6XQJ
Structure of HIV-1 Vpr in complex with the human nucleotide excision repair protein hHR23A
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | PF09280 | e6xqjA2 | A: alpha arrays | X: HTH | H: XPC-binding domain (From Topology) | T: XPC-binding domain | F: PF09280 | ECOD (1.6) |
A | PF00627 | e6xqjA3 | A: alpha arrays | X: RuvA-C | H: RuvA-C, UBA, CRAL/TRIO-N, HBS1 (From Topology) | T: RuvA-C, UBA, CRAL/TRIO-N, HBS1 | F: PF00627 | ECOD (1.6) |
A | PF00522 | e6xqjA1 | A: alpha bundles | X: Viral accessory protein x (Vpx) / viral protein r (Vpr) (From Topology) | H: Viral accessory protein x (Vpx) / viral protein r (Vpr) (From Topology) | T: Viral accessory protein x (Vpx) / viral protein r (Vpr) | F: PF00522 | ECOD (1.6) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00627 | UBA/TS-N domain (UBA) | UBA/TS-N domain | This small domain is composed of three alpha helices. This family includes the previously defined UBA and TS-N domains. The UBA-domain (ubiquitin associated domain) is a novel sequence motif found in several proteins having connections to ubiquitin a ... | Domain | |
PF00522 | VPR/VPX protein (VPR) | VPR/VPX protein | - | Family | |
PF09280 | XPC-binding domain (XPC-binding) | XPC-binding domain | Members of this family adopt a structure consisting of four alpha helices, arranged in an array. They bind specifically and directly to the xeroderma pigmentosum group C protein (XPC) to initiate nucleotide excision repair [1]. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR004806 | UV excision repair protein Rad23 | Family | |
IPR036353 | XPC-binding domain superfamily | Homologous Superfamily | |
IPR015360 | XPC-binding domain | Domain | |
IPR015940 | Ubiquitin-associated domain | Domain | |
IPR041811 | RAD23A/RAD23B, UBA1 domain | Domain | |
IPR000626 | Ubiquitin-like domain | Domain | |
IPR029071 | Ubiquitin-like domain superfamily | Homologous Superfamily | |
IPR009060 | UBA-like superfamily | Homologous Superfamily | |
IPR006636 | Heat shock chaperonin-binding | Domain | |
IPR000012 | Retroviral VpR/VpX protein | Family |
Pharos: Disease Associations Pharos Homepage Annotation
Chains | Drug Target   | Associated Disease |
---|---|---|
P54725 | :