Annotations: 6XTY

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
J [auth D]	SCOP2B Superfamily	GINS helical bundle-like	8033896	3001594	SCOP2B (2022-06-29)
J [auth D]	SCOP2B Superfamily	PriA/YqbF domain	8033897	3000274	SCOP2B (2022-06-29)
G [auth A]	SCOP2B Superfamily	GINS helical bundle-like	8033891	3001594	SCOP2B (2022-06-29)
H [auth B]	SCOP2B Superfamily	GINS helical bundle-like	8033892	3001594	SCOP2B (2022-06-29)
H [auth B]	SCOP2B Superfamily	PriA/YqbF domain	8033893	3000274	SCOP2B (2022-06-29)
I [auth C]	SCOP2B Superfamily	GINS helical bundle-like	8035318	3001594	SCOP2B (2022-06-29)
I [auth C]	SCOP2B Superfamily	PriA/YqbF domain	8035319	3000274	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 2]	PF17207	e6xty22	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
A [auth 2]	PF17855	e6xty25	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
A [auth 2]	PF14551	e6xty23	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
A [auth 2]	PF00493	e6xty24	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
A [auth 2]	F_UNCLASSIFIED	e6xty21	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
J [auth D]	PF05916	e6xtyD1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
J [auth D]	PF16922	e6xtyD2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF16922	ECOD (1.6)
K [auth E]	PF02724	e6xtyE2	A: alpha arrays	X: HhH/H2TH	H: Cdc45 CID domain (From Topology)	T: Cdc45 CID domain	F: PF02724	ECOD (1.6)
K [auth E]	PF02724	e6xtyE3	A: a+b three layers	X: C-terminal domain in DHH phosphoesterases (From Topology)	H: C-terminal domain in DHH phosphoesterases (From Topology)	T: C-terminal domain in DHH phosphoesterases	F: PF02724	ECOD (1.6)
K [auth E]	PF02724	e6xtyE1	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: DHH phosphoesterases	F: PF02724	ECOD (1.6)
N [auth H]	PF12341	e6xtyH2	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
N [auth H]	PF20946	e6xtyH1	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
L [auth F]	PF12341	e6xtyF1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
L [auth F]	PF20946	e6xtyF2	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
M [auth G]	PF12341	e6xtyG1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: PF12341	ECOD (1.6)
M [auth G]	PF20946	e6xtyG2	A: alpha superhelices	X: Repetitive alpha hairpins	H: DNA polymerase alpha-binding protein Ctf4 C-terminal domain (From Topology)	T: DNA polymerase alpha-binding protein Ctf4 C-terminal domain	F: PF20946	ECOD (1.6)
C [auth 4]	PF17207	e6xty43	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
C [auth 4]	PF17855	e6xty45	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
C [auth 4]	PF14551	e6xty44	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
C [auth 4]	PF00493	e6xty41	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
C [auth 4]	PF17207	e6xty42	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
D [auth 5]	PF17207	e6xty54	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
D [auth 5]	PF17855	e6xty53	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
D [auth 5]	PF14551	e6xty51	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
D [auth 5]	PF00493	e6xty55	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
D [auth 5]	F_UNCLASSIFIED	e6xty52	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth 6]	PF17207	e6xty64	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
E [auth 6]	PF17855	e6xty61	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
E [auth 6]	PF14551	e6xty63	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
E [auth 6]	PF00493	e6xty62	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
E [auth 6]	PF17207	e6xty65	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
F [auth 7]	PF17207	e6xty72	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
F [auth 7]	PF17855	e6xty75	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
F [auth 7]	PF14551	e6xty74	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
F [auth 7]	PF00493	e6xty71	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
F [auth 7]	F_UNCLASSIFIED	e6xty73	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth A]	PF05916	e6xtyA2	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF1 N-terminal domain-like	F: PF05916	ECOD (1.6)
G [auth A]	F_UNCLASSIFIED	e6xtyA1	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth B]	PF05916	e6xtyB1	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
H [auth B]	F_UNCLASSIFIED	e6xtyB2	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth C]	PF05916	e6xtyC2	A: alpha bundles	X: GINS helical bundle-like (From Homology)	H: GINS helical bundle-like	T: PSF2 C-terminal domain-like	F: PF05916	ECOD (1.6)
I [auth C]	PF22466	e6xtyC1	A: a+b two layers	X: L9 N-domain-like	H: GINS/PriA/YqbF domain (From Topology)	T: GINS/PriA/YqbF domain	F: PF22466	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 2]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
A [auth 2]	PF12619	Mini-chromosome maintenance protein 2 (MCM2_N)	Mini-chromosome maintenance protein 2	-	Family
A [auth 2]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
A [auth 2]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
A [auth 2]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
J [auth D]	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
