6VTM

Human Cathepsin-G Inhibited by S. aureus EapH1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6vtma_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Cathepsin G	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d6vtmd_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Cathepsin G	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d6vtmc_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Cathepsin G	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d6vtmg_	All beta proteins	Trypsin-like serine proteases	Trypsin-like serine proteases	Eukaryotic proteases	Cathepsin G	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Trypsin-like serine proteases	8032449	3000114	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Trypsin-like serine proteases	8032449	3000114	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Trypsin-like serine proteases	8032449	3000114	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Trypsin-like serine proteases	8032449	3000114	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Superantigen toxins C-terminal domain-like	8051837	3000376	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Superantigen toxins C-terminal domain-like	8051837	3000376	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Superantigen toxins C-terminal domain-like	8051837	3000376	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Superantigen toxins C-terminal domain-like	8051837	3000376	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00089	e6vtmA1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
D	PF00089	e6vtmD1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
C	PF00089	e6vtmC1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
G	PF00089	e6vtmG1	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: FMN-binding split barrel 2	F: PF00089	ECOD (1.6)
E	PF03642	e6vtmE1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF03642	ECOD (1.6)
B	PF03642	e6vtmB1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF03642	ECOD (1.6)
F	PF03642	e6vtmF1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF03642	ECOD (1.6)
H	PF03642	e6vtmH1	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: PF03642	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (utative)
D	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (utative)
C	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (utative)
G	2.40.10.10	Mainly Beta	Beta Barrel	Thrombin, subunit H	Trypsin-like serine proteases	CATH (utative)
E	3.10.20.120	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (utative)
B	3.10.20.120	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (utative)
F	3.10.20.120	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (utative)
H	3.10.20.120	Alpha Beta	Roll	Ubiquitin-like (UB roll)		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, D, G	PF00089	Trypsin (Trypsin)	Trypsin	-	Domain
B, E, F, H	PF03642	MAP domain (MAP)	MAP domain	This presumed 110 amino acid residue domain is found in multiple copies in MAP (MHC class II analogue protein) Swiss:Q9Z4J2 [1]. The protein has been found in a wide range of extracellular matrix proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, D, G	Cathepsin G	peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity serine hydrolase activity serine-type peptidase activity peptidase activity catalytic activity, acting on a protein hydrolase activity catalytic activity protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity serine hydrolase activity serine-type peptidase activity serine-type endopeptidase activity endopeptidase activity enzyme binding protease binding caspase binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process regulation of systemic arterial blood pressure by renin-angiotensin regulation of systemic arterial blood pressure by hormone multicellular organismal process peptide hormone processing regulation of systemic arterial blood pressure mediated by a chemical signal system process cellular biosynthetic process signaling receptor ligand precursor processing protein maturation organic substance metabolic process circulatory system process proteolysis organic substance biosynthetic process amide metabolic process protein metabolic process regulation of biological quality blood circulation organonitrogen compound metabolic process regulation of blood pressure regulation of hormone levels cellular metabolic process biological regulation regulation of systemic arterial blood pressure by circulatory renin-angiotensin primary metabolic process gene expression macromolecule biosynthetic process hormone metabolic process regulation of systemic arterial blood pressure endocrine process biosynthetic process regulation of angiotensin levels in blood protein processing metabolic process cellular process macromolecule metabolic process angiotensin maturation regulation of biological process response to stimulus immune response positive regulation of biological process positive regulation of response to stimulus positive regulation of immune response regulation of response to stimulus immune system process regulation of immune response regulation of immune system process positive regulation of immune system process cellular response to stimulus response to organic substance regulation of cellular process cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication cellular response to chemical stimulus response to chemical cellular response to cytokine stimulus cellular response to organic substance signal transduction neutrophil-mediated