6VK7

Crystal Structure of reduced Methylosinus trichosporium OB3b Soluble Methane Monooxygenase Hydroxylase

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6vk7a_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Methylosinus trichosporium OB3b ) [TaxId: 595536 ],	SCOPe (2.08)
B	d6vk7b_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Methylosinus trichosporium OB3b ) [TaxId: 595536 ],	SCOPe (2.08)
C	d6vk7c_	All alpha proteins	Open three-helical up-and-down bundle	Methane monooxygenase hydrolase, gamma subunit	Methane monooxygenase hydrolase, gamma subunit	automated matches	(Methylosinus trichosporium OB3b ) [TaxId: 595536 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ferritin-like	8037031	3001658	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ferritin-like	8096408	3001658	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Methane monooxygenase hydrolase gamma subunit	8096406	3001468	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF02332	e6vk7A1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PF02332	ECOD (1.6)
B	PF02332	e6vk7B1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PF02332	ECOD (1.6)
C	PF02964	e6vk7C1	A: alpha arrays	X: Methane monooxygenase hydrolase gamma subunit-like	H: Methane monooxygenase hydrolase gamma subunit (From Topology)	T: Methane monooxygenase hydrolase gamma subunit	F: PF02964	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
B	PF02332	Methane/Phenol/Alkene Hydroxylase (Phenol_Hydrox)	Methane/Phenol/Alkene Hydroxylase	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and larg ...	This protein family includes several components of multicomponent enzyme systems predominantly found in Proteobacteria and Actinobacteria, including subunits alpha and beta of a methane monooxygenase and an alkene monooxygenase system, small and large subunits of propane 2-monooxygenase system and P1 protein of phenol hydroxylase [1-4].	Domain
C	PF02964	Methane monooxygenase, hydrolase gamma chain (MeMO_Hyd_G)	Methane monooxygenase, hydrolase gamma chain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Methane monooxygenase component A alpha chain	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen methane monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity methane monooxygenase NADH activity methane monooxygenase NADPH activity cation binding ion binding binding metal ion binding small molecule binding	cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process	-
B	Methane monooxygenase	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity	-	-
C	Methane monooxygenase	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen methane monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen catalytic activity	organic substance metabolic process cellular metabolic process cellular alkane metabolic process methane metabolic process metabolic process cellular process hydrocarbon metabolic process	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
A	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
B	IPR009078	Ferritin-like superfamily	Homologous Superfamily
B	IPR003430	Propane/methane/phenol/toluene hydroxylase	Family
B	IPR012078	Methane/phenol monooxygenase, hydroxylase component	Family
B	IPR012348	Ribonucleotide reductase-like	Homologous Superfamily
C	IPR015952	Methane monooxygenase, gamma chain, domain 1	Homologous Superfamily
C	IPR015953	Methane monooxygenase, gamma chain, domain 2	Homologous Superfamily
C	IPR036123	Methane monooxygenase, gamma chain superfamily	Homologous Superfamily
C	IPR004222	Methane monooxygenase, gamma chain	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.