J [auth D]	PF16922	DNA replication complex GINS protein SLD5 C-terminus (SLD5_C)	DNA replication complex GINS protein SLD5 C-terminus	The C-terminal domain of DNA replication complex GINS protein SLD5 is important in the assembly of the GINS complex, a complex which is involved in initiation of DNA replication and progression of DNA replication forks [1].	Domain
K [auth E]	PF02724	CDC45-like protein (CDC45)	CDC45-like protein	-	Family
L [auth F], M [auth G], N [auth H]	PF12341	Minichromosome loss protein, Mcl1, middle region (Mcl1_mid)	Minichromosome loss protein, Mcl1, middle region	-	Repeat
L [auth F], M [auth G], N [auth H]	PF20946	DNA polymerase alpha-binding protein Ctf4, C-terminal domain (Ctf4_C)	DNA polymerase alpha-binding protein Ctf4, C-terminal domain	This domain is found at the C-terminal end of DNA polymerase alpha- binding protein Ctf4 from yeast, its human orthologue AND1, and similar proteins from eukaryotes. This accessory factor for DNA replication plays a role in accurately duplicating the ...	This domain is found at the C-terminal end of DNA polymerase alpha- binding protein Ctf4 from yeast, its human orthologue AND1, and similar proteins from eukaryotes. This accessory factor for DNA replication plays a role in accurately duplicating the genome in vivo. This domain folds into a helical extension that is linked to the beta-propeller domain (Pfam:PF12341) and protrudes from one face of the disk-shaped trimer formed by the protein. It is essential for binding of dynamic partner proteins, such as Pol alpha-primase [1-4].	Domain
B [auth 3]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
B [auth 3]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
B [auth 3]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
B [auth 3]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
C [auth 4]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
C [auth 4]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
C [auth 4]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
C [auth 4]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
D [auth 5]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
D [auth 5]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
D [auth 5]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
D [auth 5]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
E [auth 6]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
E [auth 6]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
E [auth 6]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
E [auth 6]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
F [auth 7]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
F [auth 7]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
F [auth 7]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
F [auth 7]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
G [auth A]	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
H [auth B]	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family
I [auth C]	PF05916	GINS complex protein (Sld5)	GINS complex protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 2]	DNA replication licensing factor MCM2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding histone binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein binding histone binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides enzyme binding cation binding metal ion binding single-stranded DNA binding	developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process developmental process ear development sensory organ development inner ear development cochlea development animal organ development anatomical structure development nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation cellular response to stimulus response to organic substance response to stimulus response to cytokine response to interleukin-4 cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular process cellular response to interleukin-4 cellular response to organic substance apoptotic process cell death programmed cell death regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process double-strand break repair DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair protein-containing complex organization protein-DNA complex assembly protein-DNA complex organization cellular component organization cellular component biogenesis cellular component assembly chromatin organization protein-containing complex assembly chromatin remodeling cellular component organization or biogenesis nucleosome assembly nucleosome organization mitotic DNA replication cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle cytoplasm MCM complex chromatin nuclear origin of replication recognition complex origin recognition complex chromosome, telomeric region chromosomal region
J [auth D]	DNA replication complex GINS protein SLD5	-	DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex cytoplasm
K [auth E]	Cell division control protein 45 homolog	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process regulation of biological process regulation of cell cycle process biological regulation DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling cellular process mitotic DNA replication DNA replication preinitiation complex assembly nuclear DNA replication cell cycle DNA replication mitotic cell cycle cellular component organization cellular component biogenesis protein-DNA complex organization mitotic DNA replication preinitiation complex assembly cellular component assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization protein-DNA complex assembly mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization double-strand break repair DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton cilium plasma membrane bounded cell projection ciliary basal body cell projection
