6VTJ

Structure of a thiolation-reductase di-domain from an archaeal non-ribosomal peptide synthetase

External Resource: Annotation


Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF07993Male sterility protein (NAD_binding_4)Male sterility protein- Family
PF00550Phosphopantetheine attachment site (PP-binding)Phosphopantetheine attachment siteA 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes memb ...A 4'-phosphopantetheine prosthetic group is attached through a serine. This prosthetic group acts as a a 'swinging arm' for the attachment of activated fatty acid and amino-acid groups. This domain forms a four helix bundle. This family includes members not included in Prosite. The inclusion of these members is supported by sequence analysis and functional evidence. The related domain of Swiss:P19828 has the attachment serine replaced by an alanine.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Non-ribosomal peptide synthetase -

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR009081Phosphopantetheine binding ACP domainDomain
IPR013120Fatty acyl-coenzyme A reductase, NAD-binding domainDomain
IPR010071Amino acid adenylation domainDomain
IPR020845AMP-binding, conserved siteConserved Site
IPR023213Chloramphenicol acetyltransferase-like domain superfamilyHomologous Superfamily
IPR045851AMP-binding enzyme, C-terminal domain superfamilyHomologous Superfamily
IPR042099ANL, N-terminal domainHomologous Superfamily
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
IPR001242Condensation domainDomain
IPR036736ACP-like superfamilyHomologous Superfamily
IPR025110AMP-binding enzyme, C-terminal domainDomain
IPR000873AMP-dependent synthetase/ligase domainDomain
IPR010080Thioester reductase-like domainDomain