Annotations: 6WB9

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth 0]	PF21203	ER membrane protein complex subunit 10 (ECM10)	ER membrane protein complex subunit 10	-	Family
B [auth 1]	PF07774	ER membrane protein complex subunit 1, C-terminal (EMC1_C)	ER membrane protein complex subunit 1, C-terminal	This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the ...	This is the C-terminal domain of ER membrane protein complex subunit 1. ER membrane protein complex subunit 1 is a component of the ER membrane protein complex (EMC, composed of EMC1, EMC2, EMC3, EMC4, EMC5 and EMC6). In Saccharomyces cerevisiae, the EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER) [1].	Domain
F [auth 5]	PF10270	Membrane magnesium transporter (MMgT)	Membrane magnesium transporter	-	Family
G [auth 6]	PF07019	EMC6 (EMC6)	EMC6	-	Family
H [auth 7]	PF17081	Suppressor of PMA 1-7 protein (SOP4)	Suppressor of PMA 1-7 protein	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth 0]	Endoplasmic reticulum membrane protein complex subunit 10	-	protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization establishment of localization cellular component organization localization organelle organization protein localization to organelle cellular macromolecule localization macromolecule localization cellular process cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
B [auth 1]	ER membrane protein complex subunit 1	-	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
C [auth 2]	ER membrane protein complex subunit 2	-	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane nucleus
D [auth 3]	ER membrane protein complex subunit 3	protein binding binding protein-folding chaperone binding	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
E [auth 4]	ER membrane protein complex subunit 4	-	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
F [auth 5]	ER membrane protein complex subunit 5	-	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
G [auth 6]	ER membrane protein complex subunit 6	-	localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression localization transport macromolecule localization organic substance transport phospholipid transport lipid localization lipid transport establishment of localization organophosphate ester transport organonitrogen compound metabolic process cellular biosynthetic process cellular metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein maturation organic substance metabolic process protein folding biosynthetic process organic substance biosynthetic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein folding in endoplasmic reticulum phospholipid metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphorus metabolic process lipid metabolic process protein localization membrane organization cellular localization establishment of protein localization establishment of protein localization to membrane protein insertion into ER membrane by stop-transfer membrane-anchor sequence localization within membrane protein localization to membrane endoplasmic reticulum organization cellular component organization organelle organization protein localization to organelle cellular macromolecule localization cellular component organization or biogenesis protein insertion into membrane protein insertion into ER membrane endomembrane system organization autophagosome assembly catabolic process organelle assembly vacuole organization macroautophagy autophagy autophagosome organization cellular component biogenesis cellular catabolic process cellular component assembly process utilizing autophagic mechanism	membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network membrane-bounded organelle protein-containing complex intracellular anatomical structure EMC complex organelle subcompartment membrane membrane protein complex cellular anatomical entity intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane
H [auth 7]	Protein SOP4	-	localization cellular localization transport establishment of localization in cell intracellular transport cellular process endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport organic substance transport localization cellular localization transport establishment of localization in cell intracellular transport cellular process endoplasmic reticulum to Golgi vesicle-mediated transport establishment of localization Golgi vesicle transport vesicle-mediated transport protein localization establishment of protein localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization	membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane membrane cellular anatomical entity membrane-bounded organelle intracellular organelle intracellular anatomical structure organelle endoplasmic reticulum cytoplasm intracellular membrane-bounded organelle endomembrane system organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network organelle membrane endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
B [auth 1]	IPR011678	ER membrane protein complex subunit 1, C-terminal	Domain
B [auth 1]	IPR026895	ER membrane protein complex subunit 1	Family
C [auth 2]	IPR039856	ER membrane protein complex subunit 2-like	Family
C [auth 2]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
C [auth 2]	IPR019734	Tetratricopeptide repeat	Repeat
D [auth 3]	IPR008568	ER membrane protein complex subunit 3	Family
D [auth 3]	IPR002809	Integral membrane protein EMC3/TMCO1-like	Family
E [auth 4]	IPR009445	TMEM85/ER membrane protein complex subunit 4	Family
F [auth 5]	IPR018937	Membrane magnesium transporter	Family
G [auth 6]	IPR008504	ER membrane protein complex subunit 6	Family
G [auth 6]	IPR029008	ER membrane protein complex subunit 6-like	Family
H [auth 7]	IPR031395	Protein Sop4	Family

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4] A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4], F [auth 5], G [auth 6], H [auth 7]	OPM				ER membrane protein insertion complex

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4] A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4], F [auth 5], G [auth 6], H [auth 7]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4] A [auth 0], B [auth 1], C [auth 2], D [auth 3], E [auth 4], F [auth 5], G [auth 6], H [auth 7]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.