6UMG

Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
IMGT Antibody Annotation
SAbDab Antibody Annotation
Thera-SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth H]	d6umgh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth L]	d6umgl2	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	C1 set domains (antibody constant domain-like)	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B [auth L]	d6umgl1	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	automated matches	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C	SCOP2B Superfamily	FnI-like domain	8091130	3000979	SCOP2B (2022-06-29)
G [auth c]	SCOP2B Superfamily	FnI-like domain	8091130	3000979	SCOP2B (2022-06-29)
D [auth R]	SCOP2B Superfamily	RAMP1-like	8054000	3002261	SCOP2B (2022-06-29)
H [auth r]	SCOP2B Superfamily	RAMP1-like	8054000	3002261	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
E [auth h]	PF07654	e6umgh1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
E [auth h]	PF07686	e6umgh2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
A [auth H]	PF07654	e6umgH2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
A [auth H]	PF07686	e6umgH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
B [auth L]	PF07654	e6umgL2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
B [auth L]	PF07686	e6umgL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
F [auth l]	PF07654	e6umgl1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07654	ECOD (1.6)
F [auth l]	PF07686	e6umgl2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: PF07686	ECOD (1.6)
C	PF02793	e6umgC1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: PF02793	ECOD (1.6)
G [auth c]	PF02793	e6umgc1	A: few secondary structure elements	X: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	H: Hormone receptor domain (HRM, Pfam 02793) (From Topology)	T: Hormone receptor domain (HRM, Pfam 02793)	F: PF02793	ECOD (1.6)
D [auth R]	PF04901	e6umgR1	A: alpha bundles	X: Receptor activity-modifying protein (RAMP) (From Topology)	H: Receptor activity-modifying protein (RAMP) (From Topology)	T: Receptor activity-modifying protein (RAMP)	F: PF04901	ECOD (1.6)
H [auth r]	PF04901	e6umgr1	A: alpha bundles	X: Receptor activity-modifying protein (RAMP) (From Topology)	H: Receptor activity-modifying protein (RAMP) (From Topology)	T: Receptor activity-modifying protein (RAMP)	F: PF04901	ECOD (1.6)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
A [auth H], E [auth h]	mAb Erenumab, anti-GPCR	VH-CH1	Homo sapiens (human)	IGHV3-3003, IGHV3-3006, IGHV3-3012, IGHV3-3019, IGHV3-3305, IGHJ301, IGHG101, IGHG102, IGHG104, IGHG105, IGHG112, IGHG114, IGHG113, IGHG109, IGHG110, IGHG107, IGHG1*11	V-DOMAIN VH, C-DOMAIN CH1	IG	FAB-GAMMA-1_LAMBDA	IMGT (202419-0)
B [auth L], F [auth l]	mAb Erenumab, anti-GPCR	L-LAMBDA	Homo sapiens (human)	IGLV1-5101, IGLJ201, IGLJ301, IGLC102	V-DOMAIN V-LAMBDA, C-DOMAIN C-LAMBDA	IG	FAB-GAMMA-1_LAMBDA	IMGT (202419-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], E [auth h]	Heavy Chain	IGHV3	-	calcitonin gene-related peptide type 1 receptor \| receptor activity-modifying protein 1, unknown \| unknown	SAbDab (2024-05-17)
B [auth L], F [auth l]	Light Chain	IGLV1	Lambda	calcitonin gene-related peptide type 1 receptor \| receptor activity-modifying protein 1, unknown \| unknown	SAbDab (2024-05-17)

Thera-SAbDab Antibody Annotation Thera-SAbDab Database Homepage

Chain	Name	Target	Provenance Source
A [auth H], E [auth h]	Erenumab	CALCRL	Therapeutic SAbDab (2024-05-17)
B [auth L], F [auth l]	Erenumab	CALCRL	Therapeutic SAbDab (2024-05-17)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, G [auth c]	PF02793	Hormone receptor domain (HRM)	Hormone receptor domain	-	Family
D [auth R], H [auth r]	PF04901	Receptor activity modifying family (RAMP)	Receptor activity modifying family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], E [auth h]	erenumab Fab heavy chain, IgG1	-	-	-
B [auth L], F [auth l]	erenumab Fab light chain, IgG1	-	-	-
C, G [auth c]	Calcitonin gene-related peptide type 1 receptor	calcitonin family receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity calcitonin receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding calcitonin family receptor activity peptide receptor activity molecular transducer activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity signaling receptor activity calcitonin receptor activity calcitonin family binding amide binding binding adrenomedullin binding peptide hormone binding hormone binding adrenomedullin receptor activity calcitonin gene-related peptide receptor activity	developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis developmental process heart development multicellular organism development multicellular organismal process anatomical structure development animal