Annotations: 6VK0

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth C]	PF04511	e6vk0C1	A: alpha bundles	X: Rhomboid-like (From Topology)	H: Rhomboid-like (From Topology)	T: Rhomboid-like	F: PF04511	ECOD (1.6)
C [auth A]	PF08238	e6vk0A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: PF08238	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth C]	PF04511	Der1-like family (DER1)	Der1-like family	-	Family
C [auth A]	PF08238	Sel1 repeat (Sel1)	Sel1 repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth D]	U1 SNP1-associating protein 1	molecular adaptor activity identical protein binding protein binding binding	regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process protein ubiquitination positive regulation of macromolecule metabolic process protein metabolic process regulation of protein modification by small protein conjugation or removal regulation of protein modification process positive regulation of protein metabolic process positive regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination positive regulation of post-translational protein modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process organic substance metabolic process protein ubiquitination positive regulation of macromolecule metabolic process protein metabolic process regulation of protein modification by small protein conjugation or removal protein modification process positive regulation of protein modification by small protein conjugation or removal regulation of biological process positive regulation of protein ubiquitination organonitrogen compound metabolic process regulation of post-translational protein modification regulation of protein metabolic process protein autoubiquitination biological regulation primary metabolic process regulation of macromolecule metabolic process macromolecule modification metabolic process positive regulation of protein autoubiquitination macromolecule metabolic process post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal RNA splicing cellular biosynthetic process cellular metabolic process RNA metabolic process gene expression mRNA processing mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process organic cyclic compound metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome organic substance biosynthetic process cellular process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile RNA processing	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-L complex
B [auth C]	Degradation in the endoplasmic reticulum protein 1	ubiquitin-specific protease binding protein binding binding enzyme binding protease binding misfolded protein binding	protein localization cellular localization establishment of protein localization nitrogen compound transport transport misfolded protein transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization protein localization cellular localization establishment of protein localization nitrogen compound transport transport misfolded protein transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization cellular process intracellular protein transport organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process protein quality control for misfolded or incompletely synthesized proteins organic substance catabolic process cellular response to stimulus protein exit from endoplasmic reticulum response to organic substance response to stimulus ERAD pathway cellular response to stress response to stress response to endoplasmic reticulum stress endoplasmic reticulum to cytosol transport response to organonitrogen compound response to nitrogen compound proteasomal protein catabolic process response to chemical retrograde protein transport, ER to cytosol regulation of biological process regulation of cellular process cellular response to topologically incorrect protein signaling biological regulation endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein cell communication cellular response to chemical stimulus response to topologically incorrect protein signal transduction cellular response to organic substance	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-L complex
C [auth A]	ERAD-associated E3 ubiquitin-protein ligase component HRD3	-	cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis cellular response to stimulus response to organic substance catabolic process response to stimulus proteolysis involved in protein catabolic process carbohydrate derivative metabolic process ubiquitin-dependent glycoprotein ERAD pathway macromolecule catabolic process response to glycoprotein ERAD pathway organic substance metabolic process cellular response to stress response to stress proteolysis protein metabolic process response to endoplasmic reticulum stress organonitrogen compound catabolic process carbohydrate derivative catabolic process glycoprotein catabolic process organonitrogen compound metabolic process response to organonitrogen compound response to oxygen-containing compound primary metabolic process response to nitrogen compound proteasomal protein catabolic process protein catabolic process glycoprotein metabolic process response to chemical metabolic process cellular process macromolecule metabolic process organic substance catabolic process detection of stimulus detection of unfolded protein response to topologically incorrect protein detection of chemical stimulus response to unfolded protein protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport localization establishment of localization in cell cellular macromolecule localization endoplasmic reticulum to cytosol transport organic substance transport intracellular transport establishment of localization protein transport retrograde