6WGG

Atomic model of pre-insertion mutant OCCM-DNA complex(ORC-Cdc6-Cdt1-Mcm2-7 with Mcm6 WHD truncation)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D [auth B]	SCOP2B Superfamily	Winged helix DNA-binding domain	8090224	3000034	SCOP2B (2022-06-29)
D [auth B]	SCOP2B Superfamily	RecA-like P-loop NTPases	8090226	3002019	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth 8]	F_UNCLASSIFIED	e6wgg82	A: beta sandwiches	X: jelly-roll	H: Double-stranded beta-helix (From Topology)	T: Double-stranded beta-helix	F: F_UNCLASSIFIED	ECOD (1.6)
A [auth 8]	F_UNCLASSIFIED	e6wgg81	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
K [auth 2]	PF17207	e6wgg22	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
K [auth 2]	PF17855	e6wgg21	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
K [auth 2]	PF14551	e6wgg23	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
K [auth 2]	PF00493	e6wgg25	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
K [auth 2]	F_UNCLASSIFIED	e6wgg24	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
L [auth 3]	PF17207	e6wgg34	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
L [auth 3]	F_UNCLASSIFIED	e6wgg36	A: alpha arrays	X: HTH	H: HTH	T: winged	F: F_UNCLASSIFIED	ECOD (1.6)
L [auth 3]	PF17855	e6wgg32	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
L [auth 3]	PF14551	e6wgg35	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
L [auth 3]	PF00493	e6wgg33	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
L [auth 3]	F_UNCLASSIFIED	e6wgg31	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
M [auth 4]	PF17207	e6wgg43	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
M [auth 4]	PF17855	e6wgg46	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
M [auth 4]	PF21128	e6wgg45	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21128	ECOD (1.6)
M [auth 4]	PF14551	e6wgg41	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
M [auth 4]	PF00493	e6wgg42	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
M [auth 4]	PF17207	e6wgg44	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
N [auth 5]	PF17207	e6wgg52	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
N [auth 5]	PF17855	e6wgg55	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
N [auth 5]	PF21933	e6wgg56	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF21933	ECOD (1.6)
N [auth 5]	PF14551	e6wgg53	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
N [auth 5]	PF00493	e6wgg54	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
N [auth 5]	F_UNCLASSIFIED	e6wgg51	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: F_UNCLASSIFIED	ECOD (1.6)
O [auth 6]	PF17207	e6wgg64	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: PF17207	ECOD (1.6)
O [auth 6]	PF17855	e6wgg63	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17855	ECOD (1.6)
O [auth 6]	PF14551	e6wgg62	A: a+b complex topology	X: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	H: N-terminal subdomain in DNA replication initiator (cdc21/cdc54) (From Topology)	T: N-terminal subdomain in DNA replication initiator (cdc21/cdc54)	F: PF14551	ECOD (1.6)
O [auth 6]	PF00493	e6wgg61	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00493	ECOD (1.6)
O [auth 6]	PF17207	e6wgg65	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: PF17207	ECOD (1.6)
B [auth 9]	PF09079	e6wgg92	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF09079	ECOD (1.6)
B [auth 9]	PF22606	e6wgg93	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF22606	ECOD (1.6)
B [auth 9]	PF13401	e6wgg91	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF13401	ECOD (1.6)
C [auth A]	PF21312	e6wggA2	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF21312	ECOD (1.6)
C [auth A]	PF17872	e6wggA3	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF17872	ECOD (1.6)
C [auth A]	PF00004	e6wggA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF00004	ECOD (1.6)
E [auth C]	PF18137	e6wggC3	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF18137	ECOD (1.6)
E [auth C]	PF07034	e6wggC2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF07034	ECOD (1.6)
E [auth C]	PF07034	e6wggC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: PF07034	ECOD (1.6)
G [auth D]	PF14629	e6wggD1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF14629	ECOD (1.6)
G [auth D]	PF14629	e6wggD2	A: alpha arrays	X: Histone-like	H: Histone-related	T: AAA+ ATPase lid domain	F: PF14629	ECOD (1.6)
G [auth D]	F_UNCLASSIFIED	e6wggD3	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
K [auth 2]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
K [auth 2]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
K [auth 2]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
L [auth 3]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
L [auth 3]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
M [auth 4]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
M [auth 4]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
M [auth 4]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
M [auth 4]	PF21128	MCM4, winged helix domain (MCM4_WHD)	MCM4, winged helix domain	DNA replication licensing factor MCM4 is a component of the MCM2-MCM7 complex which consists of six sequence-related AAA+ type ATPases/helicases that form a heterohexameric ring essential for 'once per cell cycle' DNA replication initiation and elon ...	DNA replication licensing factor MCM4 is a component of the MCM2-MCM7 complex which consists of six sequence-related AAA+ type ATPases/helicases that form a heterohexameric ring essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells [1-3]. This is the winged helix domain (WHD) found at the C-terminal of MCM4 [1-3]. Upon ssDNA binding the MCM5-WHD moves out of the central channel and becomes disordered, the MCM6-WHD moves backward and away from the channel, and the MCM4-WHD now partially occludes the channel opening. These changes enable CMG (Cdc45, Mcm2-7, GINS, the eukaryotic replicative helicase) to encircle dsDNA, and is consistent with reports that showed the MCM2-7 matures into two fully assembled CMGs on dsDNA before origin DNA unwinding occurs [3].	Domain
