Annotations: 6VFU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	PF00028	e6vfuC2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
A [auth C]	PF08266	e6vfuC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08266	ECOD (1.6)
B [auth A]	PF00028	e6vfuA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
B [auth A]	PF08266	e6vfuA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08266	ECOD (1.6)
C [auth B]	PF00028	e6vfuB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF00028	ECOD (1.6)
C [auth B]	PF08266	e6vfuB2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF08266	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)
B [auth A]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)
C [auth B]	2.60.40.60	Mainly Beta	Sandwich	Immunoglobulin-like	Cadherins	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C], B [auth A], C [auth B]	PF08266	Cadherin-like (Cadherin_2)	Cadherin-like	This cadherin domain is usually the most N-terminal copy of the domain.	Domain
A [auth C], B [auth A], C [auth B]	PF00028	Cadherin domain (Cadherin)	Cadherin domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C], B [auth A], C [auth B]	Protocadherin-19	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding	cell adhesion cell-cell adhesion cellular process cell-cell adhesion via plasma-membrane adhesion molecules homophilic cell adhesion via plasma membrane adhesion molecules	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C], B [auth A], C [auth B]	IPR015919	Cadherin-like superfamily	Homologous Superfamily
A [auth C], B [auth A], C [auth B]	IPR020894	Cadherin conserved site	Conserved Site
A [auth C], B [auth A], C [auth B]	IPR013164	Cadherin, N-terminal	Domain
A [auth C], B [auth A], C [auth B]	IPR002126	Cadherin-like	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C], B [auth A], C [auth B]	Pharos: Q8TAB3	developmental and epileptic encephalopathy, 9 epilepsy Dravet syndrome intellectual disability ovarian cancer astrocytic tumor autism, susceptibility to, X-linked 2 glioblastoma large cell medulloblastoma Mental Retardation, X-Linked atypical teratoid rhabdoid tumor malignant ependymoma non-small cell lung carcinoma developmental and epileptic encephalopathy, 6 ductal breast carcinoma in situ developmental and epileptic encephalopathy, 9 epilepsy Dravet syndrome intellectual disability ovarian cancer astrocytic tumor autism, susceptibility to, X-linked 2 glioblastoma large cell medulloblastoma Mental Retardation, X-Linked atypical teratoid rhabdoid tumor malignant ependymoma non-small cell lung carcinoma developmental and epileptic encephalopathy, 6 ductal breast carcinoma in situ invasive ductal breast carcinoma medulloblastoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.