Annotations: 6V6H

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	HAL/PAL-like	8099481	4001447	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	L-aspartase-like	8099482	3001572	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	L-aspartase-like	8099482	3001572	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	L-aspartase-like	8099482	3001572	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	L-aspartase-like	8099482	3001572	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PF00221	e6v6hA2	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: PF00221	ECOD (1.6)
A	PF00221	e6v6hA1	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: PF00221	ECOD (1.6)
B	PF00221	e6v6hB1	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: PF00221	ECOD (1.6)
B	PF00221	e6v6hB2	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: PF00221	ECOD (1.6)
C	PF00221	e6v6hC2	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: PF00221	ECOD (1.6)
C	PF00221	e6v6hC1	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: PF00221	ECOD (1.6)
D	PF00221	e6v6hD2	A: alpha arrays	X: L-aspartase N-terminal domain-like (From Topology)	H: L-aspartase N-terminal domain-like (From Topology)	T: L-aspartase N-terminal domain-like	F: PF00221	ECOD (1.6)
D	PF00221	e6v6hD1	A: alpha arrays	X: L-aspartase middle domain-like	H: L-aspartase middle domain-like (From Topology)	T: L-aspartase middle domain-like	F: PF00221	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00221	Aromatic amino acid lyase (Lyase_aromatic)	Aromatic amino acid lyase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Histidine ammonia-lyase	histidine ammonia-lyase activity lyase activity ammonia-lyase activity catalytic activity carbon-nitrogen lyase activity	catabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process histidine catabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process organic substance metabolic process carboxylic acid catabolic process glutamate metabolic process amide catabolic process small molecule metabolic process catabolic process oxoacid metabolic process amino acid metabolic process organic acid metabolic process histidine catabolic process organic acid catabolic process alpha-amino acid metabolic process glutamine family amino acid metabolic process cellular catabolic process organic substance metabolic process carboxylic acid catabolic process glutamate metabolic process amide catabolic process small molecule metabolic process amide metabolic process histidine metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process cellular metabolic process dicarboxylic acid metabolic process carboxylic acid metabolic process histidine catabolic process to glutamate and formamide primary metabolic process L-amino acid metabolic process proteinogenic amino acid metabolic process metabolic process cellular process small molecule catabolic process formamide metabolic process organic substance catabolic process histidine catabolic process to glutamate and formate monocarboxylic acid metabolic process formate metabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR024083	Fumarase/histidase, N-terminal	Homologous Superfamily
A, B, C, D	IPR001106	Aromatic amino acid lyase	Family
A, B, C, D	IPR022313	Phenylalanine/histidine ammonia-lyases, active site	Active Site
A, B, C, D	IPR008948	L-Aspartase-like	Homologous Superfamily
A, B, C, D	IPR005921	Histidine ammonia-lyase	Family

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, C, D	CSS	Parent Component: CYS RESID: AA0269 PSI-MOD : L-cysteine persulfide MOD:00274
A, B, C, D	MDO	Parent Component: ALA, SER, GLY RESID: AA0269

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.