6W4E

NMR-driven structure of KRAS4B-GTP homodimer on a lipid bilayer nanodisc

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6w4ea1	Coiled coil proteins	Apolipoprotein A-I	Apolipoprotein A-I	Apolipoprotein A-I	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d6w4ea2	Artifacts	Tags	Tags	Tags	C-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth D]	d6w4ed_	Coiled coil proteins	Apolipoprotein A-I	Apolipoprotein A-I	Apolipoprotein A-I	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Apolipoprotein	8072930	3001489	SCOP2B (2022-06-29)
B [auth D]	SCOP2B Superfamily	Apolipoprotein	8072930	3001489	SCOP2B (2022-06-29)
C [auth B]	SCOP2B Superfamily	Ras-like P-loop GTPases	8060856	3002022	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Ras-like P-loop GTPases	8060856	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Apolipoprotein	e6w4eA1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Apolipoprotein (From Topology)	T: Apolipoprotein	F: Apolipoprotein	ECOD (1.6)
B [auth D]	Apolipoprotein	e6w4eD1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Apolipoprotein (From Topology)	T: Apolipoprotein	F: Apolipoprotein	ECOD (1.6)
C [auth B]	Ras	e6w4eB1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)
D [auth C]	Ras	e6w4eC1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
D [auth C]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth D]	PF01442	Apolipoprotein A1/A4/E domain (Apolipoprotein)	Apolipoprotein A1/A4/E domain	These proteins contain several 22 residue repeats which form a pair of alpha helices. This family includes: Swiss:P02647 Apolipoprotein A-I. Swiss:P06727 Apolipoprotein A-IV. Swiss:P02649 Apolipoprotein E.	Domain
C [auth B], D [auth C]	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth D]	Apolipoprotein A-I	amide binding amyloid-beta binding binding peptide binding high-density lipoprotein particle receptor binding protein binding signaling receptor binding lipoprotein particle receptor binding heat shock protein binding phospholipid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity amide binding amyloid-beta binding binding peptide binding high-density lipoprotein particle receptor binding protein binding signaling receptor binding lipoprotein particle receptor binding heat shock protein binding phospholipid binding lipid binding sterol transfer activity lipid transporter activity lipid transfer activity transporter activity cholesterol transfer activity apolipoprotein A-I receptor binding apolipoprotein receptor binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding high-density lipoprotein particle binding identical protein binding enzyme regulator activity enzyme activator activity molecular function activator activity molecular function regulator activity phosphatidylcholine-sterol O-acyltransferase activator activity sterol binding organic cyclic compound binding alcohol binding steroid binding cholesterol binding small molecule binding protein homodimerization activity protein dimerization activity signaling receptor regulator activity chemorepellent activity receptor ligand activity signaling receptor activator activity enzyme binding	positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process positive regulation of cholesterol efflux regulation of localization transport positive regulation of sterol transport positive regulation of biological process regulation of lipid transport organic hydroxy compound transport localization regulation of cholesterol efflux sterol transport regulation of cholesterol transport positive regulation of cholesterol transport regulation of sterol transport regulation of biological process regulation of transport organic substance transport biological regulation lipid localization lipid transport positive regulation of lipid localization establishment of localization positive regulation of lipid transport positive regulation of transport regulation of lipid localization macromolecule localization cholesterol transport cholesterol efflux vitamin transport regulation of protein stability regulation of biological quality protein stabilization phospholipid homeostasis chemical homeostasis homeostatic process lipid homeostasis reverse cholesterol transport regulation of CoA-transferase activity regulation of molecular function positive regulation of molecular function positive regulation of transferase activity regulation of catalytic activity positive regulation of CoA-transferase activity positive regulation of catalytic activity regulation of transferase activity triglyceride homeostasis acylglycerol homeostasis epithelium migration multicellular organismal process tissue migration endothelial cell migration ameboidal-type cell migration blood vessel endothelial cell migration epithelial cell migration cell migration cellular process cell motility organonitrogen compound metabolic process cellular metabolic process glycerophospholipid metabolic process primary metabolic process phospholipid metabolic process organic substance metabolic process organophosphate metabolic process cellular lipid metabolic process phosphate-containing compound metabolic process phosphatidylcholine metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process