N [auth 5]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
O [auth 6]	PF14551	MCM N-terminal domain (MCM_N)	MCM N-terminal domain	This family contains the N-terminal domain of MCM proteins.	Domain
O [auth 6]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
O [auth 6]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
O [auth 6]	PF17207	MCM OB domain (MCM_OB)	MCM OB domain	This family contains an OB-fold found within MCM proteins. This domain contains an insertion at the zinc binding motif [2].	Domain
P [auth 7]	PF00493	MCM P-loop domain (MCM)	MCM P-loop domain	-	Domain
P [auth 7]	PF17855	MCM AAA-lid domain (MCM_lid)	MCM AAA-lid domain	This entry represents the AAA-lid domain found in MCM proteins.	Domain
B [auth 9]	PF13401	AAA domain (AAA_22)	AAA domain	-	Domain
C [auth A]	PF21312	Origin recognition complex subunit 1 C-terminal winged HTH domain (ORC1_wHTH)	Origin recognition complex subunit 1 C-terminal winged HTH domain	This entry represents the C-terminal winged helix-turn-helix domain found in the Origin recognition complex subunit 1 protein [1].	Domain
C [auth A]	PF00004	ATPase family associated with various cellular activities (AAA) (AAA)	ATPase family associated with various cellular activities (AAA)	AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes [2].	Domain
D [auth B]	PF04084	Origin recognition complex subunit 2 (ORC2)	Origin recognition complex subunit 2	-	Family
E [auth C]	PF18137	Origin recognition complex winged helix C-terminal (ORC_WH_C)	Origin recognition complex winged helix C-terminal	This is the C-terminal winged-helix (WH) DNA-binding domain of the origin recognition complex present in Drosophila melanogaster. The WH domain is responsible for recognizing origin sequences [1].	Domain
F [auth E]	PF13191	AAA ATPase domain (AAA_16)	AAA ATPase domain	This family of domains contain a P-loop motif that is characteristic of the AAA superfamily.	Domain
F [auth E]	PF14630	Origin recognition complex (ORC) subunit 5 C-terminus (ORC5_C)	Origin recognition complex (ORC) subunit 5 C-terminus	This entry represents the C-terminus of origin recognition complex subunit 5 [1,2], which consists of a winged helix domain (WHD).	Domain
F [auth E]	PF21639	ORC5, lid domain (ORC5_lid)	ORC5, lid domain	ORC5 is a component of the origin recognition complex (ORC) that binds origins of replication. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. This is the lid domain, which with the N-terminal RecA-fold ...	ORC5 is a component of the origin recognition complex (ORC) that binds origins of replication. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. This is the lid domain, which with the N-terminal RecA-fold domain, constitutes the well-known AAA+ domain [1].	Domain
G [auth D]	PF14629	Origin recognition complex (ORC) subunit 4 C-terminus (ORC4_C)	Origin recognition complex (ORC) subunit 4 C-terminus	-	Family
H [auth F]	PF05460	Origin recognition complex subunit 6 (ORC6) (ORC6)	Origin recognition complex subunit 6 (ORC6)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 8]	Cell division cycle protein CDT1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA-templated DNA replication protein-containing complex organization primary metabolic process pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process cell division regulation of DNA-templated DNA replication initiation regulation of biological process DNA replication initiation biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle protein-containing complex protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen pre-replicative complex intracellular organelle nucleoplasm intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle protein-containing complex protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen pre-replicative complex intracellular organelle nucleoplasm organelle lumen organelle nuclear pre-replicative complex nuclear lumen
J [auth H]	DNA (41-MER)	-	-	-
K [auth 2]	DNA replication licensing factor MCM2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides cation binding metal ion binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process DNA-templated DNA replication sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process meiotic cell cycle process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process premeiotic DNA replication metabolic process macromolecule metabolic process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly double-strand break repair DNA recombination double-strand break repair via break-induced replication recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication DNA replication initiation cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
L [auth 3]	DNA replication licensing factor MCM3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding MCM complex binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
