6WAA

K. pneumoniae Topoisomerase IV (ParE-ParC) in complex with DNA and compound 34 (7-[(1S,5R)-1-amino-3-azabicyclo[3.1.0]hexan-3-yl]-4-(aminomethyl)-1-cyclopropyl-3,6-difluoro-8-methylquinolin-2(1H)-one)

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	PF00521	e6waaB1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00521	ECOD (1.6)
A [auth B]	PF00521	e6waaB3	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
A [auth B]	PF00521	e6waaB2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
A [auth B]	PF00986,PF01751	e6waaB4	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: PF00986,PF01751	ECOD (1.6)
B [auth D]	PF00521	e6waaD4	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00521	ECOD (1.6)
B [auth D]	PF00521	e6waaD1	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
B [auth D]	PF00521	e6waaD2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
B [auth D]	PF00986,PF01751	e6waaD3	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: PF00986,PF01751	ECOD (1.6)
C [auth F]	PF00521	e6waaF1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00521	ECOD (1.6)
C [auth F]	PF00521	e6waaF3	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
C [auth F]	PF00521	e6waaF2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
C [auth F]	PF00986,PF01751	e6waaF4	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: PF00986,PF01751	ECOD (1.6)
D [auth H]	PF00521	e6waaH1	A: alpha arrays	X: HTH	H: HTH	T: winged	F: PF00521	ECOD (1.6)
D [auth H]	PF00521	e6waaH4	A: alpha bundles	X: alpha-helical domain in type II DNA topoisomerase (From Topology)	H: alpha-helical domain in type II DNA topoisomerase (From Topology)	T: alpha-helical domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
D [auth H]	PF00521	e6waaH2	A: a+b two layers	X: a+b domain in type II DNA topoisomerase (From Topology)	H: a+b domain in type II DNA topoisomerase (From Topology)	T: a+b domain in type II DNA topoisomerase	F: PF00521	ECOD (1.6)
D [auth H]	PF00986,PF01751	e6waaH3	A: a/b three-layered sandwiches	X: HAD domain-like	H: HAD domain-related	T: Toprim domain	F: PF00986,PF01751	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth D], C [auth F], D [auth H]	PF00521	DNA gyrase/topoisomerase IV, subunit A (DNA_topoisoIV)	DNA gyrase/topoisomerase IV, subunit A	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth D], C [auth F], D [auth H]	DNA topoisomerase 4 subunit B,DNA topoisomerase (ATP-hydrolyzing) chimera	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding ATP-dependent activity, acting on DNA isomerase activity catalytic activity, acting on DNA catalytic activity, acting on a nucleic acid DNA topoisomerase activity DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity catalytic activity ATP-dependent activity	cellular process cell cycle chromosome segregation cell cycle process chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process DNA topological change organic cyclic compound metabolic process organelle organization cellular process cell cycle chromosome segregation cell cycle process chromosome organization primary metabolic process DNA conformation change DNA metabolic process nucleic acid metabolic process cellular component organization nucleobase-containing compound metabolic process DNA topological change organic cyclic compound metabolic process organelle organization organic substance metabolic process metabolic process cellular component organization or biogenesis macromolecule metabolic process	intracellular organelle intracellular anatomical structure organelle intracellular non-membrane-bounded organelle chromosome cellular anatomical entity non-membrane-bounded organelle cell periphery extrinsic component of plasma membrane membrane plasma membrane extrinsic component of membrane
E [auth I], H [auth L], I [auth M], L [auth P]	DNA (5'-D(TPTPAPCPGPTPTPGPTPAP*T)-3')	-	-	-
F [auth J], G [auth K], J [auth N], K [auth O]	DNA (5'-D(GPAPTPCPAPTPAPCPAPAPCPGPTPAP*A)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth D], C [auth F], D [auth H]	IPR035516	DNA gyrase/topoisomerase IV, subunit A, C-terminal	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR013760	DNA topoisomerase, type IIA-like domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR013757	DNA topoisomerase, type IIA, alpha-helical domain superfamily	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR013758	DNA topoisomerase, type IIA, domain A, alpha-beta	Homologous Superfamily
A [auth B], B [auth D], C [auth F], D [auth H]	IPR005742	DNA topoisomerase IV, subunit A, Gram-negative	Family
A [auth B], B [auth D], C [auth F], D [auth H]	IPR006691	DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat	Repeat
A [auth B], B [auth D], C [auth F], D [auth H]	IPR002205	DNA topoisomerase, type IIA, domain A	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A [auth B], B [auth D], C [auth F], D [auth H]	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.