6XFM

Molecular structure of the core of amyloid-like fibrils formed by residues 111-214 of FUS

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	RNA-binding protein FUS	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding chromatin binding binding molecular condensate scaffold activity transcription coactivator activity mRNA 3'-UTR binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding chromatin binding binding molecular condensate scaffold activity transcription coactivator activity mRNA 3'-UTR binding RNA binding organic cyclic compound binding nucleic acid binding mRNA binding DNA binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding	organonitrogen compound metabolic process primary metabolic process amyloid fibril formation cellular component organization organic substance metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component organization or biogenesis supramolecular fiber organization regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process organonitrogen compound metabolic process primary metabolic process amyloid fibril formation cellular component organization organic substance metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process cellular component organization or biogenesis supramolecular fiber organization regulation of cellular process negative regulation of biological process positive regulation of macromolecule biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process post-transcriptional regulation of gene expression regulation of RNA metabolic process organic substance biosynthetic process negative regulation of nucleobase-containing compound metabolic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of biological quality RNA catabolic process mRNA stabilization mRNA catabolic process regulation of biological process cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of cellular biosynthetic process nucleobase-containing compound catabolic process organic cyclic compound metabolic process regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process nucleic acid catabolic process regulation of macromolecule biosynthetic process regulation of metabolic process negative regulation of RNA metabolic process catabolic process cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process macromolecule catabolic process negative regulation of mRNA metabolic process regulation of mRNA catabolic process positive regulation of biosynthetic process negative regulation of cellular process positive regulation of cellular process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of catabolic process biological regulation negative regulation of mRNA catabolic process negative regulation of RNA catabolic process regulation of macromolecule metabolic process regulation of catabolic process gene expression mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process organic cyclic compound catabolic process regulation of cellular biosynthetic process regulation of mRNA stability RNA stabilization negative regulation of biosynthetic process positive regulation of gene expression regulation of RNA stability regulation of mRNA metabolic process organic substance catabolic process positive regulation of cellular biosynthetic process RNA splicing RNA processing cellular response to stimulus regulation of DNA recombination response to stimulus regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination DNA metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus regulation of DNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process organic cyclic compound biosynthetic process regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly protein homooligomerization regulation of RNA splicing	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle cellular anatomical entity non-membrane-bounded organelle cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR034870	TAF15/EWS/TLS family	Family
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR036443	Zinc finger, RanBP2-type superfamily	Homologous Superfamily
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR000504	RNA recognition motif domain	Domain
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR012677	Nucleotide-binding alpha-beta plait domain superfamily	Homologous Superfamily
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR001876	Zinc finger, RanBP2-type	Domain
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	IPR035979	RNA-binding domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], A [auth 1], B [auth 2], C [auth 3], D [auth 4], E [auth 5], F [auth 6], G [auth 7], H [auth 8]	Pharos: P35637	amyotrophic lateral sclerosis myxoid liposarcoma amyotrophic lateral sclerosis type 6 tremor, hereditary essential, 4 neurodegenerative disease juvenile amyotrophic lateral sclerosis Ewing sarcoma large cell medulloblastoma malignant ependymoma osteosarcoma acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) plasma cell myeloma astrocytic tumor amyotrophic lateral sclerosis myxoid liposarcoma amyotrophic lateral sclerosis type 6 tremor, hereditary essential, 4 neurodegenerative disease juvenile amyotrophic lateral sclerosis Ewing sarcoma large cell medulloblastoma malignant ependymoma osteosarcoma acute myeloid leukemia pancreatic intraductal papillary-mucinous carcinoma AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder) plasma cell myeloma astrocytic tumor subependymal giant cell astrocytoma dementia Graves disease histiocytoma, Angiomatoid fibrous ovarian cancer adrenal cortex carcinoma pancreatic intraductal papillary-mucinous neoplasm psoriasis brain disease systemic lupus erythematosus essential tremor frontotemporal dementia with motor neuron disease Hashimoto thyroiditis lymphoplasmacytic lymphoma medulloblastoma oligodendroglioma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome cancer gastric carcinoma hepatocellular carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.