import into cell positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization vesicle-mediated transport cellular component organization positive regulation of endocytosis phagocytosis cellular component organization or biogenesis positive regulation of cellular process regulation of endocytosis regulation of phagocytosis regulation of vesicle-mediated transport positive regulation of phagocytosis endocytosis regulation of immune effector process response to stimulus negative regulation of biological process negative regulation of cellular metabolic process cytokine production organic substance biosynthetic process regulation of immune system process negative regulation of cytokine production involved in immune response regulation of cytokine production involved in immune response immune response negative regulation of metabolic process negative regulation of immune effector process regulation of cellular metabolic process negative regulation of cellular biosynthetic process immune effector process regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of production of molecular mediator of immune response negative regulation of multicellular organismal process regulation of metabolic process cellular biosynthetic process negative regulation of cellular process regulation of cytokine production regulation of multicellular organismal process cytokine production involved in immune response negative regulation of macromolecule metabolic process production of molecular mediator of immune response regulation of biosynthetic process negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process negative regulation of immune system process negative regulation of biosynthetic process immune system process positive regulation of substrate adhesion-dependent cell spreading regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of substrate adhesion-dependent cell spreading regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion substrate adhesion-dependent cell spreading embryo development negative regulation of cell adhesion regulation of cell-cell adhesion involved in gastrulation heterotypic cell-cell adhesion multicellular organism development cell-cell adhesion anatomical structure development regulation of cell-cell adhesion regulation of heterotypic cell-cell adhesion cell-cell adhesion via plasma-membrane adhesion molecules developmental process cell-cell adhesion involved in gastrulation embryonic morphogenesis gastrulation anatomical structure morphogenesis negative regulation of heterotypic cell-cell adhesion negative regulation of cell-cell adhesion chemotaxis negative chemotaxis taxis response to chemical response to external stimulus locomotion protein-containing complex remodeling protein-lipid complex organization very-low-density lipoprotein particle remodeling protein-lipid complex remodeling negative regulation of very-low-density lipoprotein particle remodeling plasma lipoprotein particle organization negative regulation of cellular component organization protein-containing complex organization plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels regulation of very-low-density lipoprotein particle remodeling triglyceride-rich lipoprotein particle remodeling peptidyl-methionine modification macromolecule modification peptidyl-amino acid modification protein metabolic process protein modification process system process regulation of intestinal absorption digestive system process regulation of system process lipid digestion regulation of digestive system process intestinal lipid absorption digestion intestinal absorption regulation of intestinal lipid absorption intestinal cholesterol absorption regulation of intestinal cholesterol absorption protein oxidation cholesterol import cell population proliferation endothelial cell proliferation epithelial cell proliferation lipoprotein biosynthetic process lipoprotein metabolic process organonitrogen compound biosynthetic process cellular component biogenesis cellular component assembly high-density lipoprotein particle assembly protein-containing complex assembly plasma lipoprotein particle assembly protein-lipid complex assembly lipid biosynthetic process glycerophospholipid biosynthetic process phospholipid biosynthetic process glycerolipid biosynthetic process organophosphate biosynthetic process phosphatidylcholine biosynthetic process glucocorticoid metabolic process organic cyclic compound metabolic process steroid metabolic process phospholipid transport organophosphate ester transport phospholipid efflux cellular response to stimulus regulation of signaling small GTPase-mediated signal transduction signaling regulation of small GTPase mediated signal transduction regulation of signal transduction regulation of Cdc42 protein signal transduction regulation of Rho protein signal transduction intracellular signal transduction Rho protein signal transduction Cdc42 protein signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus intracellular signaling cassette regulation of cell communication signal transduction integrin-mediated signaling pathway cell surface receptor signaling pathway regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response