organ development circulatory system development system development localization import into cell receptor internalization transport cellular process receptor-mediated endocytosis endocytosis establishment of localization vesicle-mediated transport blood vessel morphogenesis tube development angiogenesis vasculature development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development protein localization establishment of protein localization cellular localization nitrogen compound transport organic substance transport protein transport cellular macromolecule localization macromolecule localization regulation of vascular associated smooth muscle cell proliferation regulation of biological process cell population proliferation regulation of cellular process positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation biological regulation positive regulation of biological process smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation positive regulation of cellular process cellular response to stimulus response to stimulus signaling adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway signal transduction cell surface receptor signaling pathway adrenomedullin receptor signaling pathway calcitonin family receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway response to organic substance response to disaccharide response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to sucrose stimulus cellular response to carbohydrate stimulus cellular response to chemical stimulus response to carbohydrate response to sucrose response to chemical cellular response to disaccharide stimulus cellular response to organic substance monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex adrenomedullin receptor complex plasma membrane signaling receptor complex G protein-coupled receptor complex cell periphery plasma membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm protein-containing complex plasma membrane protein complex membrane protein complex receptor complex G protein-coupled receptor dimeric complex adrenomedullin receptor complex plasma membrane signaling receptor complex G protein-coupled receptor complex calcitonin family receptor complex membrane-bounded organelle intracellular organelle organelle lytic vacuole vacuole intracellular membrane-bounded organelle lysosome endosome intracellular vesicle endomembrane system cytoplasmic vesicle vesicle CGRP receptor complex endoplasmic reticulum
D [auth R], H [auth r]	Receptor activity-modifying protein 1	calcitonin family binding calcitonin gene-related peptide binding amide binding binding peptide hormone binding hormone binding molecular transducer activity coreceptor activity signaling receptor activity calcitonin family receptor activity peptide receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity calcitonin family binding calcitonin gene-related peptide binding amide binding binding peptide hormone binding hormone binding molecular transducer activity coreceptor activity signaling receptor activity calcitonin family receptor activity peptide receptor activity G protein-coupled receptor activity G protein-coupled peptide receptor activity transmembrane signaling receptor activity calcitonin gene-related peptide receptor activity amylin receptor activity	cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction protein localization cellular localization cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation adenylate cyclase-activating G protein-coupled receptor signaling pathway cell communication adenylate cyclase-modulating G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway cellular process signal transduction protein localization cellular localization establishment of protein localization nitrogen compound transport transport organic substance transport intracellular transport establishment of localization localization protein transport establishment of localization in cell cellular macromolecule localization macromolecule localization intracellular protein transport regulation of signaling regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of G protein-coupled receptor signaling pathway import into cell receptor internalization receptor-mediated endocytosis endocytosis vesicle-mediated transport developmental process multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure development anatomical structure formation involved in morphogenesis blood vessel development system development calcitonin family receptor signaling pathway calcitonin gene-related peptide receptor signaling pathway positive regulation of glycoprotein metabolic process organonitrogen compound biosynthetic process carbohydrate derivative metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process positive regulation of