L [auth F], M [auth G], N [auth H]	WD repeat and HMG-box DNA-binding protein 1	DNA binding binding organic cyclic compound binding nucleic acid binding protein-containing complex binding chromatin binding	cellular process cell cycle mitotic cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress cellular process cell cycle mitotic cell cycle cellular response to stimulus response to stimulus primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process organic substance metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair DNA-templated DNA replication DNA replication	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle nucleus membrane-enclosed lumen nuclear replication fork nuclear chromosome chromosome intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle replication fork non-membrane-bounded organelle nuclear lumen nucleoplasm
B [auth 3]	DNA replication licensing factor MCM3	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle membrane centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton MCM complex perinuclear region of cytoplasm cytoplasm alpha DNA polymerase:primase complex transferase complex nuclear replisome replication fork catalytic complex nuclear replication fork DNA polymerase complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex replisome chromosome, telomeric region chromosomal region
C [auth 4]	DNA replication licensing factor MCM4	ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA binding single-stranded DNA binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of DNA-templated DNA replication initiation DNA-templated DNA replication regulation of biological process DNA replication initiation biological regulation nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of DNA-templated DNA replication initiation DNA-templated DNA replication regulation of biological process DNA replication initiation biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle membrane MCM complex chromosome, telomeric region chromosomal region
D [auth 5]	DNA replication licensing factor MCM5	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair cell cycle DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle membrane MCM complex chromosome, telomeric region chromosomal region
E [auth 6]	DNA replication licensing factor MCM6	ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides identical protein binding protein binding DNA binding single-stranded DNA binding nucleic acid binding	nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process DNA-templated DNA replication DNA replication initiation regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair cellular process double-strand break repair via homologous recombination DNA repair mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle mitotic cell cycle process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM complex chromosome, telomeric region chromosomal region
F [auth 7]	DNA replication licensing factor MCM7	ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides DNA binding single-stranded DNA binding nucleic acid binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process primary metabolic process DNA metabolic process macromolecule metabolic process nucleic acid metabolic process regulation of biological process regulation of cellular process phosphorylation cellular metabolic process biological regulation regulation of cellular metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process regulation of phosphorylation regulation of phosphorus metabolic process phosphorus metabolic process regulation of metabolic process DNA-templated DNA replication DNA replication initiation cell population proliferation regulation of DNA-templated DNA replication initiation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of DNA replication regulation of DNA metabolic process double-strand break repair DNA recombination double-strand break repair via break-induced replication recombinational repair double-strand break repair via homologous recombination DNA repair cell cycle DNA strand elongation DNA strand elongation involved in DNA replication cellular response to chemical stimulus response to chemical cellular response to xenobiotic stimulus response to xenobiotic stimulus DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle membrane cytoplasm cytosol MCM complex chromatin chromosome, telomeric region chromosomal region
G [auth A]	DNA replication complex GINS protein PSF1	-	mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation organic substance metabolic process DNA strand elongation involved in cell cycle DNA replication cell cycle cell cycle process DNA-templated DNA replication primary metabolic process DNA metabolic process mitotic DNA replication DNA strand elongation involved in mitotic DNA replication nuclear DNA replication cell cycle DNA replication mitotic cell cycle nucleobase-containing compound metabolic process DNA strand elongation organic substance metabolic process DNA strand elongation involved in cell cycle DNA replication cell cycle cell cycle process DNA-templated DNA replication primary metabolic process DNA metabolic process DNA strand elongation involved in nuclear cell cycle DNA replication nucleic acid metabolic process organic cyclic compound metabolic process DNA replication mitotic cell cycle process metabolic process cellular process macromolecule metabolic process DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex cytoplasm
