6V3H

Structure of NPC1-like intracellular cholesterol transporter 1 (NPC1L1) in complex with an ezetimibe analog

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD
Membrane Protein Annotation: mpstruc

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF02460	Patched family (Patched)	Patched family	-	Family
A	PF16414	Niemann-Pick C1 N terminus (NPC1_N)	Niemann-Pick C1 N terminus	This is the N-terminal domain of Niemann-Pick C1 family proteins. This family of proteins mediates transport of cholesterol from the intestinal lumen to enterocytes. This domain contains a cholesterol-binding pocket [1-2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	NPC1-like intracellular cholesterol transporter 1	small GTPase binding protein binding binding enzyme binding GTPase binding sterol binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity small GTPase binding protein binding binding enzyme binding GTPase binding sterol binding organic cyclic compound binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding lipid transporter activity transporter activity heterocyclic compound binding identical protein binding protein homodimerization activity protein dimerization activity cytoskeletal protein binding myosin V binding myosin binding vitamin binding vitamin E binding	response to stimulus response to activity response to muscle activity response to chemical response to xenobiotic stimulus localization transport vitamin transport establishment of localization organic cyclic compound metabolic process vitamin E metabolic process organic substance metabolic process fat-soluble vitamin metabolic process organic hydroxy compound metabolic process response to stimulus response to activity response to muscle activity response to chemical response to xenobiotic stimulus localization transport vitamin transport establishment of localization organic cyclic compound metabolic process vitamin E metabolic process organic substance metabolic process fat-soluble vitamin metabolic process organic hydroxy compound metabolic process metabolic process small molecule metabolic process vitamin metabolic process cellular response to stimulus cellular response to stress cellular response to sterol depletion response to stress cellular process response to sterol depletion macromolecule localization organic substance transport lipid localization cholesterol transport lipid transport sterol transport organic hydroxy compound transport sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis sterol metabolic process steroid metabolic process cholesterol metabolic process lipid biosynthetic process alcohol metabolic process organic substance biosynthetic process steroid biosynthetic process secondary alcohol biosynthetic process small molecule biosynthetic process cholesterol biosynthetic process primary metabolic process secondary alcohol metabolic process biosynthetic process sterol biosynthetic process organic hydroxy compound biosynthetic process organic cyclic compound biosynthetic process alcohol biosynthetic process lipid metabolic process intestinal lipid absorption multicellular organismal process digestion system process intestinal absorption digestive system process intestinal cholesterol absorption lipid digestion organonitrogen compound metabolic process lipoprotein metabolic process protein metabolic process macromolecule metabolic process cholesterol import	cell periphery apical part of cell membrane plasma membrane plasma membrane region cellular anatomical entity apical plasma membrane brush border membrane cluster of actin-based cell projections plasma membrane bounded cell projection brush border cell projection cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR003392	Protein patched/dispatched	Family
A	IPR032190	Niemann-Pick C1, N-terminal	Domain
A	IPR004765	NPC1-like	Family
A	IPR000731	Sterol-sensing domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A	OPM	Transmembrane	Alpha-helical polytopic	Resistance-nodulation-cell division	Patched family

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A	MemProtMD	Annotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

Chains	Resource Link	Group	Subgroup	Protein
A	mpstruc	TRANSMEMBRANE PROTEINS: ALPHA-HELICAL	Sterol-Sensing Domain (SSD) Proteins	Niemann-Pick C1-Like 1 (NPC1L1) cholesterol intracellular transporter protein

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.