Annotations: 6XKW

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth n]	PF00115	e6xkwn1	A: alpha superhelices	X: Cytochrome c oxidase subunit I-like	H: Cytochrome c oxidase subunit I-like (From Topology)	T: Cytochrome c oxidase subunit I-like	F: PF00115	ECOD (1.6)
B [auth o]	PF02433	e6xkwo1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF02433	ECOD (1.6)
C [auth p]	PF00034	e6xkwp1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF00034	ECOD (1.6)
C [auth p]	PF14715	e6xkwp2	A: extended segments	X: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	H: Cytochrome c oxidase subunit II-like, transmembrane region (From Topology)	T: Cytochrome c oxidase subunit II-like, transmembrane region	F: PF14715	ECOD (1.6)
F [auth E]	F_UNCLASSIFIED	e6xkwE3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth E]	PF00355	e6xkwE2	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
F [auth E]	PF10399	e6xkwE1	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: PF10399	ECOD (1.6)
K [auth R]	F_UNCLASSIFIED	e6xkwR3	A: beta sandwiches	X: ISP domain (From Topology)	H: ISP domain (From Topology)	T: ISP domain	F: F_UNCLASSIFIED	ECOD (1.6)
K [auth R]	PF00355	e6xkwR1	A: few secondary structure elements	X: Trm112p-like (From Topology)	H: Trm112p-like (From Topology)	T: Trm112p-like	F: PF00355	ECOD (1.6)
K [auth R]	PF10399	e6xkwR2	A: extended segments	X: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	H: iron-sulfur subunit (ISP) transmembrane anchor (From Topology)	T: iron-sulfur subunit (ISP) transmembrane anchor	F: PF10399	ECOD (1.6)
G [auth C]	PF00032	e6xkwC1	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF00032	ECOD (1.6)
G [auth C]	PF00033	e6xkwC2	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: PF00033	ECOD (1.6)
I [auth P]	PF00032	e6xkwP2	A: alpha bundles	X: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	H: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase) (From Topology)	T: a domain/subunit of cytochrome bc1 complex (Ubiquinol-cytochrome c reductase)	F: PF00032	ECOD (1.6)
I [auth P]	PF00033	e6xkwP1	A: alpha bundles	X: Transmembrane heme-binding four-helical bundle (From Homology)	H: Transmembrane heme-binding four-helical bundle	T: Transmembrane di-heme cytochromes	F: PF00033	ECOD (1.6)
H [auth D]	PF02167	e6xkwD1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF02167	ECOD (1.6)
J [auth Q]	PF02167	e6xkwQ1	A: alpha arrays	X: Cytochrome c-like	H: Cytochrome c (From Topology)	T: Cytochrome c	F: PF02167	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth n]	PF00115	Cytochrome C and Quinol oxidase polypeptide I (COX1)	Cytochrome C and Quinol oxidase polypeptide I	-	Family
B [auth o]	PF02433	Cytochrome C oxidase, mono-heme subunit/FixO (FixO)	Cytochrome C oxidase, mono-heme subunit/FixO	-	Family
C [auth p]	PF13442	Cytochrome C oxidase, cbb3-type, subunit III (Cytochrome_CBB3)	Cytochrome C oxidase, cbb3-type, subunit III	-	Domain
C [auth p]	PF00034	Cytochrome c (Cytochrom_C)	Cytochrome c	The Pfam entry does not include all Prosite members. The cytochrome 556 and cytochrome c' families are not included. All these are now in a new clan together. The C-terminus of DUF989, Pfam:PF06181, has now been merged into this family.	Domain
D [auth h]	PF05751	FixH (FixH)	FixH	-	Family
F [auth E], K [auth R]	PF10399	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal (UCR_Fe-S_N)	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal	-	Motif
F [auth E], K [auth R]	PF00355	Rieske [2Fe-2S] domain (Rieske)	Rieske [2Fe-2S] domain	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in ...	The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].	Domain
G [auth C], I [auth P]	PF00032	Cytochrome b(C-terminal)/b6/petD (Cytochrom_B_C)	Cytochrome b(C-terminal)/b6/petD	-	Domain
G [auth C], I [auth P]	PF00033	Cytochrome b/b6/petB (Cytochrome_B)	Cytochrome b/b6/petB	-	Domain
H [auth D], J [auth Q]	PF02167	Cytochrome C1 family (Cytochrom_C1)	Cytochrome C1 family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth n]	Cytochrome c oxidase, Cbb3-type, subunit I	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity primary active transmembrane transporter activity cytochrome-c oxidase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreductase activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity oxidoreductase activity, acting on a heme group of donors inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity catalytic activity binding organic cyclic compound binding tetrapyrrole binding heme binding cation binding ion binding metal ion binding small molecule binding	aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process metabolic process cellular process generation of precursor metabolites and energy	respiratory chain complex protein-containing complex cytochrome complex catalytic complex plasma membrane protein complex plasma membrane respirasome membrane plasma membrane membrane protein complex cellular anatomical entity respiratory chain complex IV cell periphery plasma membrane respiratory chain complex IV respirasome
B [auth o]	Cytochrome c oxidase, Cbb3-type, subunit II	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	-	membrane cellular anatomical entity
C [auth p]	Cbb3-type cytochrome c oxidase subunit CcoP	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport aerobic respiration cellular respiration oxidative phosphorylation energy derivation by oxidation of organic compounds cellular metabolic process metabolic process generation of precursor metabolites and energy	cell periphery plasma membrane membrane cellular anatomical entity respirasome
D [auth h]	Cytochrome c oxidase, Cbb3-type, biogenesis protein CcoH	-	-	-