H [auth B]	DNA replication complex GINS protein PSF2	-	DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process DNA duplex unwinding DNA-templated DNA replication DNA geometric change chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process DNA unwinding involved in DNA replication cellular component organization nucleobase-containing compound metabolic process organic cyclic compound metabolic process organelle organization DNA replication organic substance metabolic process cellular process metabolic process cellular component organization or biogenesis macromolecule metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex
I [auth C]	DNA replication complex GINS protein PSF3	-	mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process organic cyclic compound metabolic process nuclear cell cycle DNA replication initiation DNA replication mitotic DNA replication DNA-templated DNA replication DNA replication initiation cell cycle DNA replication initiation nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process mitotic DNA replication initiation nucleic acid metabolic process mitotic cell cycle nucleobase-containing compound metabolic process organic cyclic compound metabolic process nuclear cell cycle DNA replication initiation DNA replication organic substance metabolic process mitotic cell cycle process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication cellular component organization organelle organization cellular component organization or biogenesis	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle GINS complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 2]	IPR031327	Mini-chromosome maintenance protein	Family
A [auth 2]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
A [auth 2]	IPR001208	MCM domain	Domain
A [auth 2]	IPR041562	MCM, AAA-lid domain	Domain
A [auth 2]	IPR008045	DNA replication licensing factor Mcm2	Family
A [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth 2]	IPR027925	MCM, N-terminal domain	Domain
A [auth 2]	IPR033762	MCM OB domain	Domain
A [auth 2]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
J [auth D]	IPR008591	GINS complex subunit Sld5	Family
J [auth D]	IPR038749	GINS complex protein Sld5, alpha-helical domain	Domain
J [auth D]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
J [auth D]	IPR021151	GINS subunit, domain A	Domain
J [auth D]	IPR031633	DNA replication complex GINS protein SLD5, C-terminal	Domain
K [auth E]	IPR003874	CDC45 family	Family
L [auth F], M [auth G], N [auth H]	IPR024977	Anaphase-promoting complex subunit 4-like, WD40 domain	Domain
L [auth F], M [auth G], N [auth H]	IPR019775	WD40 repeat, conserved site	Conserved Site
L [auth F], M [auth G], N [auth H]	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
L [auth F], M [auth G], N [auth H]	IPR001680	WD40 repeat	Repeat
L [auth F], M [auth G], N [auth H]	IPR009071	High mobility group box domain	Domain
L [auth F], M [auth G], N [auth H]	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
L [auth F], M [auth G], N [auth H]	IPR022100	Minichromosome loss protein Mcl1, middle region	Domain
L [auth F], M [auth G], N [auth H]	IPR048591	DNA polymerase alpha-binding protein Ctf4-like, C-terminal domain	Domain
L [auth F], M [auth G], N [auth H]	IPR036910	High mobility group box domain superfamily	Homologous Superfamily
B [auth 3]	IPR031327	Mini-chromosome maintenance protein	Family
B [auth 3]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
B [auth 3]	IPR003593	AAA+ ATPase domain	Domain
B [auth 3]	IPR001208	MCM domain	Domain
B [auth 3]	IPR041562	MCM, AAA-lid domain	Domain
B [auth 3]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth 3]	IPR027925	MCM, N-terminal domain	Domain
B [auth 3]	IPR008046	DNA replication licensing factor Mcm3	Family
B [auth 3]	IPR033762	MCM OB domain	Domain
B [auth 3]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
C [auth 4]	IPR031327	Mini-chromosome maintenance protein	Family
C [auth 4]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
C [auth 4]	IPR001208	MCM domain	Domain
C [auth 4]	IPR041562	MCM, AAA-lid domain	Domain
C [auth 4]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth 4]	IPR027925	MCM, N-terminal domain	Domain
C [auth 4]	IPR008047	Mini-chromosome maintenance complex protein 4	Family
C [auth 4]	IPR033762	MCM OB domain	Domain
C [auth 4]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
D [auth 5]	IPR031327	Mini-chromosome maintenance protein	Family
D [auth 5]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
D [auth 5]	IPR001208	MCM domain	Domain
D [auth 5]	IPR041562	MCM, AAA-lid domain	Domain
D [auth 5]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth 5]	IPR027925	MCM, N-terminal domain	Domain
D [auth 5]	IPR033762	MCM OB domain	Domain
D [auth 5]	IPR008048	DNA replication licensing factor Mcm5	Family
D [auth 5]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
E [auth 6]	IPR008049	DNA replication licensing factor Mcm6	Family
