Annotations: 6V6D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	F_UNCLASSIFIED	e6v6dA1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
B	F_UNCLASSIFIED	e6v6dB1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
C	F_UNCLASSIFIED	e6v6dC1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e6v6dD1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
E	F_UNCLASSIFIED	e6v6dE1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
F	F_UNCLASSIFIED	e6v6dF1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)
G	F_UNCLASSIFIED	e6v6dG1	A: alpha bundles	X: Connexin 26 (From Topology)	H: Connexin 26 (From Topology)	T: Connexin 26	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G	PF00876	Innexin (Innexin)	Innexin	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G	Pannexin-1	protein binding binding signaling receptor binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding wide pore channel activity passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity enzyme binding protease binding protein binding binding signaling receptor binding cytoskeletal protein binding actin binding protein-containing complex binding actin filament binding wide pore channel activity passive transmembrane transporter activity channel activity transporter activity transmembrane transporter activity enzyme binding protease binding scaffold protein binding narrow pore channel activity leak channel activity transmembrane transporter binding gap junction channel activity structural molecule activity calcium channel activity monoatomic cation transmembrane transporter activity monoatomic ion channel activity monoatomic cation channel activity calcium ion transmembrane transporter activity inorganic molecular entity transmembrane transporter activity inorganic cation transmembrane transporter activity monoatomic ion transmembrane transporter activity metal ion transmembrane transporter activity identical protein binding	developmental process sexual reproduction cellular developmental process reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation cell differentiation anatomical structure development germ cell development developmental process sexual reproduction cellular developmental process reproductive process oogenesis multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism female gamete generation developmental process involved in reproduction gamete generation cell differentiation anatomical structure development germ cell development cellular process multicellular organismal process regulation of cellular process interleukin-1 production cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process organic substance metabolic process positive regulation of interleukin-1 alpha production positive regulation of biosynthetic process regulation of cytokine production organic substance biosynthetic process cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process regulation of interleukin-1 production cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression regulation of interleukin-1 alpha production macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression interleukin-1 alpha production biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process positive regulation of cellular biosynthetic process response to stimulus response to stress response to ischemia signaling cell-cell signaling cell communication localization transport monoatomic ion transport monoatomic cation transport establishment of localization regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production interleukin-1 beta production response to organic substance response to chemical response to organonitrogen compound response to organophosphorus response to oxygen-containing compound response to nitrogen compound response to ATP response to purine-containing compound response to organic cyclic compound regulation of immune effector process regulation of immune system process positive regulation of immune system process regulation of cytokine production involved in immune response immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response immune system process positive regulation of cytokine production involved in immune response macrophage cytokine production calcium ion transport metal ion transport	membrane cellular anatomical entity cell-cell junction anchoring junction gap junction cell junction cell periphery plasma membrane protein-containing complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system membrane cellular anatomical entity cell-cell junction anchoring junction gap junction cell junction cell periphery plasma membrane protein-containing complex membrane-bounded organelle intracellular anatomical structure organelle subcompartment intracellular membrane-bounded organelle endomembrane system endoplasmic reticulum subcompartment intracellular organelle organelle nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum cytoplasm organelle membrane endoplasmic reticulum membrane cell projection bleb plasma membrane bounded cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G	IPR000990	Innexin	Family
A, B, C, D, E A, B, C, D, E, F, G	IPR039099	Pannexin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G	Pharos: Q96RD7	adenoma Hashimoto thyroiditis lung cancer psoriasis cutaneous lupus erythematosus invasive ductal breast carcinoma medulloblastoma ulcerative colitis diabetes mellitus juvenile dermatomyositis ovarian cancer

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A, B, C, D, E A, B, C, D, E, F, G	OPM	Transmembrane	Alpha-helical polytopic	Tetraspan junctional complexes	Pannexin

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A, B, C, D, E A, B, C, D, E, F, G	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.