killing of symbiont cell biological process involved in interspecies interaction between organisms disruption of cell in another organism response to biotic stimulus myeloid leukocyte mediated immunity biological process involved in symbiotic interaction defense response to bacterium neutrophil mediated immunity response to stress response to bacterium leukocyte mediated immunity response to external biotic stimulus biological process involved in interaction with symbiont killing of cells of another organism neutrophil-mediated killing of bacterium neutrophil-mediated killing of gram-positive bacterium neutrophil mediated cytotoxicity response to other organism defense response defense response to Gram-positive bacterium response to external stimulus defense response to symbiont leukocyte mediated cytotoxicity immune effector process killing by host of symbiont cells defense response to other organism disruption of anatomical structure in another organism cell killing neutrophil activation cell activation myeloid leukocyte activation granulocyte activation leukocyte activation humoral immune response antibacterial humoral response antimicrobial humoral response response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to lipid response to molecule of bacterial origin cellular component organization cellular component disassembly extracellular matrix disassembly extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization regulation of body fluid levels homotypic cell-cell adhesion regulation of cell activation positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion coagulation regulation of cell-cell adhesion regulation of multicellular organismal process response to wounding positive regulation of cellular process wound healing regulation of homotypic cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion hemostasis platelet aggregation blood coagulation regulation of platelet activation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation platelet activation cell chemotaxis chemotaxis monocyte chemotaxis leukocyte migration taxis mononuclear cell migration myeloid leukocyte migration cell migration cell motility leukocyte chemotaxis locomotion protein phosphorylation phosphorylation macromolecule modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process defense response to fungus response to fungus defense response to Gram-negative bacterium regulation of leukocyte activation negative regulation of biological process lymphocyte activation negative regulation of lymphocyte activation leukocyte cell-cell adhesion negative regulation of cell adhesion T cell activation negative regulation of cellular process regulation of T cell activation negative regulation of cell activation negative regulation of T cell activation negative regulation of immune system process negative regulation of leukocyte cell-cell adhesion negative regulation of cell-cell adhesion regulation of leukocyte cell-cell adhesion negative regulation of multicellular organismal process negative regulation of leukocyte activation regulation of lymphocyte activation purinergic nucleotide receptor signaling pathway biofilm matrix organization biofilm matrix disassembly	intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule membrane extracellular exosome membrane-bounded organelle intracellular anatomical structure cytoplasmic ribonucleoprotein granule cellular anatomical entity ribonucleoprotein granule intracellular organelle organelle intracellular non-membrane-bounded organelle cytoplasm supramolecular complex non-membrane-bounded organelle cytoplasmic stress granule membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix cytosol plasma membrane intracellular membrane-bounded organelle intracellular vesicle endomembrane system cytoplasmic vesicle secretory granule secretory vesicle lytic vacuole membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen intracellular organelle lumen lysosome vesicle lumen azurophil granule vacuole secretory granule lumen azurophil granule lumen organelle lumen primary lysosome nucleus
B, E, F, H	MAP domain-containing protein	-	-	extracellular region cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, D, G	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A, C, D, G	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C, D, G	IPR001314	Peptidase S1A, chymotrypsin family	Family
A, C, D, G	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A, C, D, G	IPR001254	Serine proteases, trypsin domain	Domain
A, C, D, G	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B, E, F, H	IPR005298	MAP domain	Domain
B, E, F, H	IPR016091	Superantigen toxin, C-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C, D, G	Pharos: P08311	atopic eczema invasive ductal breast carcinoma mantle cell lymphoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma vitiligo breast cancer lung adenocarcinoma multiple sclerosis pancreatic intraductal papillary-mucinous neoplasm sarcoidosis cutaneous lupus erythematosus lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia atopic eczema invasive ductal breast carcinoma mantle cell lymphoma pancreatic intraductal papillary-mucinous carcinoma plasma cell myeloma vitiligo breast cancer lung adenocarcinoma multiple sclerosis pancreatic intraductal papillary-mucinous neoplasm sarcoidosis cutaneous lupus erythematosus lymphoplasmacytic lymphoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Systemic AL amyloidosis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.