6X0V

Structure of MZT2/GCP-NHD and CDK5Rap2 at position 13 of the gamma-TuRC

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E]	PF12926	Mitotic-spindle organizing gamma-tubulin ring associated (MOZART2)	Mitotic-spindle organizing gamma-tubulin ring associated	-	Family
C [auth G], D [auth H]	PF07989	Centrosomin N-terminal motif 1 (Cnn_1N)	Centrosomin N-terminal motif 1	-	Coiled-coil

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E]	Mitotic-spindle organizing protein 2A	-	-	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex gamma-tubulin ring complex gamma-tubulin complex intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle intracellular anatomical structure cytoplasm cellular anatomical entity cytosol protein-containing complex gamma-tubulin ring complex gamma-tubulin complex intracellular organelle microtubule organizing center cytoskeleton organelle intracellular non-membrane-bounded organelle microtubule cytoskeleton non-membrane-bounded organelle spindle membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen centrosome
B [auth F]	Gamma-tubulin complex component 2	cytoskeletal protein binding protein binding binding gamma-tubulin binding tubulin binding	cellular process cell cycle mitotic cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular component organization cellular process cell cycle mitotic cell cycle developmental process multicellular organism development multicellular organismal process head development central nervous system development anatomical structure development animal organ development brain development nervous system development system development cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cytoplasmic microtubule organization cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly neuron migration cellular developmental process generation of neurons neurogenesis cell differentiation cell migration cell motility sexual reproduction reproductive process meiotic cell cycle organelle assembly non-membrane-bounded organelle assembly spindle assembly chromosome segregation spindle organization cell cycle process protein polymerization microtubule polymerization microtubule polymerization or depolymerization microtubule nucleation	intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane centrosome microtubule organizing center cytoplasm intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole cellular anatomical entity microtubule cytoskeleton non-membrane-bounded organelle membrane centrosome microtubule organizing center cytoplasm cytosol cell division site equatorial microtubule organizing center polymeric cytoskeletal fiber cytoplasmic microtubule supramolecular fiber microtubule supramolecular polymer supramolecular complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen protein-containing complex gamma-tubulin complex
C [auth G], D [auth H]	Centrosome protein Cep215	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding cytoskeletal protein binding protein binding tubulin binding gamma-tubulin binding microtubule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding cytoskeletal protein binding protein binding tubulin binding gamma-tubulin binding microtubule binding kinase binding enzyme binding protein kinase binding protein-containing complex binding calmodulin binding	multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process negative regulation of biological process regulation of cell differentiation neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development negative regulation of cellular process negative regulation of cell differentiation system development developmental process regulation of biological process negative regulation of developmental process biological regulation nervous system development generation of neurons cellular process negative regulation of neuron differentiation regulation of neuron differentiation head development central nervous system development animal organ development brain development cellular component organization microtubule bundle formation organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization cell cycle chromosome segregation cell cycle process cellular response to stimulus regulation of cell cycle phase transition response to stimulus spindle checkpoint signaling negative regulation of cell cycle regulation of signal transduction regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication regulation of cell cycle checkpoint negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction mitotic sister chromatid separation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling negative regulation of cellular component organization regulation of cell cycle process regulation of spindle checkpoint sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of response to stimulus regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic spindle checkpoint signaling regulation of mitotic cell cycle spindle assembly checkpoint spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle regulation of mitotic cell cycle regulation of intracellular signal transduction mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition regulation of cell cycle negative regulation of chromosome separation mitotic nuclear division regulation of signaling negative regulation of mitotic cell cycle phase transition organelle fission chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle regulation of cell communication metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition regulation of cytoskeleton organization negative regulation of centriole replication non-membrane-bounded organelle assembly negative regulation of organelle assembly cellular component biogenesis centrosome duplication negative regulation of centrosome cycle cellular component assembly centrosome cycle negative regulation of centrosome duplication regulation of centriole replication centriole replication centriole assembly microtubule organizing center organization organelle assembly negative regulation of cytoskeleton organization regulation of centrosome cycle regulation of microtubule-based process regulation of cellular component biogenesis regulation of centrosome duplication regulation of organelle assembly establishment of organelle localization cellular localization spindle localization establishment or maintenance of cell polarity localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell microtubule cytoskeleton organization involved in mitosis establishment of localization establishment of cell polarity establishment of mitotic spindle orientation positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of nucleobase-containing compound metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process positive regulation of RNA metabolic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process positive regulation of DNA-templated transcription cellular biosynthetic process positive regulation of biological process RNA metabolic process positive regulation of cellular metabolic process RNA biosynthetic process nucleic acid biosynthetic process organic substance metabolic process positive regulation of biosynthetic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process positive regulation of RNA biosynthetic process positive regulation of cellular biosynthetic process positive regulation of organelle organization regulation of microtubule polymerization or depolymerization positive regulation of cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly microtubule polymerization or depolymerization positive regulation of protein polymerization protein-containing complex assembly protein polymerization positive regulation of microtubule polymerization or depolymerization protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization microtubule polymerization positive regulation of supramolecular fiber organization positive regulation of microtubule polymerization regulation of protein polymerization regulation of microtubule polymerization regulation of supramolecular fiber organization supramolecular fiber organization regulation of microtubule cytoskeleton organization	cell junction cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle cell junction cellular anatomical entity intracellular organelle intracellular anatomical structure cytoskeleton spindle organelle intracellular non-membrane-bounded organelle spindle pole microtubule cytoskeleton non-membrane-bounded organelle extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle centrosome microtubule organizing center polymeric cytoskeletal fiber microtubule end supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule plus-end cytoplasm cytosol Golgi apparatus intracellular membrane-bounded organelle endomembrane system pericentriolar material perinuclear region of cytoplasm mitotic spindle mitotic spindle pole

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E]	IPR024332	MOZART2 family	Family
B [auth F]	IPR040457	Gamma tubulin complex component, C-terminal	Domain
B [auth F]	IPR042241	Gamma-tubulin complex component, C-terminal domain superfamily	Homologous Superfamily
B [auth F]	IPR007259	Gamma-tubulin complex component protein	Family
B [auth F]	IPR041470	Gamma tubulin complex component protein, N-terminal	Domain
C [auth G], D [auth H]	IPR042791	CDK5 regulatory subunit-associated protein 2	Family
C [auth G], D [auth H]	IPR012943	Centrosomin, N-terminal motif 1	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E]	Pharos: Q6P582	astrocytic tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia ovarian cancer pancreatic intraductal papillary-mucinous neoplasm
B [auth F]	Pharos: Q9BSJ2	epilepsy ovarian cancer Gaucher disease lissencephaly spectrum disorders
C [auth G], D [auth H]	Pharos: Q96SN8	microcephaly microcephaly 3, primary, autosomal recessive autosomal recessive primary microcephaly intellectual disability rheumatoid arthritis medulloblastoma myopathy pancreatic intraductal papillary-mucinous neoplasm corpus callosum, agenesis of osteosarcoma Primary microcephaly ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.