M [auth 4]	DNA replication licensing factor MCM4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides single-stranded DNA binding	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication mitotic DNA replication cell cycle DNA replication initiation mitotic DNA replication initiation mitotic cell cycle nuclear cell cycle DNA replication initiation mitotic cell cycle process DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
N [auth 5]	Minichromosome maintenance protein 5	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein-containing complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of DNA-templated DNA replication initiation regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process chromosome organization regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
O [auth 6]	DNA replication licensing factor MCM6	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity single-stranded DNA binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process sexual reproduction reproductive process meiotic cell cycle nuclear DNA replication cell cycle DNA replication meiotic cell cycle process premeiotic DNA replication cellular process cell cycle cell cycle process pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair mitotic DNA replication mitotic cell cycle mitotic cell cycle process DNA strand elongation DNA strand elongation involved in DNA replication DNA duplex unwinding DNA geometric change chromosome organization DNA conformation change DNA unwinding involved in DNA replication organelle organization	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex
P [auth 7]	DNA replication licensing factor MCM7	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding MCM complex binding chromatin binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity ATP-dependent activity, acting on DNA DNA helicase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid single-stranded DNA helicase activity helicase activity	DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle DNA-templated DNA replication nuclear DNA replication cell cycle DNA replication primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process cellular process macromolecule metabolic process cell cycle cell cycle process DNA replication initiation sexual reproduction reproductive process meiotic cell cycle meiotic cell cycle process premeiotic DNA replication pre-replicative complex assembly cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination double-strand break repair via break-induced replication cellular response to stress DNA damage response response to stress recombinational repair double-strand break repair via homologous recombination DNA repair DNA strand elongation DNA strand elongation involved in DNA replication subtelomeric heterochromatin formation telomere organization chromosome organization organelle organization DNA duplex unwinding DNA geometric change DNA conformation change DNA unwinding involved in DNA replication	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle intracellular non-membrane-bounded organelle CMG complex nuclear lumen non-membrane-bounded organelle MCM core complex replication fork protection complex nuclear replication fork replication fork cytoplasm MCM complex pre-replicative complex nuclear pre-replicative complex chromosome, telomeric region chromosomal region
B [auth 9]	Cell division control protein 6	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding GTPase activity	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process mitotic DNA replication checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition cellular process negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process G1/S transition of mitotic cell cycle cell cycle G1/S phase transition cell division pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly regulation of DNA-templated DNA replication initiation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of DNA-templated DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular non-membrane-bounded organelle chromosome non-membrane-bounded organelle cytoplasm pre-replicative complex nuclear pre-replicative complex
C [auth A]	Origin recognition complex subunit 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity cation binding metal ion binding nucleosome binding	cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle cellular response to stimulus regulation of cellular process regulation of cell cycle phase transition response to stimulus signaling G2/M transition of mitotic cell cycle negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction mitotic cell cycle negative regulation of mitotic cell cycle cell communication mitotic G2/M transition checkpoint regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle DNA replication checkpoint signaling regulation of cell cycle cell cycle process cell cycle G2/M phase transition regulation of biological process mitotic DNA replication checkpoint signaling negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process biological regulation DNA integrity checkpoint signaling regulation of cell cycle G2/M phase transition negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic cell cycle process negative regulation of cell cycle G2/M phase transition cellular process negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process chromosome organization maintenance of DNA repeat elements cellular component organization maintenance of rDNA organelle organization cellular component organization or biogenesis pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular biosynthetic process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
