6WP9

AvaR1 bound to Avenolide

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00440	e6wp9A2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
A	PF21935	e6wp9A1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
B	PF00440	e6wp9B1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
B	PF21935	e6wp9B2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
C	PF00440	e6wp9C2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
C	PF21935	e6wp9C1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
D	PF00440	e6wp9D2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
D	PF21935	e6wp9D1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
E	PF00440	e6wp9E1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
E	PF21935	e6wp9E2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
F	PF00440	e6wp9F2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
F	PF21935	e6wp9F1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
G	PF00440	e6wp9G1	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
G	PF21935	e6wp9G2	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)
H	PF00440	e6wp9H2	A: alpha arrays	X: HTH	H: HTH	T: tri-helical	F: PF00440	ECOD (1.6)
H	PF21935	e6wp9H1	A: alpha bundles	X: Tetracyclin repressor-like, C-terminal domain (From Topology)	H: Tetracyclin repressor-like, C-terminal domain (From Topology)	T: Tetracyclin repressor-like, C-terminal domain	F: PF21935	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H	PF00440	Bacterial regulatory proteins, tetR family (TetR_N)	Bacterial regulatory proteins, tetR family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H	AvaR1	DNA binding binding organic cyclic compound binding nucleic acid binding	regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of cellular process cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process organic substance metabolic process organic substance biosynthetic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of biological process cellular metabolic process biological regulation primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process organic cyclic compound metabolic process regulation of gene expression biosynthetic process organic cyclic compound biosynthetic process metabolic process regulation of macromolecule biosynthetic process cellular process regulation of DNA-templated transcription macromolecule metabolic process regulation of metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H	IPR023772	DNA-binding HTH domain, TetR-type, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H	IPR047923	A-factor receptor protein-like	Family
A, B, C, D, E A, B, C, D, E, F, G, H	IPR001647	DNA-binding HTH domain, TetR-type	Domain
A, B, C, D, E A, B, C, D, E, F, G, H	IPR036271	Tetracyclin repressor-like, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H	IPR009057	Homeobox-like domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.