E [auth 6]	IPR041024	Mcm6, C-terminal winged-helix domain	Domain
E [auth 6]	IPR031327	Mini-chromosome maintenance protein	Family
E [auth 6]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
E [auth 6]	IPR001208	MCM domain	Domain
E [auth 6]	IPR041562	MCM, AAA-lid domain	Domain
E [auth 6]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
E [auth 6]	IPR027925	MCM, N-terminal domain	Domain
E [auth 6]	IPR033762	MCM OB domain	Domain
E [auth 6]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
F [auth 7]	IPR031327	Mini-chromosome maintenance protein	Family
F [auth 7]	IPR008050	DNA replication licensing factor Mcm7	Family
F [auth 7]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
F [auth 7]	IPR003593	AAA+ ATPase domain	Domain
F [auth 7]	IPR001208	MCM domain	Domain
F [auth 7]	IPR041562	MCM, AAA-lid domain	Domain
F [auth 7]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
F [auth 7]	IPR027925	MCM, N-terminal domain	Domain
F [auth 7]	IPR033762	MCM OB domain	Domain
F [auth 7]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
G [auth A]	IPR021151	GINS subunit, domain A	Domain
G [auth A]	IPR005339	GINS complex, subunit Psf1	Family
G [auth A]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
H [auth B]	IPR007257	DNA replication complex GINS protein Psf2	Family
H [auth B]	IPR021151	GINS subunit, domain A	Domain
H [auth B]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily
I [auth C]	IPR021151	GINS subunit, domain A	Domain
I [auth C]	IPR010492	GINS complex, subunit Psf3	Family
I [auth C]	IPR038437	GINS complex, subunit Psf3 superfamily	Homologous Superfamily
I [auth C]	IPR036224	GINS, helical bundle-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth 2]	Pharos: P49736	autosomal dominant nonsyndromic deafness 70 malignant colon neoplasm nonsyndromic genetic deafness nasopharyngeal carcinoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm psoriasis adrenal cortex carcinoma colonic neoplasm glioblastoma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma ovarian cancer pituitary cancer autosomal dominant nonsyndromic deafness 70 malignant colon neoplasm nonsyndromic genetic deafness nasopharyngeal carcinoma oligodendroglioma pancreatic intraductal papillary-mucinous neoplasm psoriasis adrenal cortex carcinoma colonic neoplasm glioblastoma large cell medulloblastoma malignant mesothelioma non-small cell lung carcinoma ovarian cancer pituitary cancer Sensorineural hearing loss, bilateral atypical teratoid rhabdoid tumor benign colon neoplasm ductal breast carcinoma in situ hepatocellular carcinoma lung adenocarcinoma malignant ependymoma medulloblastoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor autosomal dominant nonsyndromic deafness 1 breast cancer endometriosis invasive ductal breast carcinoma lung cancer malignant glioma
J [auth D]	Pharos: Q9BRT9	large cell medulloblastoma non-small cell lung carcinoma psoriasis malignant mesothelioma osteosarcoma medulloblastoma ovarian cancer
K [auth E]	Pharos: O75419	ovarian cancer adrenal cortex carcinoma craniosynostosis glioblastoma invasive ductal breast carcinoma lung cancer medulloblastoma non-small cell lung carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor ductal breast carcinoma in situ hepatocellular carcinoma large cell medulloblastoma malignant glioma Meier-Gorlin syndrome ovarian cancer adrenal cortex carcinoma craniosynostosis glioblastoma invasive ductal breast carcinoma lung cancer medulloblastoma non-small cell lung carcinoma primitive neuroectodermal tumor atypical teratoid rhabdoid tumor ductal breast carcinoma in situ hepatocellular carcinoma large cell medulloblastoma malignant glioma Meier-Gorlin syndrome osteosarcoma psoriasis breast cancer EAR, PATELLA, SHORT STATURE SYNDROME intellectual disability lung adenocarcinoma malignant mesothelioma Meier-Gorlin syndrome 7
L [auth F], M [auth G], N [auth H]	Pharos: O75717	atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida breast cancer large cell medulloblastoma malignant colon neoplasm medulloblastoma ovarian cancer primitive neuroectodermal tumor Crohn disease lung adenocarcinoma atypical teratoid rhabdoid tumor glioblastoma lung cancer malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm spina bifida breast cancer large cell medulloblastoma malignant colon neoplasm medulloblastoma ovarian cancer primitive neuroectodermal tumor Crohn disease lung adenocarcinoma malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma psoriasis
B [auth 3]	Pharos: P25205	adrenal cortex carcinoma exocrine pancreatic carcinoma lung cancer malignant glioma non-small cell lung carcinoma atypical teratoid rhabdoid tumor glioblastoma malignant colon neoplasm malignant mesothelioma pancreatic intraductal papillary-mucinous carcinoma breast cancer large cell medulloblastoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor
C [auth 4]	Pharos: P33991	primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency ovarian cancer X-linked adrenal hypoplasia congenita adrenal cortex carcinoma breast cancer endometriosis invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor attention deficit hyperactivity disorder, inattentive type breast carcinoma familial glucocorticoid deficiency primary immunodeficiency with natural-killer cell deficiency and adrenal insufficiency ovarian cancer X-linked adrenal hypoplasia congenita adrenal cortex carcinoma breast cancer endometriosis invasive ductal breast carcinoma lung cancer malignant mesothelioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor attention deficit hyperactivity disorder, inattentive type breast carcinoma familial glucocorticoid deficiency large cell medulloblastoma malignant colon neoplasm medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor ductal breast carcinoma in situ glioblastoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma
D [auth 5]	Pharos: P33992	Meier-Gorlin syndrome 8 plasma cell myeloma pilocytic astrocytoma psoriasis adrenal cortex carcinoma atopic eczema gastric carcinoma large cell medulloblastoma malignant glioma osteosarcoma ulcerative colitis Alcohol Use Disorder atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma Meier-Gorlin syndrome 8 plasma cell myeloma pilocytic astrocytoma psoriasis adrenal cortex carcinoma atopic eczema gastric carcinoma large cell medulloblastoma malignant glioma osteosarcoma ulcerative colitis Alcohol Use Disorder atypical teratoid rhabdoid tumor glioblastoma lymphoplasmacytic lymphoma malignant mesothelioma non-small cell lung carcinoma ovarian cancer primitive neuroectodermal tumor astrocytic tumor juvenile dermatomyositis malignant ependymoma medulloblastoma oligodendroglioma
E [auth 6]	Pharos: Q14566	Lactose Intolerance, Adult Type pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor tuberculosis adrenal cortex carcinoma endometriosis lactose intolerance large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor esophageal adenocarcinoma Lactose Intolerance, Adult Type pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor tuberculosis adrenal cortex carcinoma endometriosis lactose intolerance large cell medulloblastoma lymphoplasmacytic lymphoma medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor esophageal adenocarcinoma lactose intolerance adult type lung adenocarcinoma malignant colon neoplasm nasopharyngeal carcinoma ovarian cancer plasma cell myeloma Sjogren syndrome breast cancer inborn errors of metabolism lung cancer malignant mesothelioma non-small cell lung carcinoma
F [auth 7]	Pharos: P33993	adrenal cortex carcinoma chronic obstructive pulmonary disease idiopathic pulmonary fibrosis lung cancer malignant mesothelioma non-small cell lung carcinoma primitive neuroectodermal tumor astrocytic tumor endometriosis large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma atypical teratoid rhabdoid tumor glioblastoma adrenal cortex carcinoma chronic obstructive pulmonary disease idiopathic pulmonary fibrosis lung cancer malignant mesothelioma non-small cell lung carcinoma primitive neuroectodermal tumor astrocytic tumor endometriosis large cell medulloblastoma malignant ependymoma medulloblastoma oligodendroglioma atypical teratoid rhabdoid tumor glioblastoma lung adenocarcinoma malignant glioma nasopharyngeal carcinoma ovarian cancer
G [auth A]	Pharos: Q14691	malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor adrenal cortex carcinoma atypical teratoid rhabdoid tumor combined immunodeficiency due to GINS1 deficiency esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis malignant pancreatic neoplasm non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor adrenal cortex carcinoma atypical teratoid rhabdoid tumor combined immunodeficiency due to GINS1 deficiency esophageal adenocarcinoma hepatocellular carcinoma large cell medulloblastoma malignant glioma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema breast cancer ductal breast carcinoma in situ exocrine pancreatic carcinoma IgA glomerulonephritis lung adenocarcinoma malignant mesothelioma nasopharyngeal carcinoma pancreatic ductal adenocarcinoma pituitary cancer attention deficit hyperactivity disorder, inattentive type breast carcinoma endometriosis glioblastoma invasive ductal breast carcinoma lung cancer
H [auth B]	Pharos: Q9Y248	salivary gland adenoid cystic carcinoma adenoid cystic carcinoma ovarian cancer pituitary cancer acute myeloid leukemia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor salivary gland cancer breast cancer salivary gland adenoid cystic carcinoma adenoid cystic carcinoma ovarian cancer pituitary cancer acute myeloid leukemia atypical teratoid rhabdoid tumor ductal breast carcinoma in situ invasive ductal breast carcinoma lung cancer malignant glioma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous carcinoma primitive neuroectodermal tumor salivary gland cancer breast cancer endometriosis large cell medulloblastoma lung carcinoma Malignant neoplasm of salivary gland osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis adrenal cortex carcinoma breast carcinoma glioblastoma lung adenocarcinoma malignant ependymoma medulloblastoma
I [auth C]	Pharos: Q9BRX5	adrenal cortex carcinoma atypical teratoid rhabdoid tumor lung cancer medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor glioblastoma malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema large cell medulloblastoma malignant glioma adrenal cortex carcinoma atypical teratoid rhabdoid tumor lung cancer medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor glioblastoma malignant ependymoma nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atopic eczema large cell medulloblastoma malignant glioma non-small cell lung carcinoma primary biliary cholangitis