negative regulation of response to stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of intracellular signal transduction positive regulation of Rho protein signal transduction positive regulation of small GTPase mediated signal transduction positive regulation of signaling regulation of cholesterol metabolic process organic hydroxy compound metabolic process sterol metabolic process regulation of lipid metabolic process cholesterol metabolic process alcohol metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process regulation of steroid metabolic process secondary alcohol metabolic process positive regulation of cholesterol metabolic process positive regulation of steroid metabolic process positive regulation of small molecule metabolic process sterol homeostasis cholesterol homeostasis steroid biosynthetic process secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process alcohol biosynthetic process regulation of cell adhesion molecule production negative regulation of cell adhesion molecule production cell adhesion molecule production high-density lipoprotein particle clearance plasma lipoprotein particle clearance adrenal gland development endocrine system development gland development animal organ development system development high-density lipoprotein particle remodeling lipid storage maintenance of location response to organic substance response to cytokine regulation of response to cytokine stimulus negative regulation of response to cytokine stimulus regulation of protein modification process regulation of protein phosphorylation regulation of phosphate metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of phosphorylation regulation of phosphorus metabolic process G protein-coupled receptor signaling pathway regulation of phospholipid transport positive regulation of phospholipid efflux regulation of phospholipid efflux positive regulation of phospholipid transport negative regulation of signaling negative regulation of cell communication cytokine-mediated signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus cellular response to organic substance regulation of tumor necrosis factor-mediated signaling pathway regulation of cytokine-mediated signaling pathway negative regulation of tumor necrosis factor-mediated signaling pathway negative regulation of signal transduction cellular response to chemical stimulus negative regulation of cytokine-mediated signaling pathway response to tumor necrosis factor positive regulation of organelle organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of actin filament bundle assembly positive regulation of actin filament bundle assembly actin filament bundle organization positive regulation of stress fiber assembly actin filament-based process stress fiber assembly regulation of actin filament organization actin cytoskeleton organization actomyosin structure organization positive regulation of cellular component biogenesis positive regulation of cytoskeleton organization actin filament organization regulation of cellular component biogenesis positive regulation of supramolecular fiber organization regulation of organelle organization regulation of stress fiber assembly organelle organization contractile actin filament bundle assembly regulation of actomyosin structure organization actin filament bundle assembly regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization positive regulation of hydrolase activity regulation of hydrolase activity	protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space cellular anatomical entity lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle protein-containing complex extracellular region plasma lipoprotein particle high-density lipoprotein particle extracellular space cellular anatomical entity lipoprotein particle protein-lipid complex extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle organelle vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol intracellular vesicle intracellular membrane-bounded organelle intracellular organelle cytoplasmic vesicle endocytic vesicle membrane-enclosed lumen endomembrane system intracellular organelle lumen endoplasmic reticulum lumen organelle lumen endoplasmic reticulum spherical high-density lipoprotein particle plasma membrane membrane early endosome endosome blood microparticle vesicle lumen cytoplasmic vesicle lumen secretory granule lumen secretory granule secretory vesicle endocytic vesicle lumen very-low-density lipoprotein particle triglyceride-rich plasma lipoprotein particle