protein transport, ER to cytosol macromolecule localization intracellular protein transport negative regulation of post-translational protein modification regulation of protein modification process negative regulation of biological process regulation of protein autoubiquitination regulation of protein ubiquitination regulation of primary metabolic process protein ubiquitination negative regulation of protein modification process regulation of protein modification by small protein conjugation or removal protein modification process negative regulation of protein ubiquitination negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of biological process negative regulation of protein autoubiquitination negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification regulation of protein metabolic process protein autoubiquitination negative regulation of metabolic process biological regulation regulation of macromolecule metabolic process macromolecule modification post-translational protein modification regulation of metabolic process protein modification by small protein conjugation protein modification by small protein conjugation or removal	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-M complex membrane-enclosed lumen intracellular organelle lumen endoplasmic reticulum lumen organelle lumen luminal surveillance complex Hrd1p ubiquitin ligase ERAD-L complex
D [auth B]	ERAD-associated E3 ubiquitin-protein ligase HRD1	aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity cation binding ion binding binding metal ion binding small molecule binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity transferase activity catalytic activity ubiquitin-protein transferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity cation binding ion binding binding metal ion binding small molecule binding identical protein binding protein binding	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process cellular response to stimulus response to organic substance response to stimulus ERAD pathway cellular response to stress response to stress response to endoplasmic reticulum stress response to organonitrogen compound response to nitrogen compound proteasomal protein catabolic process response to chemical cellular process protein polyubiquitination protein ubiquitination macromolecule modification post-translational protein modification protein modification process protein K48-linked ubiquitination protein modification by small protein conjugation protein modification by small protein conjugation or removal fungal-type cell wall organization cellular component organization fungal-type cell wall organization or biogenesis cell wall organization or biogenesis cell wall organization cellular component organization or biogenesis external encapsulating structure organization protein autoubiquitination protein localization protein exit from endoplasmic reticulum cellular localization establishment of protein localization nitrogen compound transport transport localization establishment of localization in cell cellular macromolecule localization endoplasmic reticulum to cytosol transport organic substance transport intracellular transport establishment of localization protein transport retrograde protein transport, ER to cytosol macromolecule localization intracellular protein transport regulation of biological process regulation of cellular process cellular response to topologically incorrect protein signaling biological regulation endoplasmic reticulum unfolded protein response cellular response to unfolded protein response to unfolded protein cell communication cellular response to chemical stimulus response to topologically incorrect protein signal transduction cellular response to organic substance	membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane membrane-bounded organelle protein-containing complex cytoplasmic ubiquitin ligase complex intracellular anatomical structure ubiquitin ligase complex membrane protein complex transferase complex endomembrane system ER ubiquitin ligase complex endoplasmic reticulum subcompartment intracellular organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum protein-containing complex endoplasmic reticulum membrane catalytic complex organelle subcompartment membrane cellular anatomical entity intracellular membrane-bounded organelle organelle endoplasmic reticulum cytoplasm Hrd1p ubiquitin ligase complex organelle membrane intracellular protein-containing complex Hrd1p ubiquitin ligase ERAD-M complex Hrd1p ubiquitin ligase ERAD-L complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth D]	IPR029071	Ubiquitin-like domain superfamily	Homologous Superfamily
A [auth D]	IPR000626	Ubiquitin-like domain	Domain
B [auth C]	IPR007599	Derlin	Family
C [auth A]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
C [auth A]	IPR006597	Sel1-like repeat	Repeat
D [auth B]	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
D [auth B]	IPR001841	Zinc finger, RING-type	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth D], B [auth C], C [auth A], D [auth B]	OPM	Transmembrane	Alpha-helical polytopic	AAA-ATPase superfamily, transmembrane	ER retrotranslocon family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth D], B [auth C], C [auth A], D [auth B]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth D], B [auth C], C [auth A], D [auth B]	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A [auth D], B [auth C], C [auth A], D [auth B]	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sec, Translocase, and Insertase Proteins	ER-associated protein degradation (ERAD) protein Hrd1 ubiquitin ligase complex

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.