Annotations: 6VCX

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6vcxa1	Alpha and beta proteins (a+b)	S-adenosylmethionine synthetase	S-adenosylmethionine synthetase	automated matches	automated matches	Mouse-ear cress (Arabidopsis thaliana ) [TaxId: 3702 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00438	e6vcxA3	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: S-adenosylmethionine synthetase (From Topology)	T: S-adenosylmethionine synthetase	F: PF00438	ECOD (1.6)
A	PF02772	e6vcxA2	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: S-adenosylmethionine synthetase (From Topology)	T: S-adenosylmethionine synthetase	F: PF02772	ECOD (1.6)
A	PF02773	e6vcxA1	A: a+b two layers	X: Alpha-lytic protease prodomain-like	H: S-adenosylmethionine synthetase (From Topology)	T: S-adenosylmethionine synthetase	F: PF02773	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00438	S-adenosylmethionine synthetase, N-terminal domain (S-AdoMet_synt_N)	S-adenosylmethionine synthetase, N-terminal domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	Domain
A	PF02773	S-adenosylmethionine synthetase, C-terminal domain (S-AdoMet_synt_C)	S-adenosylmethionine synthetase, C-terminal domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	Domain
A	PF02772	S-adenosylmethionine synthetase, central domain (S-AdoMet_synt_M)	S-adenosylmethionine synthetase, central domain	The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	S-adenosylmethionine synthase 1	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding methionine adenosyltransferase activity transferase activity transferase activity, transferring alkyl or aryl (other than methyl) groups catalytic activity cation binding metal ion binding	cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process cellular biosynthetic process sulfur compound biosynthetic process organic substance metabolic process biosynthetic process S-adenosylmethionine biosynthetic process S-adenosylmethionine metabolic process organic substance biosynthetic process sulfur compound metabolic process olefinic compound biosynthetic process cellular metabolic process small molecule metabolic process metabolic process cellular process one-carbon metabolic process cellular biosynthetic process sulfur compound biosynthetic process organic substance metabolic process biosynthetic process S-adenosylmethionine biosynthetic process S-adenosylmethionine metabolic process organic substance biosynthetic process sulfur compound metabolic process olefinic compound biosynthetic process ethylene metabolic process hydrocarbon metabolic process olefin biosynthetic process cellular alkene metabolic process alkene biosynthetic process ethylene biosynthetic process olefinic compound metabolic process olefin metabolic process hydrocarbon biosynthetic process	extracellular region cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery external encapsulating structure plant-type cell wall cell wall

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR022636	S-adenosylmethionine synthetase superfamily	Homologous Superfamily
A	IPR022629	S-adenosylmethionine synthetase, central domain	Domain
A	IPR022628	S-adenosylmethionine synthetase, N-terminal	Domain
A	IPR022631	S-adenosylmethionine synthetase, conserved site	Conserved Site
A	IPR022630	S-adenosylmethionine synthetase, C-terminal	Domain
A	IPR002133	S-adenosylmethionine synthetase	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.