C [auth B], D [auth C]	GTPase KRas	binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding GDP binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity protein-containing complex binding pyrophosphatase activity GTPase activity G protein activity ribonucleoside triphosphate phosphatase activity molecular function regulator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding protein binding	cellular response to stimulus positive regulation of cell communication small GTPase-mediated signal transduction regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette cellular response to stimulus positive regulation of cell communication small GTPase-mediated signal transduction regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of small GTPase mediated signal transduction positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling Rac protein signal transduction biological regulation positive regulation of intracellular signal transduction regulation of Rac protein signal transduction positive regulation of Rac protein signal transduction regulation of response to stimulus regulation of cell communication cellular process positive regulation of small GTPase mediated signal transduction positive regulation of signaling multicellular organismal process cellular developmental process astrocyte differentiation forebrain development cell development glial cell development multicellular organism development neurogenesis astrocyte development gliogenesis cell differentiation anatomical structure development system development developmental process head development forebrain astrocyte development animal organ development brain development nervous system development central nervous system development glial cell differentiation forebrain astrocyte differentiation multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells epithelium development tube development respiratory tube development lung epithelium development type I pneumocyte differentiation tissue development epithelial cell differentiation lung epithelial cell differentiation lung cell differentiation lung development respiratory system development trans-synaptic signaling synaptic transmission, GABAergic modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling regulation of synaptic transmission, GABAergic cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of biosynthetic process organic substance biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular biosynthetic process branching morphogenesis of an epithelial tube tube morphogenesis lung morphogenesis animal organ morphogenesis epithelial tube morphogenesis morphogenesis of an epithelium tissue morphogenesis anatomical structure morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium regulation of developmental process negative regulation of biological process regulation of cell differentiation regulation of epithelial cell differentiation negative regulation of cellular process regulation of multicellular organismal process negative regulation of cell differentiation regulation of multicellular organismal development negative regulation of epithelial cell differentiation negative regulation of developmental process cellular component organization organelle organization actin cytoskeleton organization actin filament-based process cellular component organization or biogenesis cytoskeleton organization skeletal muscle cell differentiation skeletal muscle tissue development muscle structure development skeletal muscle organ development muscle tissue development muscle organ development response to light stimulus system process learning learning or memory nervous system process visual learning visual behavior cognition associative learning behavior response to radiation response to abiotic stimulus neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death regulation of neuron apoptotic process MAPK cascade Ras protein signal transduction regulation of neuronal synaptic plasticity regulation of synaptic plasticity regulation of long-term neuronal synaptic plasticity regulation of biological quality positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein modification process regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process organonitrogen compound metabolic process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of phosphorylation striated muscle cell differentiation muscle cell differentiation positive regulation of nervous system development positive regulation of cell population proliferation regulation of neurogenesis regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of cell development regulation of nervous system development positive regulation of developmental process regulation of glial cell proliferation positive regulation of cell differentiation positive regulation of neurogenesis cell population proliferation positive regulation of cell development regulation of cell population proliferation positive regulation of multicellular organismal process glial cell proliferation	anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle anchoring junction cell junction cellular anatomical entity focal adhesion cell-substrate junction membrane intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane Golgi membrane Golgi apparatus bounding membrane of organelle mitochondrial membrane mitochondrion organelle outer membrane organelle envelope mitochondrial envelope mitochondrial outer membrane outer membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth D]	IPR000074	Apolipoprotein A/E	Family
C [auth B], D [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C [auth B], D [auth C]	IPR020849	Small GTPase, Ras-type	Family
C [auth B], D [auth C]	IPR001806	Small GTPase	Family