E [auth Y]	Cytochrome c-type cyt cy	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	photosynthesis cellular metabolic process metabolic process cellular process	cell periphery plasma membrane membrane cellular anatomical entity
F [auth E], K [auth R]	Ubiquinol-cytochrome c reductase iron-sulfur subunit	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding binding metal cluster binding small molecule binding cation binding ion binding metal ion binding	-	cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle intracellular membrane-bounded organelle cytoplasm
G [auth C], I [auth P]	Cytochrome b	monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity monoatomic cation transmembrane transporter activity proton transmembrane transporter activity oxidoreductase activity, acting on diphenols and related substances as donors primary active transmembrane transporter activity oxidoreductase activity electron transfer activity active monoatomic ion transmembrane transporter activity oxidoreduction-driven active transmembrane transporter activity active transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity transporter activity ubiquinol-cytochrome-c reductase activity catalytic activity transmembrane transporter activity cation binding ion binding binding metal ion binding small molecule binding	cellular respiration energy derivation by oxidation of organic compounds respiratory electron transport chain cellular metabolic process electron transport chain metabolic process cellular process generation of precursor metabolites and energy	respiratory chain complex protein-containing complex catalytic complex cytochrome complex membrane membrane protein complex cellular anatomical entity transporter complex respiratory chain complex III transmembrane transporter complex respirasome oxidoreductase complex cell periphery plasma membrane
H [auth D], J [auth Q]	Cytochrome c1	binding organic cyclic compound binding tetrapyrrole binding heme binding electron transfer activity cation binding ion binding metal ion binding small molecule binding	-	cell periphery plasma membrane membrane cellular anatomical entity respirasome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth n]	IPR036927	Cytochrome c oxidase-like, subunit I superfamily	Homologous Superfamily
A [auth n]	IPR000883	Cytochrome c oxidase subunit I	Family
A [auth n]	IPR004677	Cytochrome c oxidase cbb3-type, subunit I	Family
A [auth n]	IPR023615	Cytochrome c oxidase, subunit I, copper-binding site	Binding Site
A [auth n]	IPR023616	Cytochrome c oxidase-like, subunit I domain	Domain
B [auth o]	IPR003468	Cytochrome c oxidase, monohaem subunit/FixO	Family
B [auth o]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
B [auth o]	IPR009056	Cytochrome c-like domain	Domain
C [auth p]	IPR004678	Cytochrome c oxidase cbb3-type, subunit III	Family
C [auth p]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
C [auth p]	IPR009056	Cytochrome c-like domain	Domain
C [auth p]	IPR032858	Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal	Domain
C [auth p]	IPR038414	Cbb3-type cytochrome c oxidase subunit CcoP, N-terminal domain superfamily	Homologous Superfamily
D [auth h]	IPR008620	Nitrogen fixation protein FixH	Family
D [auth h]	IPR018037	Nitrogen fixation protein FixH, Proteobacterial	Family
E [auth Y]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
E [auth Y]	IPR009056	Cytochrome c-like domain	Domain
E [auth Y]	IPR002327	Cytochrome c, class IA/ IB	Family
F [auth E], K [auth R]	IPR036922	Rieske [2Fe-2S] iron-sulphur domain superfamily	Homologous Superfamily
F [auth E], K [auth R]	IPR006311	Twin-arginine translocation pathway, signal sequence	Conserved Site
F [auth E], K [auth R]	IPR014349	Rieske iron-sulphur protein	Family
F [auth E], K [auth R]	IPR019470	Ubiquitinol-cytochrome C reductase, Fe-S subunit, TAT signal	Domain
F [auth E], K [auth R]	IPR017941	Rieske [2Fe-2S] iron-sulphur domain	Domain
F [auth E], K [auth R]	IPR005805	Rieske iron-sulphur protein, C-terminal	Domain
F [auth E], K [auth R]	IPR006317	Ubiquinol-cytochrome c reductase, iron-sulphur subunit	Domain
F [auth E], K [auth R]	IPR019546	Twin-arginine translocation pathway, signal sequence, bacterial/archaeal	Conserved Site
G [auth C], I [auth P]	IPR036150	Cytochrome b/b6, C-terminal domain superfamily	Homologous Superfamily
G [auth C], I [auth P]	IPR027387	Cytochrome b/b6-like domain superfamily	Homologous Superfamily
G [auth C], I [auth P]	IPR048260	Cytochrome b/b6, C-terminal domain, eukaryotic/bacterial	Domain
G [auth C], I [auth P]	IPR016174	Di-haem cytochrome, transmembrane	Homologous Superfamily
G [auth C], I [auth P]	IPR005798	Cytochrome b/b6, C-terminal	Domain
G [auth C], I [auth P]	IPR048259	Cytochrome b/b6, N-terminal domain, eukaryotic/bacterial	Domain
G [auth C], I [auth P]	IPR030689	Cytochrome b	Family
G [auth C], I [auth P]	IPR005797	Cytochrome b/b6, N-terminal domain	Domain
H [auth D], J [auth Q]	IPR036909	Cytochrome c-like domain superfamily	Homologous Superfamily
H [auth D], J [auth Q]	IPR002326	Cytochrome c1	Family
H [auth D], J [auth Q]	IPR009056	Cytochrome c-like domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E] A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E], G [auth C], H [auth D], I [auth P], J [auth Q], K [auth R]	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex IV (cytochrome c oxidase)	Respiratory supercomplexes III-IV

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E] A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E], G [auth C], H [auth D], I [auth P], J [auth Q], K [auth R]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E] A [auth n], B [auth o], C [auth p], E [auth Y], F [auth E], G [auth C], H [auth D], I [auth P], J [auth Q], K [auth R]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Electron Transport Chain Supercomplexes (Respirasome)	Respiratory supercomplex III₂-IV. CIII₂