6WSA

Crystal structure of a betaine aldehyde dehydrogenase from Burkholderia pseudomallei without cofactor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6wsaa1	Alpha and beta proteins (a/b)	ALDH-like	ALDH-like	automated matches	automated matches	(Burkholderia pseudomallei 1710b ) [TaxId: 320372 ],	SCOPe (2.08)
A	d6wsaa2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Burkholderia pseudomallei 1710b ) [TaxId: 320372 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	ALDH-like	8099403	4000806	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	ALDH-like	8099404	3001479	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Aldedh_2nd	e6wsaA1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_2nd	ECOD (1.6)
A	Aldedh_1st_1	e6wsaA2	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: Aldedh_1st_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.605.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 1	CATH (utative)
A	3.40.309.10	Alpha Beta	3-Layer(aba) Sandwich	Aldehyde Dehydrogenase	Chain A, domain 2	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NAD/NADP-dependent betaine aldehyde dehydrogenase	oxidoreductase activity aldehyde dehydrogenase (NAD+) activity betaine-aldehyde dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor cation binding ion binding binding metal ion binding small molecule binding	organonitrogen compound metabolic process amino-acid betaine biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process amino-acid betaine metabolic process cellular modified amino acid metabolic process glycine betaine metabolic process glycine betaine biosynthetic process from choline ammonium ion metabolic process organic substance metabolic process biosynthetic process cellular modified amino acid biosynthetic process choline metabolic process organic substance biosynthetic process organonitrogen compound metabolic process amino-acid betaine biosynthetic process cellular metabolic process organonitrogen compound biosynthetic process amino-acid betaine metabolic process cellular modified amino acid metabolic process glycine betaine metabolic process glycine betaine biosynthetic process from choline ammonium ion metabolic process organic substance metabolic process biosynthetic process cellular modified amino acid biosynthetic process choline metabolic process organic substance biosynthetic process metabolic process cellular process glycine betaine biosynthetic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR011264	Betaine aldehyde dehydrogenase	Family
A	IPR015590	Aldehyde dehydrogenase domain	Domain
A	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.