C [auth B], D [auth C]	IPR005225	Small GTP-binding protein domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B [auth D]	Pharos: P02647	familial visceral amyloidosis hypertensive disorder membranous glomerulonephritis coronary artery disease Behcet disease Hypoxia acute lung injury amyloidosis HIV infectious disease peripheral neuropathy cerebrovascular disorder Tangier disease hypoalphalipoproteinemia, primary, 1 inherited lipid metabolism disorder adenocarcinoma familial visceral amyloidosis hypertensive disorder membranous glomerulonephritis coronary artery disease Behcet disease Hypoxia acute lung injury amyloidosis HIV infectious disease peripheral neuropathy cerebrovascular disorder Tangier disease hypoalphalipoproteinemia, primary, 1 inherited lipid metabolism disorder adenocarcinoma granular cell carcinoma hypoalphalipoproteinemia tubular adenocarcinoma malignant mesothelioma atherosclerosis psoriasis type 2 diabetes mellitus abdominal aortic aneurysm drug-induced liver injury lung benign neoplasm familial isolated deficiency of vitamin E gastric neoplasm metabolic disease non-alcoholic fatty liver disease hereditary diffuse gastric adenocarcinoma hypertrophic pyloric stenosis cribriform carcinoma idiopathic membranous glomerulonephritis acquired metabolic disease metabolic syndrome X obesity disorder periodic fever syndrome cribriform carcinoma of breast inborn carbohydrate metabolic disorder lung adenocarcinoma gastric cancer heart disease hepatocellular carcinoma ovarian cancer apolipoprotein A-I deficiency peripheral nervous system disease
C [auth B], D [auth C]	Pharos: P01116	Noonan syndrome juvenile myelomonocytic leukemia cardiofaciocutaneous syndrome acute myeloid leukemia gastric cancer cancer Noonan syndrome 3 cholangiocarcinoma Costello syndrome nasopharyngeal carcinoma subependymal giant cell astrocytoma angiosarcoma urinary bladder cancer astrocytic tumor neuroblastoma Noonan syndrome juvenile myelomonocytic leukemia cardiofaciocutaneous syndrome acute myeloid leukemia gastric cancer cancer Noonan syndrome 3 cholangiocarcinoma Costello syndrome nasopharyngeal carcinoma subependymal giant cell astrocytoma angiosarcoma urinary bladder cancer astrocytic tumor neuroblastoma squamous cell carcinoma adenoma cardiofaciocutaneous syndrome 2 ovarian cancer pilocytic astrocytoma non-small cell lung carcinoma endometriosis exocrine pancreatic carcinoma pancreatic ductal adenocarcinoma uterine cancer myelodysplastic syndrome gastric carcinoma papillary adenoma liver cancer colorectal cancer gemistocytic astrocytoma penile neoplasm granular cell carcinoma plasma cell myeloma breast adenocarcinoma nevus, epidermal hereditary diffuse gastric adenocarcinoma adenocarcinoma carcinoma Splenomegaly cecal neoplasm thyroid gland carcinoma anaplastic astrocytoma childhood cerebral astrocytoma autoimmune lymphoproliferative syndrome lung cancer breast cancer protoplasmic astrocytoma malignant colon neoplasm thyroid adenoma cecum cancer fibrillary astrocytoma juvenile pilocytic astrocytoma Toriello-Lacassie-Droste syndrome gallbladder cancer arteriovenous malformations of the brain autoimmune lymphoproliferative syndrome type 4 lung adenocarcinoma prostate cancer breast carcinoma lymphoma sarcomatoid carcinoma intellectual disability intrahepatic cholangiocarcinoma cardiomyopathy malignant pancreatic neoplasm familial pancreatic carcinoma juvenile idiopathic arthritis tubular adenocarcinoma follicular thyroid adenoma anemia microcystic adenoma atypical teratoid rhabdoid tumor congenital anemia uterine disease B-cell chronic lymphocytic leukemia liver neoplasm craniosynostosis benign neoplasm of pancreas lung benign neoplasm hepatocellular carcinoma lung disease digestive system disease breast disease Lynch syndrome encephalocraniocutaneous lipomatosis hydrops fetalis epidermal nevus syndrome oral cavity neoplasm cardiofaciocutaneous syndrome 1 osteosarcoma ovarian disease cerebral astrocytoma medullary thyroid gland carcinoma pancreatic intraductal papillary-mucinous carcinoma pancreatic neoplasm linear nevus sebaceus syndrome colonic neoplasm colorectal carcinoma myopathy gastric neoplasm Parkinson disease glioblastoma benign colon neoplasm Pick disease cribriform carcinoma hematologic disease bile duct cancer dermatomyositis rheumatoid arthritis inflammatory linear verrucous epidermal nevus juvenile dermatomyositis thyroid gland follicular carcinoma ovarian neoplasm cervical carcinoma ulcerative colitis medulloblastoma pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma urinary bladder neoplasm astrocytoma (excluding glioblastoma) pancreatitis colorectal adenocarcinoma uterine cervix carcinoma in situ gastrointestinal stromal tumor penile cancer verrucous nevus benign neoplasm cribriform carcinoma of breast bladder transitional cell carcinoma lung carcinoma diffuse astrocytoma psoriasis malignant ependymoma Emery-Dreifuss muscular dystrophy oligodendroglioma squamous cell lung carcinoma osteogenesis imperfecta thyroid cancer amyotrophic lateral sclerosis ovarian carcinoma thyroid gland papillary carcinoma Charcot-Marie-Tooth disease undifferentiated carcinoma gallbladder neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia chronic myelomonocytic leukemia

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.