Annotations: 6WXR

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF03098	Animal haem peroxidase (An_peroxidase)	Animal haem peroxidase	-	Domain
A	PF08022	FAD-binding domain (FAD_binding_8)	FAD-binding domain	-	Domain
A	PF01794	Ferric reductase like transmembrane component (Ferric_reduct)	Ferric reductase like transmembrane component	-	Family
A	PF08030	Ferric reductase NAD binding domain (NAD_binding_6)	Ferric reductase NAD binding domain	-	Domain
B	PF10204	Dual oxidase maturation factor (DuoxA)	Dual oxidase maturation factor	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Dual oxidase 1	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity NAD(P)H oxidase H2O2-forming activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor cation binding ion binding binding calcium ion binding metal ion binding small molecule binding peroxidase activity oxidoreductase activity antioxidant activity oxidoreductase activity, acting on peroxide as acceptor catalytic activity NAD(P)H oxidase H2O2-forming activity oxidoreductase activity, acting on NAD(P)H oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor organic cyclic compound binding tetrapyrrole binding heme binding superoxide-generating NAD(P)H oxidase activity	superoxide metabolic process superoxide anion generation cellular metabolic process reactive oxygen species metabolic process metabolic process cellular process cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation superoxide metabolic process superoxide anion generation cellular metabolic process reactive oxygen species metabolic process metabolic process cellular process cellular response to stimulus response to organic substance regulation of biological process regulation of cellular process response to stimulus cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction organonitrogen compound metabolic process regulation of hormone levels organic hydroxy compound metabolic process hormone metabolic process cellular modified amino acid metabolic process thyroid hormone metabolic process organic cyclic compound metabolic process organic substance metabolic process phenol-containing compound metabolic process regulation of biological quality thyroid hormone generation biosynthetic process hormone biosynthetic process positive regulation of response to wounding wound healing positive regulation of biological process regulation of response to wounding positive regulation of response to stimulus positive regulation of wound healing regulation of response to stimulus response to stress regulation of response to stress regulation of wound healing response to wounding defense response reactive oxygen species biosynthetic process cellular biosynthetic process hydrogen peroxide metabolic process hydrogen peroxide biosynthetic process developmental process multicellular organism development multicellular organismal process cuticle development anatomical structure development response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to purine-containing compound response to cAMP response to organic cyclic compound positive regulation of locomotion regulation of cell motility regulation of locomotion positive regulation of cell motility cell motility positive regulation of cellular process locomotion response to oxidative stress	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane cell surface cell leading edge protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane cell surface cell leading edge protein-containing complex catalytic complex plasma membrane protein complex NADPH oxidase complex membrane protein complex oxidoreductase complex membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system
B	Dual oxidase maturation factor 1	-	cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis cellular metabolic process hydrogen peroxide metabolic process reactive oxygen species metabolic process metabolic process cellular process multicellular organismal process regulation of cellular process cellular developmental process regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of neuron differentiation positive regulation of developmental process neurogenesis multicellular organism development neuron differentiation positive regulation of cell differentiation cell differentiation anatomical structure development positive regulation of cellular process system development developmental process regulation of biological process biological regulation nervous system development generation of neurons regulation of neuron differentiation organonitrogen compound metabolic process regulation of hormone levels regulation of hormone metabolic process organic hydroxy compound metabolic process regulation of cellular metabolic process hormone metabolic process cellular modified amino acid metabolic process thyroid hormone metabolic process organic cyclic compound metabolic process organic substance metabolic process phenol-containing compound metabolic process regulation of biological quality regulation of metabolic process regulation of thyroid hormone generation thyroid hormone generation regulation of defense response response to stimulus regulation of response to external stimulus defense response regulation of inflammatory response response to external stimulus regulation of response to stimulus response to stress regulation of response to stress inflammatory response reactive oxygen species biosynthetic process cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of hydrogen peroxide metabolic process positive regulation of hydrogen peroxide metabolic process regulation of biosynthetic process regulation of hydrogen peroxide biosynthetic process positive regulation of reactive oxygen species biosynthetic process hydrogen peroxide biosynthetic process positive regulation of hydrogen peroxide biosynthetic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of cellular biosynthetic process biosynthetic process regulation of reactive oxygen species metabolic process positive regulation of cellular biosynthetic process protein localization establishment of protein localization cellular localization nitrogen compound transport transport organic substance transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization	cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cell periphery plasma membrane membrane cellular anatomical entity membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR019791	Haem peroxidase, animal-type	Family
A	IPR017938	Riboflavin synthase-like beta-barrel	Homologous Superfamily
A	IPR034821	Dual oxidase, peroxidase domain	Domain
A	IPR002048	EF-hand domain	Domain
A	IPR011992	EF-hand domain pair	Homologous Superfamily
A	IPR037120	Haem peroxidase domain superfamily, animal type	Homologous Superfamily
A	IPR013130	Ferric reductase transmembrane component-like domain	Domain
A	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A	IPR013112	FAD-binding 8	Domain
A	IPR039261	Ferredoxin-NADP reductase (FNR), nucleotide-binding domain	Homologous Superfamily
A	IPR010255	Haem peroxidase superfamily	Homologous Superfamily
A	IPR017927	FAD-binding domain, ferredoxin reductase-type	Domain
A	IPR013121	Ferric reductase, NAD binding domain	Domain
B	IPR018469	Dual oxidase maturation factor	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM	Transmembrane	Alpha-helical polytopic	Electron transport chain complex II superfamily	NADPH oxidase

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Oxidoreductases	DUOX1-DUOXA1 complex of the NADPH oxidase family in the absence of NADPH

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.