Annotations: 6WC9

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF06736	e6wc9A1	A: alpha complex topology	X: Potassium channel TMEM175 (From Topology)	H: Potassium channel TMEM175 (From Topology)	T: Potassium channel TMEM175	F: PF06736	ECOD (1.6)
B	PF06736	e6wc9B1	A: alpha complex topology	X: Potassium channel TMEM175 (From Topology)	H: Potassium channel TMEM175 (From Topology)	T: Potassium channel TMEM175	F: PF06736	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF06736	Endosomal/lysosomal potassium channel TMEM175 (TMEM175)	Endosomal/lysosomal potassium channel TMEM175	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Endosomal/lysosomal potassium channel TMEM175	monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity monoatomic cation transmembrane transporter activity potassium ion transmembrane transporter activity monoatomic ion channel activity potassium ion leak channel activity potassium channel activity monoatomic cation channel activity passive transmembrane transporter activity narrow pore channel activity leak channel activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity channel activity monoatomic ion transmembrane transporter activity transporter activity metal ion transmembrane transporter activity transmembrane transporter activity proton transmembrane transporter activity proton channel activity fatty acid binding icosanoid binding organic acid binding binding arachidonic acid binding long-chain fatty acid binding icosatetraenoic acid binding ion binding anion binding lipid binding carboxylic acid binding small molecule binding monocarboxylic acid binding	transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport import into cell membrane fusion transport proton transmembrane transport monoatomic ion transmembrane transport inorganic ion transmembrane transport establishment of localization inorganic cation transmembrane transport transmembrane transport monoatomic cation transmembrane transport localization monoatomic ion transport cellular process monoatomic cation transport import into cell membrane fusion organelle membrane fusion vesicle-mediated transport vesicle organization cellular component organization cellular component biogenesis lysosome organization cellular component assembly phagolysosome assembly phagocytosis cellular component organization or biogenesis membrane organization vacuole organization organelle assembly lytic vacuole organization phagosome-lysosome fusion phagosome maturation organelle fusion organelle organization endocytosis vesicle fusion homeostatic process regulation of intracellular pH intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis regulation of biological quality monoatomic cation homeostasis regulation of cellular pH regulation of lysosomal lumen pH intracellular monoatomic ion homeostasis biological regulation lysosomal lumen pH elevation cellular homeostasis chemical homeostasis intracellular pH elevation potassium ion transmembrane transport metal ion transport potassium ion transport neuron cellular homeostasis	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane cytoplasm organelle membrane lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle endosome membrane cytoplasmic vesicle membrane vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR010617	Endosomal/lysosomal proton channel TMEM175-like	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9BSA9	Parkinson disease bone disease systemic lupus erythematosus myositis primary biliary cholangitis systemic sclerosis neurodegenerative disease rheumatoid arthritis

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B	OPM				Potassium channel TMEM175

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A, B	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Channels: Potassium, Sodium, & Proton Ion-Selective	TMEM175 lysosomal K⁺ channel, open state in KCl

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.