D [auth B]	Origin recognition complex subunit 2	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process subtelomeric heterochromatin formation regulation of cellular process cellular biosynthetic process negative regulation of biological process telomere organization negative regulation of cellular metabolic process cellular component organization protein-DNA complex organization chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling cellular component organization or biogenesis negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation protein-containing complex organization epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation chromosome organization regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression organelle organization negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process cellular process negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component biogenesis cellular component assembly protein-containing complex assembly cell cycle cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly silent mating-type cassette heterochromatin formation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen intracellular non-membrane-bounded organelle chromosome chromosome, telomeric region chromosomal region non-membrane-bounded organelle pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome origin recognition complex
E [auth C]	Origin recognition complex subunit 3	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding protein-containing complex binding chromatin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
F [auth E]	Origin recognition complex subunit 5	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding nucleic acid binding DNA replication origin binding	DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of biological process biological regulation regulation of macromolecule metabolic process DNA-templated DNA replication DNA replication initiation primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process DNA replication organic substance metabolic process metabolic process macromolecule metabolic process regulation of biological process biological regulation regulation of macromolecule metabolic process regulation of primary metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication cellular component organization cellular component biogenesis protein-DNA complex organization cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication protein-containing complex organization pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly cellular process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process regulation of cellular metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex Cul8-RING ubiquitin ligase complex cullin-RING ubiquitin ligase complex ubiquitin ligase complex catalytic complex transferase complex intracellular protein-containing complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
G [auth D]	Origin recognition complex subunit 4	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA-templated DNA replication protein-containing complex organization primary metabolic process pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process DNA replication initiation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
H [auth F]	Origin recognition complex subunit 6	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding double-stranded DNA binding binding organic cyclic compound binding nucleic acid binding DNA replication origin binding	pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication pre-replicative complex assembly nuclear DNA replication cell cycle DNA replication nucleobase-containing compound metabolic process cellular component organization cellular component biogenesis protein-DNA complex organization organic substance metabolic process cellular component assembly protein-containing complex assembly cell cycle cellular component organization or biogenesis cell cycle process pre-replicative complex assembly involved in nuclear cell cycle DNA replication DNA-templated DNA replication protein-containing complex organization primary metabolic process pre-replicative complex assembly involved in cell cycle DNA replication protein-DNA complex assembly DNA metabolic process nucleic acid metabolic process organic cyclic compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process regulation of cellular process cellular biosynthetic process negative regulation of biological process negative regulation of cellular metabolic process chromatin organization organic substance biosynthetic process negative regulation of cellular process chromatin remodeling negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process heterochromatin formation epigenetic regulation of gene expression cellular metabolic process negative regulation of metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process regulation of gene expression negative regulation of gene expression constitutive heterochromatin formation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process silent mating-type cassette heterochromatin formation negative regulation of gene expression, epigenetic regulation of macromolecule biosynthetic process regulation of metabolic process DNA replication initiation	membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen membrane-bounded organelle DNA replication preinitiation complex protein-containing complex intracellular anatomical structure protein-DNA complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle cellular anatomical entity intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen pre-replicative complex nuclear pre-replicative complex nuclear origin of replication recognition complex nuclear chromosome chromosome origin recognition complex intracellular non-membrane-bounded organelle non-membrane-bounded organelle
