6UTJ

Allosteric couple between alpha rings of the 20S proteasome. 20S proteasome singly capped by PA26/E102A, C-terminus replaced by PAN C-terminus

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
G	d6utjg_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
B	d6utjb_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
F	d6utjf_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
H [auth O]	d6utjo1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
H [auth O]	d6utjo2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
K [auth R]	d6utjr1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
K [auth R]	d6utjr2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
M [auth T]	d6utjt1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
M [auth T]	d6utjt2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
I [auth P]	d6utjp1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
I [auth P]	d6utjp2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
J [auth Q]	d6utjq1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
J [auth Q]	d6utjq2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
L [auth S]	d6utjs1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
L [auth S]	d6utjs2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
N [auth U]	d6utju1	All alpha proteins	Four-helical up-and-down bundle	Proteasome activator	Proteasome activator	automated matches	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
N [auth U]	d6utju2	Artifacts	Tags	Tags	Tags	C-terminal Tags	(Trypanosoma brucei ) [TaxId: 5691 ],	SCOPe (2.08)
O [auth Z]	d6utjz_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
R [auth N]	d6utjn_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
V [auth I]	d6utji_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
X [auth J]	d6utjj_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
Y [auth X]	d6utjx_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
Z [auth K]	d6utjk_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
AA [auth Y]	d6utjy_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
BA [auth L]	d6utjl_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
P [auth M]	d6utjm_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
Q [auth 1]	d6utj1_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
S [auth 2]	d6utj2_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
T [auth H]	d6utjh_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
U [auth V]	d6utjv_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
W	d6utjw_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome beta subunit (catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
FA [auth d]	d6utjd_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
CA [auth a]	d6utja_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
EA [auth c]	d6utjc_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)
GA [auth e]	d6utje_	Alpha and beta proteins (a+b)	Ntn hydrolase-like	N-terminal nucleophile aminohydrolases (Ntn hydrolases)	Proteasome subunits	Proteasome alpha subunit (non-catalytic)	(Thermoplasma acidophilum ) [TaxId: 2303 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
D	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
O [auth Z]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
R [auth N]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
V [auth I]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
X [auth J]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
Y [auth X]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
Z [auth K]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
AA [auth Y]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
BA [auth L]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
P [auth M]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
Q [auth 1]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
S [auth 2]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
T [auth H]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
U [auth V]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Class II glutamine amidotransferases	8034254	3000131	SCOP2B (2022-06-29)
FA [auth d]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
HA [auth f]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
IA [auth g]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
CA [auth a]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
DA [auth b]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
EA [auth c]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)
GA [auth e]	SCOP2B Superfamily	Class II glutamine amidotransferases	8034248	3000131	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
D	PF00227,PF10584	e6utjD1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
G	PF00227,PF10584	e6utjG1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
A	PF00227,PF10584	e6utjA1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
B	PF00227,PF10584	e6utjB1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
C	PF00227,PF10584	e6utjC1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
E	PF00227,PF10584	e6utjE1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
F	PF00227,PF10584	e6utjF1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
H [auth O]	PF02252	e6utjO1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
K [auth R]	PF02252	e6utjR1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
M [auth T]	PF02252	e6utjT1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
I [auth P]	PF02252	e6utjP1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
J [auth Q]	PF02252	e6utjQ1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
L [auth S]	PF02252	e6utjS1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
N [auth U]	PF02252	e6utjU1	A: alpha bundles	X: Four-helical up-and-down bundle	H: Proteasome activator reg(alpha) (From Topology)	T: Proteasome activator reg(alpha)	F: PF02252	ECOD (1.6)
O [auth Z]	PF00227	e6utjZ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
R [auth N]	PF00227	e6utjN1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
V [auth I]	PF00227	e6utjI1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
X [auth J]	PF00227	e6utjJ1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Y [auth X]	PF00227	e6utjX1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Z [auth K]	PF00227	e6utjK1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
AA [auth Y]	PF00227	e6utjY1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
BA [auth L]	PF00227	e6utjL1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
P [auth M]	PF00227	e6utjM1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
Q [auth 1]	PF00227	e6utj11	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
S [auth 2]	PF00227	e6utj21	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
T [auth H]	PF00227	e6utjH1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
U [auth V]	PF00227	e6utjV1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
W	PF00227	e6utjW1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227	ECOD (1.6)
FA [auth d]	PF00227,PF10584	e6utjd1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
