Annotations: 6XNQ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6xnqa1	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Adenine nucleotide alpha hydrolases-like	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
A	d6xnqa2	Alpha and beta proteins (a+b)	Argininosuccinate synthetase, C-terminal domain	Argininosuccinate synthetase, C-terminal domain	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
B	d6xnqb1	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Adenine nucleotide alpha hydrolases-like	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
B	d6xnqb2	Alpha and beta proteins (a+b)	Argininosuccinate synthetase, C-terminal domain	Argininosuccinate synthetase, C-terminal domain	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
C	d6xnqc1	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Adenine nucleotide alpha hydrolases-like	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
C	d6xnqc2	Alpha and beta proteins (a+b)	Argininosuccinate synthetase, C-terminal domain	Argininosuccinate synthetase, C-terminal domain	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
D	d6xnqd1	Alpha and beta proteins (a/b)	Adenine nucleotide alpha hydrolase-like	Adenine nucleotide alpha hydrolases-like	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)
D	d6xnqd2	Alpha and beta proteins (a+b)	Argininosuccinate synthetase, C-terminal domain	Argininosuccinate synthetase, C-terminal domain	automated matches	automated matches	(Legionella pneumophila subsp. pneumophila str. Philadelphia 1 ) [TaxId: 272624 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF20979	e6xnqA2	A: a+b complex topology	X: Argininosuccinate synthetase-C (From Topology)	H: Argininosuccinate synthetase-C (From Topology)	T: Argininosuccinate synthetase-C	F: PF20979	ECOD (1.6)
A	PF00764	e6xnqA1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00764	ECOD (1.6)
B	PF20979	e6xnqB2	A: a+b complex topology	X: Argininosuccinate synthetase-C (From Topology)	H: Argininosuccinate synthetase-C (From Topology)	T: Argininosuccinate synthetase-C	F: PF20979	ECOD (1.6)
B	PF00764	e6xnqB1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00764	ECOD (1.6)
C	PF20979	e6xnqC2	A: a+b complex topology	X: Argininosuccinate synthetase-C (From Topology)	H: Argininosuccinate synthetase-C (From Topology)	T: Argininosuccinate synthetase-C	F: PF20979	ECOD (1.6)
C	PF00764	e6xnqC1	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00764	ECOD (1.6)
D	PF20979	e6xnqD1	A: a+b complex topology	X: Argininosuccinate synthetase-C (From Topology)	H: Argininosuccinate synthetase-C (From Topology)	T: Argininosuccinate synthetase-C	F: PF20979	ECOD (1.6)
D	PF00764	e6xnqD2	A: a/b three-layered sandwiches	X: HUP domain-like	H: HUP domains (From Topology)	T: HUP domains	F: PF00764	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF20979	Arginosuccinate synthase C-terminal domain (Arginosuc_syn_C)	Arginosuccinate synthase C-terminal domain	This entry represents the C-terminal domain of the Arginosuccinate synthase enzyme.	Domain
A, B, C, D	PF00764	Arginosuccinate synthase N-terminal HUP domain (Arginosuc_synth)	Arginosuccinate synthase N-terminal HUP domain	This entry represents the N-terminal domain of the Arginosuccinate synthase enzyme. This domain is part of the HUP superfamily.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Argininosuccinate synthase	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding argininosuccinate synthase activity catalytic activity ligase activity, forming carbon-nitrogen bonds ligase activity	oxoacid metabolic process glutamine family amino acid biosynthetic process cellular biosynthetic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process arginine biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process organic substance metabolic process organic substance biosynthetic process oxoacid metabolic process glutamine family amino acid biosynthetic process cellular biosynthetic process organonitrogen compound biosynthetic process amino acid metabolic process organic acid metabolic process organic acid biosynthetic process arginine biosynthetic process alpha-amino acid metabolic process carboxylic acid biosynthetic process glutamine family amino acid metabolic process arginine metabolic process organic substance metabolic process organic substance biosynthetic process small molecule metabolic process organonitrogen compound metabolic process small molecule biosynthetic process cellular metabolic process carboxylic acid metabolic process primary metabolic process L-amino acid biosynthetic process L-amino acid metabolic process proteinogenic amino acid metabolic process amino acid biosynthetic process biosynthetic process proteinogenic amino acid biosynthetic process metabolic process cellular process alpha-amino acid biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR018223	Argininosuccinate synthase, conserved site	Conserved Site
A, B, C, D	IPR048268	Arginosuccinate synthase C-terminal domain	Domain
A, B, C, D	IPR001518	Argininosuccinate synthase	Family
A, B, C, D	IPR023434	Argininosuccinate synthase, type 1 subfamily	Family
A, B, C, D	IPR048267	Arginosuccinate synthase-like, N-terminal domain	Domain
A, B, C, D	IPR024074	Argininosuccinate synthetase, catalytic/multimerisation domain body	Homologous Superfamily
A, B, C, D	IPR014729	Rossmann-like alpha/beta/alpha sandwich fold	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.