6URT

Extended Sensor Paddles with Bound Lipids Revealed in Mechanosensitive Channel YnaI

External Resource: Annotation

Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Membrane Protein Annotation: OPM
Membrane Protein Annotation: PDBTM
Membrane Protein Annotation: MemProtMD

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	PF00924	Mechanosensitive ion channel, beta-domain (MS_channel_2nd)	Mechanosensitive ion channel, beta-domain	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antipara ...	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain [4-7]. This is the beta domain which adopts a SH3-like barrel structure.	Domain
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	PF21088	Mechanosensitive ion channel, transmembrane helices 2/3 (MS_channel_1st)	Mechanosensitive ion channel, transmembrane helices 2/3	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antipara ...	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain [4-7]. The N-terminal region consists of three membrane spanning helices (TM1, TM2 and TM3), TM2 and TM3 are represented in this entry. In the heptamer, the permeation pathway is formed by the packing of TM3s, flanked by TM1-TM2 helical hairpins [4].	Domain
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	PF21082	Mechanosensitive ion channel MscS, C-terminal (MS_channel_3rd)	Mechanosensitive ion channel MscS, C-terminal	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antipara ...	This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [1-6]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet domain (beta-domain, Pfam:PF00924) and a C-terminal alpha/beta-domain [1,2,3]. This is the C-terminal domain of McsS which, together with the middle beta-domain, creates a framework that connects to the cytoplasm through distinct openings [4-6].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	Low conductance mechanosensitive channel YnaI	identical protein binding protein binding binding passive transmembrane transporter activity gated channel activity monoatomic ion channel activity channel activity monoatomic ion transmembrane transporter activity transporter activity transmembrane transporter activity mechanosensitive monoatomic ion channel activity	cellular response to stimulus response to osmotic stress response to stimulus cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to chemical stimulus cellular response to stress response to stress response to chemical cellular process response to abiotic stimulus cellular response to abiotic stimulus	cell periphery plasma membrane membrane cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR006685	Mechanosensitive ion channel MscS	Domain
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR011014	Mechanosensitive ion channel MscS, transmembrane-2	Homologous Superfamily
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR011066	Mechanosensitive ion channel MscS, C-terminal domain superfamily	Homologous Superfamily
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR045042	Mechanosensitive ion channel protein YnaI-like	Family
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR023408	Mechanosensitive ion channel MscS, beta-domain superfamily	Homologous Superfamily
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR049142	Mechanosensitive ion channel, transmembrane helices 2/3	Domain
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR010920	LSM domain superfamily	Homologous Superfamily
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR006686	Mechanosensitive ion channel MscS, conserved site	Conserved Site
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	IPR049278	Mechanosensitive ion channel MscS, C-terminal domain	Domain

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D] A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	OPM	Transmembrane	Alpha-helical polytopic	Small conductance mechanosensitive ion channel (MscS)	Small conductance mechanosensitive ion channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D] A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	PDBTM	Annotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

Chains	External Link	Comment
A [auth G], B [auth A], C [auth B], D [auth C], E [auth D] A [auth G], B [auth A], C [auth B], D [auth C], E [auth D], F [auth E], G [auth F]	MemProtMD	Annotated as membrane protein by MemProtMD

RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.