6X8Q

Crystal structure of 3D11 Fab in complex with Plasmodium berghei circumsporozoite protein PAPP peptide

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	PF07654	e6x8qH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A [auth H]	PF07686	e6x8qH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B [auth L]	PF07654	e6x8qL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth L]	PF07686	e6x8qL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth H]	Fab 3D11, anti-PfCSP	VH-CH1	Chimeric (chimeric)	IGHV1-1201, IGHJ301, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG1*11	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)
B [auth L]	Fab 3D11, anti-PfCSP	L-KAPPA	Chimeric (chimeric)	IGKV1-13501, IGKJ101, IGKJ201, IGKC01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	FAB-GAMMA-1_KAPPA	IMGT (202416-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H]	Heavy Chain	IGHV1	-	papp peptide	SAbDab (2024-04-26)
B [auth L]	Light Chain	IGKV1	Kappa	papp peptide	SAbDab (2024-04-26)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H]	3D11 Fab heavy chain	-	-	-
B [auth L]	3D11 Fab light chain	-	-	-
C [auth P]	PAPP peptide	-	regulation of biological process biological process involved in interspecies interaction between organisms biological regulation positive regulation of biological process symbiont entry into host modulation by symbiont of entry into host positive regulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of biological process involved in symbiotic interaction symbiont entry into host cell viral process viral life cycle entry into host cell by a symbiont-containing vacuole regulation of biological process biological process involved in interspecies interaction between organisms biological regulation positive regulation of biological process symbiont entry into host modulation by symbiont of entry into host positive regulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of biological process involved in symbiotic interaction symbiont entry into host cell viral process viral life cycle entry into host cell by a symbiont-containing vacuole adhesion of symbiont to host cell adhesion of symbiont to host positive regulation of developmental process developmental process regulation of developmental process positive regulation of formation of structure involved in a symbiotic process modulation of formation of structure involved in a symbiotic process positive regulation of development of symbiont in host formation of structure involved in a symbiotic process regulation of development of symbiont in host development of symbiont in host	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth P]	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
C [auth P]	IPR003067	Plasmodium circumsporozoite protein	Family
C [auth P]	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.