metabolic process organic substance biosynthetic process positive regulation of macromolecule metabolic process protein modification process regulation of protein metabolic process cellular metabolic process glycoprotein biosynthetic process primary metabolic process regulation of cellular metabolic process glycoprotein metabolic process regulation of glycoprotein metabolic process biosynthetic process macromolecule modification regulation of protein glycosylation metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process positive regulation of protein metabolic process cellular biosynthetic process positive regulation of biological process positive regulation of cellular metabolic process positive regulation of protein glycosylation positive regulation of protein modification process organic substance metabolic process positive regulation of biosynthetic process protein metabolic process regulation of glycoprotein biosynthetic process positive regulation of cellular process positive regulation of glycoprotein biosynthetic process carbohydrate derivative biosynthetic process regulation of biosynthetic process organonitrogen compound metabolic process regulation of macromolecule metabolic process macromolecule biosynthetic process protein glycosylation regulation of cellular biosynthetic process glycosylation macromolecule glycosylation positive regulation of cellular biosynthetic process amylin receptor signaling pathway monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport protein localization to cell periphery protein localization to plasma membrane localization within membrane protein localization to membrane response to organic substance response to endogenous stimulus cellular response to endogenous stimulus cellular response to chemical stimulus response to hormone response to chemical cellular response to organic substance cellular response to hormone stimulus	protein-containing complex receptor complex cell surface cellular anatomical entity cell periphery plasma membrane membrane plasma membrane protein complex membrane protein complex plasma membrane signaling receptor complex G protein-coupled receptor complex CGRP receptor complex calcitonin family receptor complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, G [auth c]	IPR017983	GPCR, family 2, secretin-like, conserved site	Conserved Site
C, G [auth c]	IPR036445	GPCR family 2, extracellular hormone receptor domain superfamily	Homologous Superfamily
C, G [auth c]	IPR000832	GPCR, family 2, secretin-like	Family
C, G [auth c]	IPR017981	GPCR, family 2-like, 7TM	Domain
C, G [auth c]	IPR001879	GPCR, family 2, extracellular hormone receptor domain	Domain
C, G [auth c]	IPR003287	GPCR, family 2, calcitonin receptor family	Family
C, G [auth c]	IPR003289	GPCR, family 2, calcitonin gene-related peptide, type 1 receptor	Family
D [auth R], H [auth r]	IPR038126	RAMP domain superfamily	Homologous Superfamily
D [auth R], H [auth r]	IPR006985	Receptor activity modifying protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, G [auth c]	Pharos: Q16602	allergic contact dermatitis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Preventive treatment of episodic migraine in adults tuberculosis glioblastoma large cell medulloblastoma lung carcinoma medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma primitive neuroectodermal tumor ulcerative colitis astrocytic tumor heart disease allergic contact dermatitis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Preventive treatment of episodic migraine in adults tuberculosis glioblastoma large cell medulloblastoma lung carcinoma medulloblastoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma primitive neuroectodermal tumor ulcerative colitis astrocytic tumor heart disease lung adenocarcinoma malignant ependymoma migraine disorder osteosarcoma pancreatic intraductal papillary-mucinous neoplasm psoriasis atypical teratoid rhabdoid tumor interstitial cystitis lung cancer malignant glioma non-small cell lung carcinoma ovarian cancer
D [auth R], H [auth r]	Pharos: O60894	Liver Cirrhosis, Experimental migraine disorder atypical teratoid rhabdoid tumor large cell medulloblastoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor ulcerative colitis breast carcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia interstitial cystitis lung adenocarcinoma Liver Cirrhosis, Experimental migraine disorder atypical teratoid rhabdoid tumor large cell medulloblastoma malignant mesothelioma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor ulcerative colitis breast carcinoma medulloblastoma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia interstitial cystitis lung adenocarcinoma pancreatic intraductal papillary-mucinous carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198.