Annotations: 6WUC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D [auth W]	F_UNCLASSIFIED	e6wucW1	A: alpha arrays	X: Histone-like	H: Histone-related	T: Histone	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth H]	PF20993	CENPH protein (CENPH)	CENPH protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H]	Inner kinetochore subunit MCM16	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion mitotic cell cycle cellular component organization organelle organization mitotic cell cycle process establishment of sister chromatid cohesion cellular component organization or biogenesis cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
E [auth T]	Inner kinetochore subunit CNN1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding centromeric DNA binding nucleic acid binding protein-containing complex binding	negative regulation of kinetochore assembly regulation of cellular component organization regulation of cellular process regulation of centromere complex assembly non-membrane-bounded organelle assembly negative regulation of biological process negative regulation of organelle assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly negative regulation of chromosome organization cellular component assembly negative regulation of cellular process protein-containing complex assembly negative regulation of kinetochore assembly regulation of cellular component organization regulation of cellular process regulation of centromere complex assembly non-membrane-bounded organelle assembly negative regulation of biological process negative regulation of organelle assembly cellular component organization cellular component biogenesis protein-DNA complex organization regulation of protein-containing complex assembly negative regulation of chromosome organization cellular component assembly negative regulation of cellular process protein-containing complex assembly kinetochore organization cellular component organization or biogenesis regulation of biological process negative regulation of cellular component organization organelle assembly protein-containing complex organization biological regulation chromosome organization protein-DNA complex assembly regulation of chromosome organization regulation of kinetochore assembly regulation of cellular component biogenesis regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization kinetochore assembly regulation of organelle assembly cellular process centromere complex assembly cell division cell cycle chromosome segregation cell cycle process	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth I]	Inner kinetochore subunit CTF3	-	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus negative regulation of biological process spindle checkpoint signaling negative regulation of cell cycle regulation of mitotic nuclear division intracellular signal transduction negative regulation of mitotic cell cycle cell communication negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization negative regulation of cell cycle phase transition mitotic spindle checkpoint signaling signal transduction cell cycle mitotic sister chromatid separation chromosome segregation negative regulation of sister chromatid segregation mitotic spindle assembly checkpoint signaling regulation of biological process negative regulation of cellular component organization regulation of cell cycle process sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition regulation of mitotic sister chromatid segregation mitotic cell cycle process regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of cellular component organization regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle signaling spindle assembly checkpoint signaling cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle negative regulation of cellular process mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition cellular component organization or biogenesis regulation of cell cycle negative regulation of chromosome separation cell cycle process mitotic nuclear division negative regulation of mitotic cell cycle phase transition organelle fission biological regulation chromosome organization negative regulation of cell cycle process cell cycle checkpoint signaling mitotic cell cycle checkpoint signaling organelle organization nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell establishment of chromosome localization sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion sister chromatid cohesion establishment of sister chromatid cohesion cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
C [auth K]	Inner kinetochore subunit MCM22	-	establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation establishment of organelle localization cellular localization attachment of spindle microtubules to kinetochore establishment of localization metaphase chromosome alignment localization chromosome localization organelle localization establishment of localization in cell nuclear chromosome segregation cellular process cell cycle establishment of chromosome localization chromosome segregation cell cycle process sexual reproduction reproductive process meiotic cell cycle mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion mitotic cell cycle cellular component organization organelle organization mitotic cell cycle process establishment of sister chromatid cohesion cellular component organization or biogenesis cell division	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle
D [auth W]	Inner kinetochore subunit WIP1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding centromeric DNA binding nucleic acid binding	cellular process cell cycle chromosome segregation cell cycle process	intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure chromosome cellular anatomical entity chromosomal region kinetochore intracellular organelle organelle intracellular non-membrane-bounded organelle chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome non-membrane-bounded organelle membrane-bounded organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth H]	IPR048744	Inner kinetochore subunit MCM16	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.