Annotations: 6X4G

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF15910	e6x4gA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF15910	ECOD (1.6)
B [auth C]	PF07686	e6x4gC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B [auth C]	PF22705	e6x4gC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF22705	ECOD (1.6)
C [auth N]	PF07686	e6x4gN1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF15910	ICOS V-set domain (V-set_2)	ICOS V-set domain	This family contains divergent V-set ig domains found in the ICOS protein.	Domain
B [auth C]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Inducible T-cell costimulator	-	multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation multicellular organismal process regulation of cellular process regulation of leukocyte activation positive regulation of biological process regulation of cell activation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of cell activation cell adhesion cell-cell adhesion T cell activation positive regulation of leukocyte activation regulation of multicellular organismal process regulation of immune system process regulation of cell-cell adhesion positive regulation of immune system process positive regulation of cellular process regulation of biological process positive regulation of T cell activation positive regulation of cell adhesion regulation of cell adhesion cell activation biological regulation regulation of T cell activation immune system process lymphocyte costimulation regulation of leukocyte cell-cell adhesion positive regulation of multicellular organismal process cellular process T cell costimulation regulation of lymphocyte activation immune system development developmental process multicellular organism development T cell tolerance induction anatomical structure development tolerance induction system development response to stimulus immune response	cell periphery plasma membrane membrane cellular anatomical entity extracellular region
B [auth C]	ICOS ligand	protein binding binding signaling receptor binding identical protein binding	multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation regulation of cellular process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation multicellular organismal process T cell activation immune system process cell activation cellular process lymphocyte activation leukocyte activation regulation of cellular process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation regulation of biological process cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process regulation of activated T cell proliferation positive regulation of biological process positive regulation of leukocyte cell-cell adhesion leukocyte proliferation leukocyte cell-cell adhesion activated T cell proliferation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion positive regulation of cellular process T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion biological regulation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation cellular response to stimulus immune response-regulating cell surface receptor signaling pathway response to stimulus signaling cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response signal transduction cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response T cell receptor signaling pathway regulation of response to stimulus regulation of immune response antigen receptor-mediated signaling pathway activation of immune response adaptive immune response B cell activation cellular biosynthetic process organic substance metabolic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process defense response response to stress response to osmotic stress hyperosmotic response response to abiotic stimulus	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle
C [auth N]	anti ICOS-L VHH domain VNAR	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR039943	Inducible T-cell costimulator	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR013106	Immunoglobulin V-set domain	Domain
B [auth C]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B [auth C]	IPR003599	Immunoglobulin subtype	Domain
B [auth C]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B [auth C]	IPR013106	Immunoglobulin V-set domain	Domain
B [auth C]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9Y6W8	common variable immunodeficiency adult T-cell leukemia/lymphoma immunodeficiency, common variable, 1 alopecia areata psoriasis skin basal cell carcinoma Acquired Hypogammaglobulinemia agammaglobulinemia celiac disease Graves disease interstitial cystitis myasthenia gravis rheumatoid arthritis vitiligo acute T cell leukemia common variable immunodeficiency adult T-cell leukemia/lymphoma immunodeficiency, common variable, 1 alopecia areata psoriasis skin basal cell carcinoma Acquired Hypogammaglobulinemia agammaglobulinemia celiac disease Graves disease interstitial cystitis myasthenia gravis rheumatoid arthritis vitiligo acute T cell leukemia Hashimoto thyroiditis immunodeficiency, common variable, 2 lung cancer osteosarcoma Sjogren syndrome B cell deficiency cutaneous lupus erythematosus hypothyroidism lung carcinoma
B [auth C]	Pharos: O75144	ulcerative colitis celiac disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.