6WFW

Crystal structure of Fab364 in complex with NPNA2 peptide from circumsporozoite protein

External Resource: Annotation

Domain Annotation: ECOD Classification
IMGT Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth G]	PF01378	e6wfwG1	A: a+b two layers	X: beta-Grasp	H: Immunoglobulin-binding domains (From Topology)	T: Immunoglobulin-binding domains	F: PF01378	ECOD (1.6)
B [auth H]	PF07654	e6wfwH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth H]	PF07686	e6wfwH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C [auth L]	PF07654	e6wfwL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
C [auth L]	PF07686	e6wfwL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth G]	-	LINKER	-	-	-	TR	(LINKER)	IMGT (202416-0)
B [auth H]	IMMUNOGLOBULIN G-BINDING PROTEIN G,H	(VH-LINKER-CH1)	-	IGHV3-3303, IGHV3-3306, IGHJ401, IGHJ402, IGHJ403, IGHJ501, IGHJ801, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG111	V-DOMAIN VH, C-DOMAIN CH1	IG	(L-KAPPA_VH-LINKER-CH1)	IMGT (202416-0)
C [auth L]	IMMUNOGLOBULIN G-BINDING PROTEIN G,H	L-KAPPA	-	IGKV1-503, IGKJ101, IGKC*01	V-DOMAIN V-KAPPA, C-DOMAIN C-KAPPA	IG	(L-KAPPA_VH-LINKER-CH1)	IMGT (202416-0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth G]	PF01378	B domain (IgG_binding_B)	B domain	This domain is found as a tandem repeat in Streptococcal cell surface proteins, such as the IgG binding protein G.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G]	Immunoglobulin G-binding protein G	protein-containing complex binding binding immunoglobulin binding IgG binding	-	extracellular region cellular anatomical entity
B [auth H]	Fab364 heavy chain	-	-	-
C [auth L]	Fab364 light chain	-	-	-
D [auth P]	NPNA2 peptide	-	biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle entry into host cell by a symbiont-containing vacuole biological process involved in interaction with host biological process involved in symbiotic interaction	cell surface cellular anatomical entity membrane side of membrane cell periphery plasma membrane intracellular anatomical structure cytoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G]	IPR009063	Immunoglobulin/albumin-binding domain superfamily	Homologous Superfamily
A [auth G]	IPR019950	M protein-type anchor domain	Domain
A [auth G]	IPR005877	YSIRK Gram-positive signal peptide	Domain
A [auth G]	IPR000724	IgG-binding B	Domain
A [auth G]	IPR035152	GA-like domain	Domain
A [auth G]	IPR019931	LPXTG cell wall anchor domain	Domain
D [auth P]	IPR000884	Thrombospondin type-1 (TSP1) repeat	Repeat
D [auth P]	IPR003067	Plasmodium circumsporozoite protein	Family
D [auth P]	IPR036383	Thrombospondin type-1 (TSP1) repeat superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.