I [auth G]	DNA (41-MER)	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth 8]	IPR032054	DNA replication factor Cdt1, C-terminal	Domain
A [auth 8]	IPR038090	DNA replication factor Cdt1, C-terminal WH domain superfamily	Homologous Superfamily
K [auth 2]	IPR031327	Mini-chromosome maintenance protein	Family
K [auth 2]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
K [auth 2]	IPR001208	MCM domain	Domain
K [auth 2]	IPR041562	MCM, AAA-lid domain	Domain
K [auth 2]	IPR008045	DNA replication licensing factor Mcm2	Family
K [auth 2]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
K [auth 2]	IPR027925	MCM, N-terminal domain	Domain
K [auth 2]	IPR033762	MCM OB domain	Domain
K [auth 2]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
L [auth 3]	IPR031327	Mini-chromosome maintenance protein	Family
L [auth 3]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
L [auth 3]	IPR003593	AAA+ ATPase domain	Domain
L [auth 3]	IPR001208	MCM domain	Domain
L [auth 3]	IPR041562	MCM, AAA-lid domain	Domain
L [auth 3]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
L [auth 3]	IPR027925	MCM, N-terminal domain	Domain
L [auth 3]	IPR008046	DNA replication licensing factor Mcm3	Family
L [auth 3]	IPR033762	MCM OB domain	Domain
L [auth 3]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
M [auth 4]	IPR031327	Mini-chromosome maintenance protein	Family
M [auth 4]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
M [auth 4]	IPR001208	MCM domain	Domain
M [auth 4]	IPR041562	MCM, AAA-lid domain	Domain
M [auth 4]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
M [auth 4]	IPR027925	MCM, N-terminal domain	Domain
M [auth 4]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
M [auth 4]	IPR008047	Mini-chromosome maintenance complex protein 4	Family
M [auth 4]	IPR033762	MCM OB domain	Domain
M [auth 4]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
N [auth 5]	IPR031327	Mini-chromosome maintenance protein	Family
N [auth 5]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
N [auth 5]	IPR001208	MCM domain	Domain
N [auth 5]	IPR041562	MCM, AAA-lid domain	Domain
N [auth 5]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
N [auth 5]	IPR027925	MCM, N-terminal domain	Domain
N [auth 5]	IPR033762	MCM OB domain	Domain
N [auth 5]	IPR008048	DNA replication licensing factor Mcm5	Family
N [auth 5]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
O [auth 6]	IPR008049	DNA replication licensing factor Mcm6	Family
O [auth 6]	IPR041024	Mcm6, C-terminal winged-helix domain	Domain
O [auth 6]	IPR031327	Mini-chromosome maintenance protein	Family
O [auth 6]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
O [auth 6]	IPR001208	MCM domain	Domain
O [auth 6]	IPR041562	MCM, AAA-lid domain	Domain
O [auth 6]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
O [auth 6]	IPR027925	MCM, N-terminal domain	Domain
O [auth 6]	IPR033762	MCM OB domain	Domain
O [auth 6]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
P [auth 7]	IPR031327	Mini-chromosome maintenance protein	Family
P [auth 7]	IPR008050	DNA replication licensing factor Mcm7	Family
P [auth 7]	IPR018525	Mini-chromosome maintenance, conserved site	Conserved Site
P [auth 7]	IPR003593	AAA+ ATPase domain	Domain
P [auth 7]	IPR001208	MCM domain	Domain
P [auth 7]	IPR041562	MCM, AAA-lid domain	Domain
P [auth 7]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
P [auth 7]	IPR027925	MCM, N-terminal domain	Domain
P [auth 7]	IPR033762	MCM OB domain	Domain
P [auth 7]	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
B [auth 9]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
B [auth 9]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B [auth 9]	IPR003593	AAA+ ATPase domain	Domain
B [auth 9]	IPR016314	Cell division protein Cdc6/18	Family
B [auth 9]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth A]	IPR041083	AAA lid domain	Domain
C [auth A]	IPR043151	Bromo adjacent homology (BAH) domain superfamily	Homologous Superfamily
C [auth A]	IPR048867	Origin recognition complex subunit 1, C-terminal winged HTH domain	Domain
C [auth A]	IPR001025	Bromo adjacent homology (BAH) domain	Domain
C [auth A]	IPR003593	AAA+ ATPase domain	Domain
C [auth A]	IPR003959	ATPase, AAA-type, core	Domain
C [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth B]	IPR007220	Origin recognition complex, subunit 2	Family
E [auth C]	IPR020795	Origin recognition complex, subunit 3	Family
E [auth C]	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
E [auth C]	IPR040855	Origin recognition complex subunit 3, winged helix C-terminal	Domain
F [auth E]	IPR048866	ORC5, lid domain	Domain
F [auth E]	IPR047088	Origin recognition complex subunit 5, C-terminal	Domain
F [auth E]	IPR041664	Orc1-like, AAA ATPase domain	Domain
F [auth E]	IPR020796	Origin recognition complex, subunit 5	Family
F [auth E]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G [auth D]	IPR032705	Origin recognition complex subunit 4, C-terminal	Domain
G [auth D]	IPR016527	Origin recognition complex subunit 4	Family
G [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
H [auth F]	IPR016811	Origin recognition complex, subunit 6, fungi	Family
H [auth F]	IPR008721	Origin recognition complex, subunit 6	Family