6XRS

Crystal structure of a GTP-binding protein EngA (Der homolog) from Neisseria gonorrhoeae bound to GDP

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KH_dom-like	e6xrsA3	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Probable GTPase Der, C-terminal domain (From Topology)	T: Probable GTPase Der, C-terminal domain	F: KH_dom-like	ECOD (1.6)
A	MnmE_helical_2nd	e6xrsA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
B	KH_dom-like	e6xrsB3	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Probable GTPase Der, C-terminal domain (From Topology)	T: Probable GTPase Der, C-terminal domain	F: KH_dom-like	ECOD (1.6)
B	MnmE_helical_2nd	e6xrsB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
D	KH_dom-like	e6xrsD3	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Probable GTPase Der, C-terminal domain (From Topology)	T: Probable GTPase Der, C-terminal domain	F: KH_dom-like	ECOD (1.6)
D	MnmE_helical_2nd	e6xrsD1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)
C	KH_dom-like	e6xrsC1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: Probable GTPase Der, C-terminal domain (From Topology)	T: Probable GTPase Der, C-terminal domain	F: KH_dom-like	ECOD (1.6)
C	MnmE_helical_2nd	e6xrsC2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: MnmE_helical_2nd	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF14714	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal (KH_dom-like)	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the ...	The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the C-terminal domain. This C-terminal domain resembles a KH domain but is missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2. This family has not been added to the KH clan since SCOP classifies it separately due to its missing the key KH motif/fold.	Domain
A, B, C, D	PF01926	50S ribosome-binding GTPase (MMR_HSR1)	50S ribosome-binding GTPase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	GTPase Der	pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding	cellular component biogenesis ribosome biogenesis ribonucleoprotein complex biogenesis cellular process cellular component organization or biogenesis	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR015946	K homology domain-like, alpha/beta	Homologous Superfamily
A, B, C, D	IPR003593	AAA+ ATPase domain	Domain
A, B, C, D	IPR016484	GTPase Der	Family
A, B, C, D	IPR032859	GTPase Der, C-terminal KH-domain-like	Domain
A, B, C, D	IPR031166	EngA-type guanine nucleotide-binding (G) domain	Domain
A, B, C, D	IPR005225	Small GTP-binding protein domain	Domain
A, B, C, D	IPR006073	GTP binding domain	Domain
A, B, C, D	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.