
C	PF07686	e6xviC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C	PF18304	e6xviC1	A: alpha bundles	X: SabA N-terminal extracellular adhesion domain (From Topology)	H: SabA N-terminal extracellular adhesion domain (From Topology)	T: SabA N-terminal extracellular adhesion domain	F: PF18304	ECOD (1.6)
D	PF07686	e6xviD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
D	PF18304	e6xviD1	A: alpha bundles	X: SabA N-terminal extracellular adhesion domain (From Topology)	H: SabA N-terminal extracellular adhesion domain (From Topology)	T: SabA N-terminal extracellular adhesion domain	F: PF18304	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A, B, C, D	Heavy Chain	IGHV1	-	-	SAbDab (2024-05-24)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01856	Helicobacter outer membrane protein (HP_OMP)	Helicobacter outer membrane protein	-	Family
A, B, C, D	PF18304	SabA N-terminal extracellular adhesion domain (SabA_adhesion)	SabA N-terminal extracellular adhesion domain	This is the N-terminal extracellular adhesion domain of Sialic acid binding adhesin (SabA) present in Helicobacter pylori. The N-terminal domain of SabA functions as a sugar-binding adhesion domain with conserved disulfide bonds. Notably, these amino ...	This is the N-terminal extracellular adhesion domain of Sialic acid binding adhesin (SabA) present in Helicobacter pylori. The N-terminal domain of SabA functions as a sugar-binding adhesion domain with conserved disulfide bonds. Notably, these amino acid residues are not only conserved among SabA orthologs but also between SabA and BabA [1].	Domain

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR040838	SabA, N-terminal extracellular adhesion domain	Domain
A, B, C, D	IPR002718	Outer membrane protein, Helicobacter	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.