HA [auth f]	PF00227,PF10584	e6utjf1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
IA [auth g]	PF00227,PF10584	e6utjg1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
CA [auth a]	PF00227,PF10584	e6utja1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
DA [auth b]	PF00227,PF10584	e6utjb1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
EA [auth c]	PF00227,PF10584	e6utjc1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)
GA [auth e]	PF00227,PF10584	e6utje1	A: a+b four layers	X: Ntn/PP2C	H: Ntn	T: Proteasome subunits	F: PF00227,PF10584	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
A, B, C, D, E A, B, C, D, E, F, G	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family
H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], M [auth T], N [auth U]	PF02252	Proteasome activator pa28 beta subunit (PA28_beta)	Proteasome activator pa28 beta subunit	-	Family
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	PF00227	Proteasome subunit (Proteasome)	Proteasome subunit	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity ...	The proteasome is a multisubunit structure that degrades proteins. Protein degradation is an essential component of regulation because proteins can become misfolded, damaged, or unnecessary. Proteasomes and their homologues vary greatly in complexity: from HslV (heat shock locus v), which is encoded by 1 gene in bacteria, to the eukaryotic 20S proteasome, which is encoded by more than 14 genes [1]. Recently evidence of two novel groups of bacterial proteasomes was proposed. The first is Anbu, which is sparsely distributed among cyanobacteria and proteobacteria [1]. The second is call beta-proteobacteria proteasome homologue (BPH) [1].	Domain
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	PF10584	Proteasome subunit A N-terminal signature (Proteasome_A_N)	Proteasome subunit A N-terminal signature	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G	Proteasome subunit alpha	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex
H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], M [auth T], N [auth U]	Proteasome activator protein PA26	-	catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation catabolic process proteolysis involved in protein catabolic process macromolecule catabolic process regulation of primary metabolic process organic substance metabolic process regulation of proteolysis involved in protein catabolic process regulation of proteolysis proteolysis protein metabolic process organonitrogen compound catabolic process regulation of biological process organonitrogen compound metabolic process regulation of protein metabolic process biological regulation primary metabolic process proteasomal protein catabolic process regulation of macromolecule metabolic process protein catabolic process regulation of catabolic process regulation of proteasomal protein catabolic process metabolic process macromolecule metabolic process regulation of metabolic process organic substance catabolic process regulation of protein catabolic process	proteasome accessory complex protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome activator complex proteasome complex endopeptidase complex cellular anatomical entity intracellular protein-containing complex
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	Proteasome subunit beta	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process proteasomal protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process proteolysis metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process	protein-containing complex intracellular anatomical structure catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex cellular anatomical entity intracellular protein-containing complex proteasome core complex, beta-subunit complex cytoplasm
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	Proteasome subunit alpha	peptidase activity catalytic activity, acting on a protein threonine-type peptidase activity hydrolase activity catalytic activity endopeptidase activity threonine-type endopeptidase activity	organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process organonitrogen compound catabolic process organonitrogen compound metabolic process catabolic process proteolysis involved in protein catabolic process primary metabolic process protein catabolic process macromolecule catabolic process organic substance metabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process metabolic process protein metabolic process macromolecule metabolic process organic substance catabolic process proteasomal protein catabolic process	intracellular anatomical structure cytoplasm cellular anatomical entity protein-containing complex proteasome core complex, alpha-subunit complex catalytic complex peptidase complex proteasome complex endopeptidase complex proteasome core complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
A, B, C, D, E A, B, C, D, E, F, G	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G	IPR023332	Proteasome alpha-type subunit	Family
A, B, C, D, E A, B, C, D, E, F, G	IPR001353	Proteasome, subunit alpha/beta	Family
A, B, C, D, E A, B, C, D, E, F, G	IPR019982	Proteasome alpha subunit, archaeal	Family
H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], M [auth T], N [auth U]	IPR003186	Proteasome activator PA28, C-terminal domain	Domain
H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], M [auth T], N [auth U]	IPR036252	Proteasome activator superfamily	Homologous Superfamily
H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], H [auth O], I [auth P], J [auth Q], K [auth R], L [auth S], M [auth T], N [auth U]	IPR036997	Proteasome activator PA28, C-terminal domain superfamily	Homologous Superfamily
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR016050	Proteasome beta-type subunit, conserved site	Conserved Site
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR023333	Proteasome B-type subunit	Family
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR019983	Peptidase T1A, proteasome beta-subunit, archaeal	Family
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR001353	Proteasome, subunit alpha/beta	Family
AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], AA [auth Y], BA [auth L], O [auth Z], P [auth M], Q [auth 1], R [auth N], S [auth 2], T [auth H], U [auth V], V [auth I], W, X [auth J], Y [auth X], Z [auth K]	IPR000243	Peptidase T1A, proteasome beta-subunit	Family
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	IPR000426	Proteasome alpha-subunit, N-terminal domain	Domain
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	IPR029055	Nucleophile aminohydrolases, N-terminal	Homologous Superfamily
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	IPR023332	Proteasome alpha-type subunit	Family
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	IPR001353	Proteasome, subunit alpha/beta	Family
CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], CA [auth a], DA [auth b], EA [auth c], FA [auth d], GA [auth e], HA [auth f], IA [auth g]	IPR019982	Proteasome alpha subunit, archaeal	Family